Molecular coordination of αβ T-cell receptors and coreceptors CD8 and CD4 in their recognition of peptide-MHC ligands

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

The Immunological Synapse

2001 • 987 citations

LIGAND RECOGNITION BY αβ T CELL RECEPTORS

1998 • 904 citations

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 • 695 citations

Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen

1998 • 685 citations

The T Cell Receptor as a Multicomponent Signalling Machine: CD4/CD8 Coreceptors and CD45 in T Cell Activation

1992 • 539 citations

CD8 is needed for development of cytotoxic T but not helper T cells

1991 • 528 citations

Crystal structure of the complex between human CD8αα and HLA-A2

1997 • 471 citations

Cell-cell adhesion mediated by CD8 and MHC class I molecules

1988 • 445 citations

Molecular Biology and Function of CD4 and CD8

1989 • 388 citations

MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8

1992 • 368 citations

CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes

1996 • 326 citations

TCR Binding to Peptide-MHC Stabilizes a Flexible Recognition Interface

1999 • 306 citations

The immunological synapse and CD28-CD80 interactions

2001 • 303 citations

T Cell Responses Modulated Through Interaction Between CD8αα and the Nonclassical MHC Class I Molecule, TL

2001 • 257 citations

T Cell Receptor–MHC Interactions up Close

2001 • 252 citations

A kinase-independent function of Lck in potentiating antigen-specific T cell activation

1993 • 252 citations

Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule

2001 • 231 citations

CD8β Endows CD8 with Efficient Coreceptor Function by Coupling T Cell Receptor/CD3 to Raft-associated CD8/p56lck Complexes

2001 • 213 citations

Crystal structure of a T cell receptor bound to an allogeneic MHC molecule

2000 • 208 citations

LIGAND RECOGNITION BY T CELL RECEPTORS

1998 • 207 citations

Structure of a Complex of the Human α/β T Cell Receptor (TCR) HA1.7, Influenza Hemagglutinin Peptide, and Major Histocompatibility Complex Class II Molecule, HLA-DR4 (DRA0101 and DRB10401)

2002 • 206 citations

A T Cell Receptor CDR3β Loop Undergoes Conformational Changes of Unprecedented Magnitude Upon Binding to a Peptide/MHC Class I Complex

2002 • 206 citations

Developmentally Regulated Glycosylation of the CD8αβ Coreceptor Stalk Modulates Ligand Binding

2001 • 200 citations

T Cell Receptor and Coreceptor CD8αα Bind Peptide-MHC Independently and with Distinct Kinetics

1999 • 194 citations

CD8 Binding to MHC Class I Molecules Is Influenced by T Cell Maturation and Glycosylation

2001 • 187 citations

Structural Basis of CD8 Coreceptor Function Revealed by Crystallographic Analysis of a Murine CD8αα Ectodomain Fragment in Complex with H-2Kb

1998 • 185 citations

Dynamics of the immunological synapse: finding, establishing and solidifying a connection

2002 • 184 citations

Essential Role of CD8 Palmitoylation in CD8 Coreceptor Function

2000 • 178 citations

Thermodynamics of T cell receptor binding to peptide–MHC: Evidence for a general mechanism of molecular scanning

1999 • 178 citations

Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor

2000 • 161 citations

The Human CD8 Coreceptor Effects Cytotoxic T Cell Activation and Antigen Sensitivity Primarily by Mediating Complete Phosphorylation of the T Cell Receptor ζ Chain

2001 • 155 citations

Efficient detection and immunomagnetic sorting of specific T cells using multimers of MHC class I and peptide with reduced CD8 binding

2000 • 155 citations

Inhibition of T Cell Receptor-Coreceptor Interactions by Antagonist Ligands Visualized by Live FRET Imaging of the T-Hybridoma Immunological Synapse

2002 • 132 citations

Formation of supramolecular activation clusters on freshex vivoCD8⁺T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells

2001 • 131 citations

Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex.

1995 • 130 citations

Killer Cell Immunoglobulin Receptors and T Cell Receptors Bind Peptide-Major Histocompatibility Complex Class I with Distinct Thermodynamic and Kinetic Properties

1999 • 122 citations

Physical association of CD4 with the T cell receptor.

1992 • 116 citations

Co-stimulation and counter-stimulation: lipid raft clustering controls TCR signaling and functional outcomes

2001 • 107 citations

Identification of palmitoylation sites on CD4, the human immunodeficiency virus receptor.

1992 • 105 citations

T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4

2001 • 103 citations

The CD8 coreceptor revisited: One chain good, two chains better

1994 • 99 citations

Familial CD8 deficiency due to a mutation in the CD8α gene

2001 • 94 citations

Oligomerization of CD4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gp120.

1995 • 94 citations

Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice.

1994 • 82 citations

A Novel Approach to Antigen-Specific Deletion of CTL with Minimal Cellular Activation Using α3 Domain Mutants of MHC Class I/Peptide Complex

2001 • 77 citations

The Immunological Synapse--a Multitasking System

2002 • 72 citations

The two membrane proximal domains of CD4 interact with the T cell receptor.

1996 • 69 citations

A computer screening approach to immunoglobulin superfamily structures and interactions: Discovery of small non-peptidic CD4 inhibitors as novel immunotherapeutics

1997 • 65 citations

Profound Enhancement of T Cell Activation Mediated by the Interaction Between the TCR and the D3 Domain of CD4

1999 • 51 citations

Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade

1998 • 45 citations

Antagonism of cytotoxic T-lymphocyte activation by soluble CD8

1999 • 45 citations

Peptides corresponding to the CD8 and CD4 binding domains of HLA molecules block T lymphocyte immune responses in vitro.

1994 • 38 citations

A structure-based approach to designing synthetic CD8α peptides that can inhibit cytotoxic T-lymphocyte responses

1998 • 21 citations

Novel CD8+ T Cell Antagonists Based on β2-Microglobulin

2002 • 18 citations

An Organic CD4 Inhibitor Reduces the Clinical and Pathological Symptoms of Acute Experimental Allergic Encephalomyelitis

2002 • 17 citations

Measuring very low affinity interactions between immunoglobulin superfamily cell-adhesion molecules

1993 • 14 citations

Effect of a cyclic heptapeptide based on the human CD4 domain 1 CC′ loop region on murine experimental allergic encephalomyelitis: inhibition of both primary and secondary responses

2001 • 10 citations

A Synthetic CD4-CDR3 Peptide Analog Enhances Skin Allograft Survival Across a MHC Class II Barrier

1998 • 8 citations

Peptides corresponding to the CD8 binding region of HLA class I block the differentiation of cytotoxic T lymphocyte precursors.

1993 • 8 citations