The Upstream Enhancer Is Necessary and Sufficient for the Expression of the Pre-T Cell Receptor α Gene in Immature T Lymphocytes

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

2000 • 2,528 citations

BLAST 2 Sequences, a new tool for comparing protein and nucleotide sequences

1999 • 1,813 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis

1991 • 1,074 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

1993 • 858 citations

Transcription factor GATA-3 is required for development of the T-cell lineage

1996 • 614 citations

Rapid modification of bacterial artificial chromosomes by ET- recombination

1999 • 533 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

E2A Deficiency Leads to Abnormalities in αβ T-Cell Development and to Rapid Development of T-Cell Lymphomas

1997 • 400 citations

Notch Activity Influences the αβ versus γδ T Cell Lineage Decision

1997 • 399 citations

Notch1 Signaling Promotes the Maturation of CD4 and CD8 SP Thymocytes

2000 • 317 citations

TRANSCRIPTIONAL REGULATION OF T LYMPHOCYTE DEVELOPMENT AND FUNCTION

1999 • 293 citations

Inhibition of T Cell and Promotion of Natural Killer Cell Development by the Dominant Negative Helix Loop Helix Factor Id3

1997 • 279 citations

Early αβ T cell development in the thymus of normal and genetically altered mice

1997 • 249 citations

Extension of chromatin accessibility by nuclear matrix attachment regions

1997 • 237 citations

SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-Tα chain expression

2000 • 210 citations

The bHLH gene Hes1 is essential for expansion of early T cell precursors

1999 • 208 citations

Pleiotropic changes controlled by the pre-T-cell receptor

1999 • 199 citations

A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines.

1993 • 173 citations

Position-dependent variegation of globin transgene expression in mice.

1995 • 159 citations

Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors.

1994 • 154 citations

c-Myb is essential for early T cell development

1999 • 153 citations

Recognition of specific DNA sequences by the c-myb protooncogene product: role of three repeat units in the DNA-binding domain.

1993 • 150 citations

Coordinate Regulation of RAG1 and RAG2 by Cell Type-Specific DNA Elements 5' of RAG2

1999 • 145 citations

A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis.

1999 • 133 citations

Expression of the CD4 gene requires a Myb transcription factor.

1992 • 127 citations

Functional dissection of the lck proximal promoter.

1992 • 120 citations

Intra‐ and extra‐thymic expression of the pre‐T cell receptor α gene

1995 • 109 citations

Functional analysis of the human adenosine deaminase gene thymic regulatory region and its ability to generate position-independent transgene expression.

1992 • 108 citations

Multiple Developmental Stage–Specific Enhancers Regulate CD8 Expression in Developing Thymocytes and in Thymus-Independent T Cells

1998 • 107 citations

A Novel Role for HEB Downstream or Parallel to the Pre-TCR Signaling Pathway During αβ Thymopoiesis

1999 • 101 citations

The role of E-proteins in B- and T-lymphocyte development

1998 • 97 citations

Disruption of αβ but not of γδ T cell development by overexpression of the helix–loop–helix protein Id3 in committed T cell progenitors

1999 • 96 citations

Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lck proximal promoter activity

2001 • 88 citations

A T cell-specific enhancer is located in a DNase I-hypersensitive area at the 3′ end of the CD3-delta gene.

1988 • 81 citations

Stepwise specification of lymphocyte developmental lineages

2000 • 81 citations

A Heterodimer of HEB and an E12-Related Protein Interacts with the CD4 Enhancer and Regulates Its Activity in T-Cell Lines

1993 • 71 citations

Expression of functional interleukin-2 receptors in human light chain/Tac ransgenic mice

1988 • 70 citations

c-Myb Binds to a Sequence in the Proximal Region of the RAG-2 Promoter and Is Essential for Promoter Activity in T-Lineage Cells

2000 • 63 citations

Negative Regulation of CD4 Gene Expression by a HES-1–c-Myb Complex

2001 • 59 citations

Diverse developing mouse lineages exhibit high-level c-Myb expression in immature cells and loss of expression upon differentiation

1999 • 58 citations

A Transgenic Marker for Mouse B Lymphoid Precursors

1997 • 58 citations

c-Myb regulates the proliferation of immature thymocytes following beta-selection

2000 • 53 citations

Expression of the Mouse Pre-T Cell Receptor α Gene Is Controlled by an Upstream Region Containing a Transcriptional Enhancer

1999 • 53 citations

Functional Dissection of the lck Proximal Promoter

1992 • 51 citations

Recognition of specific DNA sequence by the c-myb proto-oncogene product : Role of three repeat units in the DNA-binding domain

1993 • 50 citations

Expression of the CD4 Gene Requires a Myb Transcription Factor

1992 • 50 citations

Regulation of the T-cell receptor δ enhancer by functional cooperation between c-Myb and core-binding factors

1994 • 48 citations

Co-ordination of the expression of the protein tyrosine kinase p56lck with the pre-T cell receptor during thymocyte development

2000 • 47 citations

The role of c-Myb or a related factor in regulating the T cell receptor gamma gene enhancer.

1995 • 43 citations

A Central Role for a Single c-Myb Binding Site in a Thymic Locus Control Region

1995 • 40 citations

Functional Analysis of the Human Adenosine Deaminase Gene Thymic Regulatory Region and Its Ability To Generate Position-Independent Transgene Expression

1992 • 38 citations

Myb and Ets related transcription factors are required for activity of the human lck type I promoter.

1994 • 37 citations

To be or not to be a pro-T?

2000 • 30 citations

Homologous Genomic Fragments in the Mouse Pre-T Cell Receptor α (pTa) and Xist Loci

2000 • 8 citations