A Transgenic Marker for Mouse B Lymphoid Precursors

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1985 • 1,292 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

1984 • 858 citations

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

1994 • 766 citations

Expression and function of c-kit in hemopoietic progenitor cells.

1991 • 756 citations

The helix-loop-helix gene E2A is required for B cell formation

1994 • 679 citations

Failure of B-cell differentiation in mice lacking the transcription factor EBF

1995 • 667 citations

The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver.

1993 • 573 citations

Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.

1983 • 457 citations

Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement

1995 • 363 citations

Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo.

1991 • 335 citations

A second gene, VpreB in the lambda 5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes.

1987 • 306 citations

λ5, a new light-chain-related locus selectively expressed in pre-B lymphocytes

1986 • 302 citations

B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac.

1988 • 292 citations

IL-2 receptor α chain (CD25JAC) expression defines a crucial stage in pre-B cell development

1994 • 284 citations

The surrogate light chain in B-cell development

1993 • 282 citations

A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors.

1996 • 236 citations

Analysis of the B-cell progenitor compartment at the level of single cells

1994 • 232 citations

The status of Ig loci rearrangements in single cells from different stages of B cell development

1995 • 186 citations

T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.

1989 • 182 citations

A complex of glycoproteins is associated with VpreB/lambda 5 surrogate light chain on the surface of mu heavy chain-negative early precursor B cell lines.

1993 • 141 citations

Changes in frequencies of clonable pre B cells during life in different lymphoid organs of mice

1993 • 138 citations

Functional dissection of the lck proximal promoter.

1992 • 120 citations

Precursor B cells of mouse bone marrow express two different complexes with the surrogate light chain on the surface

1995 • 116 citations

Interferon‐γ arrests proliferation and causes apoptosis in stromal cell/interleukin‐7‐dependent normal murine pre‐B cell lines and clones in vitro, but does not induce differentiation to surface immunoglobulin‐positive B cells

1993 • 86 citations

Expression of functional interleukin-2 receptors in human light chain/Tac ransgenic mice

1988 • 70 citations

Rearrangement of a chicken immunoglobulin gene occurs in the lymphoid lineage of transgenic mice

1987 • 64 citations

Random activation of a transgene under the control of a hybrid hCD2 locus control region/Ig enhancer regulatory element.

1995 • 52 citations

Functional Dissection of the lck Proximal Promoter

1992 • 51 citations

Identification and localization of a developmental stage-specific promoter activity from the murine lambda 5 gene.

1995 • 32 citations

Pre-B cell-specific λ5 gene expression due to suppression in non pre-B cells

1994 • 28 citations

Tissue-specific expression of the rat insulin 1 gene in vivo requires both the enhancer and promoter regions

1995 • 17 citations

Relative expression of surface IgM, IgD and the Ig-associating alpha(mb-1) and beta(B-29) polypeptide chains.

1992 • 12 citations