A Genetic Approach to Mammalian Glycan Function

Biological roles of oligosaccharides: all of the theories are correct

1993 • 5,121 citations

ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES

1985 • 4,790 citations

Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate

2002 • 1,437 citations

Setting the Standards: Quality Control in the Secretory Pathway

1999 • 1,198 citations

Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens

1985 • 1,184 citations

Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG

1985 • 1,136 citations

GLYCOBIOLOGY

1988 • 1,107 citations

Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning

1994 • 1,010 citations

Glycosylation of Nucleocytoplasmic Proteins: Signal Transduction and O-GlcNAc

2001 • 945 citations

β1-6 Branching of Asn-Linked Oligosaccharides Is Directly Associated with Metastasis

1987 • 929 citations

Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme

2000 • 864 citations

Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation

2001 • 852 citations

Fringe is a glycosyltransferase that modifies Notch

2000 • 846 citations

Post-translational disruption of dystroglycan–ligand interactions in congenital muscular dystrophies

2002 • 775 citations

The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny

2000 • 773 citations

The diastrophic dysplasia gene encodes a novel sulfate transporter: Positional cloning by fine-structure linkage disequilibrium mapping

1994 • 751 citations

Glycosylation changes of IgG associated with rheumatooid arthritis can activate complement via the mannose-binding protein

1995 • 742 citations

Dynamic O-Glycosylation of Nuclear and Cytosolic Proteins

2001 • 727 citations

The α(1,3)Fucosyltransferase Fuc-TVII Controls Leukocyte Trafficking through an Essential Role in L-, E-, and P-selectin Ligand Biosynthesis

1996 • 723 citations

Dynamic Glycosylation of Nuclear and Cytosolic Proteins

1997 • 719 citations

Muscular Dystrophy and Neuronal Migration Disorder Caused by Mutations in a Glycosyltransferase, POMGnT1

2001 • 706 citations

Glycosyltransferase activity of Fringe modulates Notch–Delta interactions

2000 • 686 citations

Glycoprotein glycosylation and cancer progression

1999 • 648 citations

The Molecular Basis of Blood Diseases.

1987 • 648 citations

The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research

1999 • 622 citations

Myelination in the Absence of Galactocerebroside and Sulfatide: Normal Structure with Abnormal Function and Regional Instability

1996 • 601 citations

PSA–NCAM Is Required for Activity-Induced Synaptic Plasticity

1996 • 582 citations

The six hyaluronidase-like genes in the human and mouse genomes

2001 • 578 citations

A mutation in human CMP-sialic acid hydroxylase occurred after theHomo-Pandivergence

1998 • 554 citations

Suppression of tumor growth and metastasis in Mgat5-deficient mice

2000 • 542 citations

The Cloning of PIG-A, a Component in the Early Step of GPI-Anchor Biosynthesis

1993 • 528 citations

O-Linked GlcNAc Transferase Is a Conserved Nucleocytoplasmic Protein Containing Tetratricopeptide Repeats

1997 • 525 citations

Sialic Acid Species as a Determinant of the Host Range of Influenza A Viruses

2000 • 507 citations

Evolutionary considerations in relating oligosaccharide diversity to biological function

1999 • 497 citations

A vital role for glycosphingolipid synthesis during development and differentiation

1999 • 482 citations

Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme

1999 • 478 citations

PROTEIN GLYCOSYLATION IN YEAST

1987 • 437 citations

Carbohydrate-deficient glycoprotein syndrome type Ib. Phosphomannose isomerase deficiency and mannose therapy.

1998 • 428 citations

Disruption of Gastrulation and Heparan Sulfate Biosynthesis in EXT1-Deficient Mice

2000 • 408 citations

Primary structure of beta-galactoside alpha 2,6-sialyltransferase. Conversion of membrane-bound enzyme to soluble forms by cleavage of the NH2-terminal signal anchor.

1987 • 408 citations

Defects in somite formation in lunatic fringe-deficient mice

1998 • 405 citations

Oocyte Galα1,3Gal Epitopes Implicated in Sperm Adhesion to the Zona Pellucida Glycoprotein ZP3 Are Not Required for Fertilization in the Mouse

1995 • 399 citations

Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects

1999 • 396 citations

Mice lacking N-acetylglucosaminyltransferase I activity die at mid-gestation, revealing an essential role for complex or hybrid N-linked carbohydrates.

1994 • 395 citations

Structures of Sialylated O-Linked Oligosaccharides of Bovine Peripheral Nerve α-Dystroglycan

1997 • 388 citations

Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2

2000 • 377 citations

Peroxynitrite Inhibits Glutamate Transporter Subtypes

1996 • 375 citations

Lectin-like proteins in model organisms: implications for evolution of carbohydrate-binding activity

2001 • 374 citations

Recruitment of O-GlcNAc Transferase to Promoters by Corepressor mSin3A

2002 • 373 citations

Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system.

