Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaBalpha: correlation with induction of cyclooxygenase-2

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

Activators and Target Genes of Rel/NF-кB Transcription Factors

2003 • 3,164 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Tobacco Smoke Carcinogens and Lung Cancer

1999 • 1,927 citations

Preferential Formation of Benzo[ a ]pyrene Adducts at Lung Cancer Mutational Hotspots in P53

1996 • 1,636 citations

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

1997 • 1,411 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

1998 • 1,062 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis

1999 • 922 citations

Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas.

1998 • 825 citations

The Less Harmful Cigarette: A Controversial Issue. A Tribute to Ernst L. Wynder

2001 • 730 citations

Tyrosine Phosphorylation of IκB-α Activates NF-κB without Proteolytic Degradation of IκB-α

1996 • 665 citations

Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-κB activation via the NIK/IKK signalling complex

1999 • 638 citations

In vivo transfection of cis element “decoy” against nuclear factor- κB binding site prevents myocardial infarction

1997 • 601 citations

Annual Report to the Nation on the Status of Cancer, 1973-1996, With a Special Section on Lung Cancer and Tobacco Smoking

1999 • 597 citations

NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules.

1997 • 576 citations

The NF-κB signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation

2000 • 545 citations

RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis.

1996 • 540 citations

Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor.

2000 • 494 citations

Cyclooxygenase-2 and carcinogenesis

2000 • 489 citations

Cigarette smoke radicals and the role of free radicals in chemical carcinogenicity.

1997 • 451 citations

Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms

1998 • 431 citations

Activation of NF-κB by RANK Requires Tumor Necrosis Factor Receptor-associated Factor (TRAF) 6 and NF-κB-inducing Kinase

1999 • 399 citations

The essential role of MEKK3 in TNF-induced NF-κB activation

2001 • 389 citations

Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation

1997 • 375 citations

Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines.

1988 • 306 citations

Fractionation of Aqueous Cigarette Tar Extracts: Fractions That Contain the Tar Radical Cause DNA Damage

1998 • 302 citations

Crucial Role of the Amino-Terminal Tyrosine Residue 42 and the Carboxyl-Terminal PEST Domain of IκBα in NF-κB Activation by an Oxidative Stress

2000 • 251 citations

An international literature survey of “IARC group I carcinogens” reported in mainstream cigarette smoke

1997 • 248 citations

Early activation of transcription factor NF-κB during ischemia in perfused rat heart

1999 • 213 citations

Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor ?B independently of I?B degradation

1998 • 181 citations

Differential IκB Kinase Activation and IκBα Degradation by Interleukin-1β and Tumor Necrosis Factor-α in Human U937 Monocytic Cells

1999 • 165 citations

Quantitative analysis of the hydrogen peroxide formed in aqueous cigarette tar extracts

1989 • 165 citations

Oxidative Stress Induces NF- B Nuclear Translocation Without Degradation of I B

1999 • 164 citations

Cigarette smoke condensate-induced adhesion molecule expression and transendothelial migration of monocytes

1996 • 164 citations

Activation of NF-kappaB/Rel occurs early during neoplastic transformation of mammary cells

2000 • 158 citations

The α and β Subunits of IκB Kinase (IKK) Mediate TRAF2-Dependent IKK Recruitment to Tumor Necrosis Factor (TNF) Receptor 1 in Response to TNF

2001 • 149 citations

Mechanism of cigarette smoke condensate induced adhesion of human monocytes to cultured endothelial cells

1994 • 147 citations

Tyrosine phosphorylation‐dependent activation of NF‐κB

2001 • 131 citations

Distinct signal transduction pathways mediate nuclear factor-kappaB induction by IL-1beta in epithelial and lymphoid cells.

1997 • 129 citations

Correlation between Nuclear Factor- κ B Activity in Bronchial Brushing Samples and Lung Dysfunction in an Animal Model of Asthma

2000 • 122 citations

The PTEN Tumor Suppressor Protein Inhibits Tumor Necrosis Factor-induced Nuclear Factor κB Activity

2001 • 113 citations

Benzo[a]pyrene Induces the Transcription of Cyclooxygenase-2 in Vascular Smooth Muscle Cells

2000 • 111 citations

A tobacco-specific N-nitrosamine or cigarette smoke condensate causes neoplastic transformation of xenotransplanted human bronchial epithelial cells.

1992 • 102 citations

IFN-α Suppresses Activation of Nuclear Transcription Factors NF-κB and Activator Protein 1 and Potentiates TNF-Induced Apoptosis

2000 • 99 citations

A novel strategy for myocardial protection using in vivo transfection of cis element 'decoy' against NFkappaB binding site: evidence for a role of NFkappaB in ischemia-reperfusion injury.

1997 • 91 citations

Benzo[a]pyrene Activates the Human p53 Gene through Induction of Nuclear Factor κB Activity

1999 • 89 citations

Correlation of Expression of Cyclooxygenase-2, Vascular Endothelial Growth Factor, and Peroxisome Proliferator–Activated Receptor δ With Head and Neck Squamous Cell Carcinoma

2001 • 78 citations

Cancer in developing countries.

1994 • 77 citations

Pervanadate-induced Nuclear Factor-κB Activation Requires Tyrosine Phosphorylation and Degradation of IκBα

2000 • 73 citations

I kappa B alpha degradation is not a requirement for the X-ray-induced activation of nuclear factor kappa B in normal rat astrocytes and human brain tumour cells

1998 • 48 citations

The Activity of NF-kappaB in Swiss 3T3 Cells Exposed to Aqueous Extracts of Cigarette Smoke Is Dependent on Thioredoxin

2001 • 46 citations

Role of the protein kinase C λ/ι isoform in nuclear factor-κB activation by interleukin-1β or tumor necrosis factor-α: cell type specificities

1999 • 43 citations

Free radical pathology: Inactivation of human α-1-proteinase inhibitor by products from the reaction of nitrogen dioxide with hydrogen peroxide and the etiology of emphysema

1982 • 42 citations

Lung Tumorigenicity of NNK Given Orally to A/J Mice: Its Application to Chemopreventive Efficacy Studies

1991 • 37 citations

NUCLEAR FACTOR-??B TRANSCRIPTION FACTOR DECOY TREATMENT INHIBITS GRAFT CORONARY ARTERY DISEASE AFTER CARDIAC TRANSPLANTATION IN RODENTS1

2000 • 31 citations

Inhalation toxicity studies on cigarette smoke IV. expression of the dose of smoke particulate material applied to the lungs of experimental animals

1977 • 29 citations

Spin Trapping of Nitric Oxide in Aqueous Solutions of Cigarette Smoke

1998 • 25 citations

Comparison of Aliquot and Complete Sample Procedure for the Determination of Nicotine in Cigarette Smoke

1972 • 14 citations

Benzo[α]pyrene Activates the Human p53 Gene through Induction of Nuclear Factor κB Activity

2000 • 6 citations