Chemopreventive and therapeutic effects of curcumin

Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.

2001 • 2,024 citations

The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse

2001 • 1,482 citations

Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element

2003 • 989 citations

Protein kinase C signaling and oxidative stress

2000 • 691 citations

Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor–κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis

2003 • 678 citations

Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances

1999 • 649 citations

Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis.

1991 • 571 citations

Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt

2003 • 435 citations

Curcumin Is an In Vivo Inhibitor of Angiogenesis

1998 • 406 citations

Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin

1998 • 399 citations

Curcumin Induces Apoptosis in Human Melanoma Cells through a Fas Receptor/Caspase-8 Pathway Independent of p53

2001 • 379 citations

Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer.

2002 • 321 citations

Curcumin exerts multiple suppressive effects on human breast carcinoma cells

2001 • 312 citations

Dietary Supplementation of Curcumin Enhances Antioxidant and Phase II Metabolizing Enzymes in ddY Male Mice: Possible Role in Protection against Chemical Carcinogenesis and Toxicity

2003 • 311 citations

Chemopreventive effect of turmeric against stomach and skin tumors induced by chemical carcinogens in Swiss mice

1992 • 299 citations

Genistein exerts multiple suppressive effects on human breast carcinoma cells.

1998 • 293 citations

Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF- B activation through inhibition of I B kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1

2003 • 288 citations

Curcumin Inhibits Experimental Allergic Encephalomyelitis by Blocking IL-12 Signaling Through Janus Kinase-STAT Pathway in T Lymphocytes

2002 • 287 citations

Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-κB-dependent genes

2003 • 282 citations

Dual inhibitors of cyclooxygenase and 5-lipoxygenase. A new avenue in anti-inflammatory therapy? 1 1Abbreviations: NSAIDs, nonsteroidal anti-inflammatory drugs; COX, cyclooxygenase; LT, leukotriene; 5-LOX, 5-lipoxygenase; PG, prostaglandin; DFU, 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsuphonyl)-phenyl-2(5H)-furanone; and DFP, diisopropyl fluorophosphate.

2001 • 277 citations

Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaBalpha: correlation with induction of cyclooxygenase-2

2002 • 273 citations

Inhibitory effects of curcumin on protein kinase C activity induced by 12-O-tetradecanoyl-phorbol-13-acetate in NIH 3T3 cells

1993 • 252 citations

Protective Effects of Curcumin against Oxidative Damage on Skin Cells In Vitro: Its Implication for Wound Healing

2001 • 248 citations

Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver

1998 • 246 citations

Molecular mechanisms of anti-angiogenic effect of curcumin

2002 • 245 citations

Effect of Curcumin on the Aryl Hydrocarbon Receptor and Cytochrome P450 1A1 in MCF-7 Human Breast Carcinoma Cells

1998 • 238 citations

Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver

1996 • 235 citations

Inhibition of Proteasomal Function by Curcumin Induces Apoptosis through Mitochondrial Pathway

2004 • 231 citations

Curcumin is a non‐competitive and selective inhibitor of phosphorylase kinase

1994 • 222 citations

Induction of Apoptosis by Garcinol and Curcumin through Cytochrome c Release and Activation of Caspases in Human Leukemia HL-60 Cells

2001 • 214 citations

Curcumin Suppresses Activation of NF-κB and AP-1 Induced by Phorbol Ester in Cultured Human Promyelocytic Leukemia Cells

2002 • 197 citations

Curcumin attenuates DNB-induced murine colitis

2003 • 196 citations

Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells

2003 • 191 citations

Mechanistic considerations in chemopreventive drug development

1994 • 176 citations

Curcumin alters EpRE and AP‐1 binding complexes and elevates glutamate‐cysteine ligase gene expression

2003 • 168 citations

Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo

2001 • 167 citations

The Dietary Pigment Curcumin Reduces Endothelial Tissue Factor Gene Expression by Inhibiting Binding of AP-1 to the DNA and Activation of NF-κB

1997 • 165 citations

Curcumin inhibits telomerase activity through human telomerase reverse transcritpase in MCF-7 breast cancer cell line

2002 • 162 citations

Basal levels and patterns of anticancer drug-induced activation of nuclear factor-κB (NF-κB), and its attenuation by tamoxifen, dexamethasone, and curcumin in carcinoma cells

