Functional dissection of the lck proximal promoter.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination

1977 • 3,548 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

A Method for Isolation of Intact, Translationally Active Ribonucleic Acid

1983 • 1,469 citations

GPI-Anchored Cell-Surface Molecules Complexed to Protein Tyrosine Kinases

1991 • 848 citations

[21] β-Galactosidase gene fusions for analyzing gene expression in Escherichia coli and yeast

1983 • 783 citations

Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses.

1988 • 736 citations

Introns increase transcriptional efficiency in transgenic mice.

1988 • 733 citations

Human CCAAT-binding proteins have heterologous subunits

1988 • 712 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]

1991 • 627 citations

Interaction of the IL-2 Receptor with thesrc-Family Kinase p56^lck: Identification of Novel Intermolecular Association

1991 • 576 citations

Multiple specific contacts between a mammalian transcription factor and its cognate promoters

1984 • 565 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box.

1991 • 545 citations

Heterologous introns can enhance expression of transgenes in mice.

1991 • 489 citations

Globin gene regulation and switching: Circa 1990

1990 • 463 citations

The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

1989 • 447 citations

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)

1991 • 395 citations

Human CD2 3′-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice

1989 • 385 citations

A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer.

1991 • 372 citations

A generic intron increases gene expression in transgenic mice.

1991 • 351 citations

CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus

1991 • 343 citations

Regulation, linkage, and sequence of mouse metallothionein I and II genes.

1984 • 335 citations

Identification of a myocyte nuclear factor that binds to the muscle-specific enhancer of the mouse muscle creatine kinase gene.

1989 • 326 citations

Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.

1990 • 235 citations

Target Detection Assay (TDA): a versatile procedure to determine DNA blinding sites as demonstrated on SP1 protein

1990 • 229 citations

Spermatid-specific expression of protamine 1 in transgenic mice.

1987 • 223 citations

LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocyte-specific genes.

1991 • 203 citations

Transcription of T cell receptor beta-chain genes is controlled by a downstream regulatory element.

1988 • 185 citations

Thymic tumorigenesis induced by overexpression of p56lck.

1991 • 172 citations

A T-cell-specific transcriptional enhancer element 3' of C alpha in the human T-cell receptor alpha locus.

1989 • 165 citations

Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers.

1991 • 146 citations

Regulation of pp56lck during T-cell activation: functional implications for the src-like protein tyrosine kinases.

1987 • 139 citations

A dictionary of transcription control sequences

1990 • 124 citations

Developmental regulation of lck gene expression in T lymphocytes.

1991 • 124 citations

Delayed thymocyte development induced by augmented expression of p56lck.

1991 • 117 citations

Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene.

1991 • 116 citations

A Generic Intron Increases Gene Expression in Transgenic Mice

1991 • 114 citations

The rat elastase I regulatory element is an enhancer that directs correct cell specificity and developmental onset of expression in transgenic mice.

1987 • 109 citations

Identification of a Myocyte Nuclear Factor That Binds to the Muscle-Specific Enhancer of the Mouse Muscle Creatine Kinase Gene

1989 • 101 citations

Regulation, Linkage, and Sequence of Mouse Metallothionein I and II Genes

1984 • 96 citations

Disruption of thymocyte development and lymphomagenesis induced by SV4O T-antigen

1990 • 91 citations

Purification of TCF-1 alpha, a T-cell-specific transcription factor that activates the T-cell receptor C alpha gene enhancer in a context-dependent manner.

1990 • 88 citations

Structure of the Murine lck Gene and Its Rearrangement in a Murine Lymphoma Cell Line

1988 • 86 citations

A T cell-specific enhancer is located in a DNase I-hypersensitive area at the 3′ end of the CD3-delta gene.

1988 • 81 citations

The functional domains of the murine Thy-1 gene promoter.

1991 • 77 citations

Changes in the relative abundance of type I and type II lck mRNA transcripts suggest differential promoter usage during T-cell development.

1990 • 62 citations

LyF-1, a Transcriptional Regulator That Interacts with a Novel Class of Promoters for Lymphocyte-Specific Genes

1991 • 61 citations

Structure of the two promoters of the human lck gene: differential accumulation of two classes of lck transcripts in T cells.

1989 • 61 citations

An enhancer located in a CpG-island 3′ to the TCR/CD3-epsilon gene confers T lymphocyte-specificity to its promoter.

1989 • 59 citations

Regulation of the human T-cell receptor alpha gene enhancer: multiple ubiquitous and T-cell-specific nuclear proteins interact with four hypomethylated enhancer elements.

1990 • 52 citations

Identification and Characterization of a T-Cell-Specific Enhancer Adjacent to the Murine CD4 Gene

1991 • 43 citations

Identification of a T-cell-specific enhancer at the locus encoding T-cell antigen receptor gamma chain.

1991 • 42 citations

The Rat Elastase I Regulatory Element is an Enhancer that Directs Correct Cell Specificity and Developmental Onset of Expression in Transgenic Mice

1987 • 37 citations

Selective expression of alternative lck mRNAs in human malignant cell lines.

1989 • 34 citations

Translocation of an erythroid-specific hypersensitive site in deletion-type hereditary persistence of fetal hemoglobin.

1990 • 32 citations

T Cell Signaling

1989 • 30 citations

Regulation of the Human T-Cell Receptor α Gene Enhancer: Multiple Ubiquitous and T-Cell-Specific Nuclear Proteins Interact with Four Hypomethylated Enhancer Elements

1990 • 22 citations

The Functional Domains of the Murine Thy-1 Gene Promoter

1991 • 16 citations

Translocation of an Erythroid-Specific Hypersensitive Site in Deletion-Type Hereditary Persistence of Fetal Hemoglobin

1990 • 9 citations