Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF- B activation through inhibition of I B kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

Cancer Statistics, 2001

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Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.

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Tobacco Smoke Carcinogens and Lung Cancer

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Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers

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Preferential Formation of Benzo[ a ]pyrene Adducts at Lung Cancer Mutational Hotspots in P53

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Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

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Clinical Cancer Research

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Activation of Transcription Factor NF-κB Is Suppressed by Curcumin (Diferuloylmethane)

1995 • 1,352 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis

1999 • 922 citations

NF-κB as a Therapeutic Target in Multiple Myeloma

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Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas.

1998 • 825 citations

Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer.

2001 • 817 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

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The Less Harmful Cigarette: A Controversial Issue. A Tribute to Ernst L. Wynder

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Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity.

1999 • 719 citations

Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.

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Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor–κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis

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Potential anticancer activity of turmeric (Curcuma longa)

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Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-κB activation via the NIK/IKK signalling complex

1999 • 638 citations

Curcumin Blocks Cytokine-Mediated NF-κB Activation and Proinflammatory Gene Expression by Inhibiting Inhibitory Factor I-κB Kinase Activity

1999 • 616 citations

Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer.

1999 • 595 citations

Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor.

2000 • 494 citations

Cyclooxygenase-2 and carcinogenesis

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Release and Activity of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 by Alveolar Macrophages from Patients with Chronic Obstructive Pulmonary Disease

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Nuclear transcription factor-κB as a target for cancer drug development

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Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms

1998 • 431 citations

Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation

1997 • 375 citations

Alterations in the Local Myocardial Motion Pattern in Patients Suffering From Pressure Overload Due to Aortic Stenosis

1999 • 374 citations

Biochimica et biophysica acta. Protein structure and molecular enzymology

2002 • 370 citations

Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of IκB kinase and NFκB activation in macrophages

2000 • 356 citations

The influence of cigarette smoking on circulating concentrations of antioxidant micronutrients

2002 • 349 citations

Curcumin inhibits cyclooxygenase-2 transcription in bile acid- and phorbol ester-treated human gastrointestinal epithelial cells

1999 • 288 citations

Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaBalpha: correlation with induction of cyclooxygenase-2

2002 • 273 citations

Curcuminoids Inhibit the Angiogenic Response Stimulated by Fibroblast Growth Factor-2, Including Expression of Matrix Metalloproteinase Gelatinase B

2000 • 273 citations

Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasis

2000 • 268 citations

Crucial Role of the Amino-Terminal Tyrosine Residue 42 and the Carboxyl-Terminal PEST Domain of IκBα in NF-κB Activation by an Oxidative Stress

2000 • 251 citations

Curcumin (Diferuloylmethane) Inhibition of Tumor Necrosis Factor (TNF)-Mediated Adhesion of Monocytes to Endothelial Cells by Suppression of Cell Surface Expression of Adhesion Molecules and of Nuclear Factor-κB Activation

1998 • 243 citations

Nuclear Factor-κB Activation: A Question of Life or Death

2002 • 241 citations

Methotrexate Suppresses NF-κB Activation Through Inhibition of IκBα Phosphorylation and Degradation

2001 • 189 citations

Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor ?B independently of I?B degradation

1998 • 181 citations

Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase.

2000 • 180 citations

Proteasome inhibition in cancer: Development of PS-341

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[53] Assay for redox-sensitive transcription factor

2000 • 177 citations

Differential IκB Kinase Activation and IκBα Degradation by Interleukin-1β and Tumor Necrosis Factor-α in Human U937 Monocytic Cells

1999 • 165 citations

Oxidative Stress Induces NF- B Nuclear Translocation Without Degradation of I B

1999 • 164 citations

Thalidomide Suppresses NF-κB Activation Induced by TNF and H2O2, But Not That Activated by Ceramide, Lipopolysaccharides, or Phorbol Ester

2002 • 162 citations

Activation of NF-kappaB/Rel occurs early during neoplastic transformation of mammary cells

2000 • 158 citations

Tyrosine phosphorylation‐dependent activation of NF‐κB

2001 • 131 citations

Distinct signal transduction pathways mediate nuclear factor-kappaB induction by IL-1beta in epithelial and lymphoid cells.

1997 • 129 citations

A tobacco-specific N-nitrosamine or cigarette smoke condensate causes neoplastic transformation of xenotransplanted human bronchial epithelial cells.

1992 • 102 citations

IFN-α Suppresses Activation of Nuclear Transcription Factors NF-κB and Activator Protein 1 and Potentiates TNF-Induced Apoptosis

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Thalidomide in the management of multiple myeloma

2001 • 93 citations

Correlation of Expression of Cyclooxygenase-2, Vascular Endothelial Growth Factor, and Peroxisome Proliferator–Activated Receptor δ With Head and Neck Squamous Cell Carcinoma

2001 • 78 citations

Pervanadate-induced Nuclear Factor-κB Activation Requires Tyrosine Phosphorylation and Degradation of IκBα

2000 • 73 citations

Morphological changes in lungs, placenta, liver and kidneys of pregnant rats exposed to cigarette smoke

2002 • 68 citations

Organ heterogeneity of host-derived matrix metalloproteinase expression and its involvement in multiple-organ metastasis by lung cancer cell lines.

2002 • 58 citations

I kappa B alpha degradation is not a requirement for the X-ray-induced activation of nuclear factor kappa B in normal rat astrocytes and human brain tumour cells

1998 • 48 citations

Induction of cyclo-oxygenase-2 in non-small cell lung cancer cells by infection with ΔE1, ΔE3 recombinant adenovirus vectors

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Comparison of Aliquot and Complete Sample Procedure for the Determination of Nicotine in Cigarette Smoke

1972 • 14 citations

Deleted Work

1955 • 0 citations