Functional Dissection of the lck Proximal Promoter

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination

1977 • 3,548 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

A Method for Isolation of Intact, Translationally Active Ribonucleic Acid

1983 • 1,469 citations

GPI-Anchored Cell-Surface Molecules Complexed to Protein Tyrosine Kinases

1991 • 848 citations

[21] β-Galactosidase gene fusions for analyzing gene expression in Escherichia coli and yeast

1983 • 783 citations

Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses.

1988 • 736 citations

Introns increase transcriptional efficiency in transgenic mice.

1988 • 733 citations

Human CCAAT-binding proteins have heterologous subunits

1988 • 712 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]

1991 • 627 citations

Interaction of the IL-2 Receptor with thesrc-Family Kinase p56^lck: Identification of Novel Intermolecular Association

1991 • 576 citations

Multiple specific contacts between a mammalian transcription factor and its cognate promoters

1984 • 565 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box.

1991 • 545 citations

Heterologous introns can enhance expression of transgenes in mice.

1991 • 489 citations

Globin gene regulation and switching: Circa 1990

1990 • 463 citations

The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

1989 • 447 citations

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)

1991 • 395 citations

Human CD2 3′-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice

1989 • 385 citations

A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer.

1991 • 372 citations

CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus

1991 • 343 citations

Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.

1990 • 235 citations

Target Detection Assay (TDA): a versatile procedure to determine DNA blinding sites as demonstrated on SP1 protein

1990 • 229 citations

Spermatid-specific expression of protamine 1 in transgenic mice.

1987 • 223 citations

Transcription of T cell receptor beta-chain genes is controlled by a downstream regulatory element.

1988 • 185 citations

Thymic tumorigenesis induced by overexpression of p56lck.

1991 • 172 citations

A T-cell-specific transcriptional enhancer element 3' of C alpha in the human T-cell receptor alpha locus.

1989 • 165 citations

Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers.

1991 • 146 citations

Regulation of pp56lck during T-cell activation: functional implications for the src-like protein tyrosine kinases.

1987 • 139 citations

Developmental regulation of lck gene expression in T lymphocytes.

1991 • 124 citations

A dictionary of transcription control sequences

1990 • 124 citations

Delayed thymocyte development induced by augmented expression of p56lck.

1991 • 117 citations

Disruption of thymocyte development and lymphomagenesis induced by SV4O T-antigen

1990 • 91 citations

A T cell-specific enhancer is located in a DNase I-hypersensitive area at the 3′ end of the CD3-delta gene.

1988 • 81 citations

The functional domains of the murine Thy-1 gene promoter.

1991 • 77 citations

An enhancer located in a CpG-island 3′ to the TCR/CD3-epsilon gene confers T lymphocyte-specificity to its promoter.

1989 • 59 citations

Identification of a T-cell-specific enhancer at the locus encoding T-cell antigen receptor gamma chain.

1991 • 42 citations

T Cell Signaling

1989 • 30 citations