2002 • 159 citations

Curcumin ameliorates ethanol and nonethanol experimental pancreatitis

2003 • 156 citations

Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin

1997 • 155 citations

Inhibition of growth and sensitization to cisplatin-mediated killing of ovarian cancer cells by polyphenolic chemopreventive agents

2002 • 138 citations

A Novel Apoptosis-like Pathway, Independent of Mitochondria and Caspases, Induced by Curcumin in Human Lymphoblastoid T (Jurkat) Cells

1999 • 132 citations

Induction of apoptosis by curcumin: mediation by glutathione S-transferase P1-1 inhibition

2003 • 130 citations

Inhibition of Tissue Factor Gene Activation in Cultured Endothelial Cells by Curcumin

1997 • 127 citations

Inhibitory effects of curcumin and capsaicin on phorbol ester‐induced activation of eukaryotic transcription factors, NF‐κB and AP‐1

2000 • 126 citations

Curcumin inhibits IL1 alpha and TNF-alpha induction of AP-1 and NF-kB DNA-binding activity in bone marrow stromal cells.

1997 • 125 citations

Effect of curcumin on galactose-induced cataractogenesis in rats.

2003 • 125 citations

Inhibition of cell survival signal protein kinase B/Akt by curcumin in human prostate cancer cells

2003 • 122 citations

Human colon cancer cells differ in their sensitivity to curcumin‐induced apoptosis and heat shock protects them by inhibiting the release of apoptosis‐inducing factor and caspases

2003 • 120 citations

Inhibition of glutathione S-transferase activity in human melanoma cells by α,β-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal

1996 • 112 citations

Chemopreventive efficacy of lycopene on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis

2001 • 110 citations

Ruthenium red, inhibitor of mitochondrial Ca2+ uniporter, inhibits curcumin-induced apoptosis via the prevention of intracellular Ca2+ depletion and cytochrome c release

2003 • 106 citations

Curcumin-Induced Apoptosis in Scleroderma Lung Fibroblasts

2004 • 98 citations

Curcumin activates the aryl hydrocarbon receptor yet significantly inhibits (-)-benzo(a)pyrene-7R-trans-7,8-dihydrodiol bioactivation in oral squamous cell carcinoma cells and oral mucosa.

2002 • 90 citations

Inhibitors of cyclooxygenase-2 and 5-lipoxygenase

1997 • 90 citations

Protective single/combined treatment with betel leaf and turmeric against methyl (acetoxymethyl) nitrosamine‐induced hamster oral carcinogenesis

1992 • 85 citations

Mechanism of heme oxygenase-1 gene induction by curcumin in human renal proximal tubule cells

2001 • 84 citations

Effect of glutathione depletion on caspase-3 independent apoptosis pathway induced by curcumin in Jurkat cells

2001 • 83 citations

Coffee and its chemopreventive components Kahweol and Cafestol increase the activity of O6-methylguanine-DNA methyltransferase in rat liver—comparison with phase II xenobiotic metabolism

2003 • 81 citations

The chemopreventive compound curcumin is an efficient inhibitor of Epstein‐Barr virus BZLF1 transcription in Raji DR‐LUC cells*

2002 • 80 citations

Induction of Apoptosis in Tumor Cells by Natural Phenolic Compounds.

2002 • 75 citations

Chemopreventive effects of curcumin on glandular stomach carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride in rats.

2002 • 73 citations

No prevention of liver and kidney tumors in Long–Evans Cinnamon rats by dietary curcumin, but inhibition at other sites and of metastases

2003 • 72 citations

Anticarcinogenic effect of bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione a curcumin analog on DMH-induced colon cancer model

2003 • 65 citations

Mechanism of heme oxygenase-1 gene induction by curcumin in human renal proximal tubule cells

2001 • 55 citations

Action of curcumin on the cytochrome P450-system catalyzing the activation of aflatoxin B1

1996 • 49 citations

Curcumin‐Induced Cell Death in Two Leukemia Cell Lines: K562 and Jurkat

2003 • 47 citations

Chemopreventive effects of emodin and cassiamin B in mouse skin carcinogenesis

2002 • 45 citations

Curcumin Induces Caspase‐3‐Independent Apoptosis in Human Multidrug‐Resistant Cells

2002 • 43 citations

Suppression of Altered Hepatic Foci Development by Curcumin in Wistar Rats

2003 • 32 citations