1996 • 371 citations

Mutations in PMM2, a phosphomannomutase gene on chromosome 16p13 in carbohydrate-deficient glycoprotein type I syndrome (Jaeken syndrome)

1997 • 355 citations

Immune regulation by the ST6Gal sialyltransferase

1998 • 352 citations

Phosphomannomutase deficiency is a cause of carbohydrate‐deficient glycoprotein syndrome type I

1995 • 351 citations

Protein glycosylation in yeast

1987 • 339 citations

Sialylation is essential for early development in mice

2002 • 338 citations

Complex asparagine-linked oligosaccharides are required for morphogenic events during post-implantation development.

1994 • 336 citations

Tokyo campus rising

1998 • 336 citations

Mammalian Notch1 Is Modified with Two Unusual Forms ofO-Linked Glycosylation Found on Epidermal Growth Factor-like Modules

2000 • 335 citations

Characterization and Molecular Evolution of a Vertebrate Hyaluronan Synthase Gene Family

1998 • 335 citations

Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebroside synthesis

1996 • 335 citations

Novel Sulfated Lymphocyte Homing Receptors and Their Control by a Core1 Extension β1,3-N-Acetylglucosaminyltransferase

2001 • 327 citations

Fibroblasts from patients with I-cell disease and pseudo-Hurler polydystrophy are deficient in uridine 5'-diphosphate-N-acetylglucosamine: glycoprotein N-acetylglucosaminylphosphotransferase activity.

1981 • 323 citations

Polysialic acid as a regulator of intramuscular nerve branching during embryonic development

1990 • 319 citations

The α(1,3)fucosyltransferases FucT-IV and FucT-VII Exert Collaborative Control over Selectin-Dependent Leukocyte Recruitment and Lymphocyte Homing

2001 • 315 citations

Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen.

1992 • 312 citations

Heparan sulfate: growth control with a restricted sequence menu

2001 • 310 citations

Core 2 Oligosaccharide Biosynthesis Distinguishes between Selectin Ligands Essential for Leukocyte Homing and Inflammation

1998 • 308 citations

Mice Deficient in the Polysialyltransferase ST8SiaIV/PST-1 Allow Discrimination of the Roles of Neural Cell Adhesion Molecule Protein and Polysialic Acid in Neural Development and Synaptic Plasticity

2000 • 307 citations

THE ??-1,3-GALACTOSYLTRANSFERASE KNOCKOUT MOUSE

1996 • 306 citations

Gene sequences suggest inactivation of alpha-1,3-galactosyltransferase in catarrhines after the divergence of apes from monkeys.

1991 • 304 citations

Mutant glycosyltransferase and altered glycosylation of α-dystroglycan in the myodystrophy mouse

2001 • 301 citations

The ST3Gal-I Sialyltransferase Controls CD8+ T Lymphocyte Homeostasis by Modulating O-Glycan Biosynthesis

2000 • 301 citations

von Willebrand Disease

1997 • 300 citations

Neurite outgrowth in response to transfected N-CAM changes during development and is modulated by polysialic acid

1990 • 299 citations

Protein O-mannosylation

1999 • 295 citations

Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene

2000 • 294 citations

Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions

1999 • 291 citations

Molecular characterization of eukaryotic polysialyltransferase-1

1995 • 286 citations

Correction of Leukocyte Adhesion Deficiency Type II With Oral Fucose

1999 • 274 citations

Growth retardation and early death of beta -1,4-galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells

1997 • 270 citations

T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination.

1995 • 266 citations

Bovine α1→3-Galactosyltransferase: Isolation and Characterization of a cDNA Clone

1989 • 264 citations

Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development

1997 • 263 citations

Sulfotransferases of Two Specificities Function in the Reconstitution of High Endothelial Cell Ligands for L-selectin

1999 • 260 citations

A family of UDP-GalNAc: polypeptide N-acetylgalactosaminyl-transferases control the initiation of mucin-type O-linked glycosylation

1996 • 248 citations

Glycosylation in the control of selectin counter‐receptor structure and function

2002 • 242 citations

Modification of Epidermal Growth Factor-like Repeats withO-Fucose

2001 • 240 citations

Defective Heparan Sulfate Biosynthesis and Neonatal Lethality in Mice LackingN-Deacetylase/N-Sulfotransferase-1

2000 • 239 citations

Glycosylphosphatidylinositol-anchor-deficient mice: implications for clonal dominance of mutant cells in paroxysmal nocturnal hemoglobinuria

1996 • 238 citations

Random determination of a developmental process: Reversal of normal visceral asymmetry in the mouse

1976 • 237 citations

Expression cloning of a human polysialyltransferase that forms the polysialylated neural cell adhesion molecule present in embryonic brain.

1995 • 237 citations

Achondrogenesis type IB is caused by mutations in the diastrophic dysplasia sulphate transporter gene

1996 • 235 citations

Deficient uridine diphosphate-N-acetylglucosamine:glycoprotein N-acetylglucosaminyltransferase activity in a clone of Chinese hamster ovary cells with altered surface glycoproteins.

1975 • 227 citations

Cloning and Expression of a Proteoglycan UDP-Galactose:β-Xylose β1,4-Galactosyltransferase I

1999 • 227 citations

Mice Expressing Only Monosialoganglioside GM3 Exhibit Lethal Audiogenic Seizures

2001 • 226 citations

Chinese hamster ovary cells selected for resistance to the cytotoxicity of phytohemagglutinin are deficient in a UDP-N-acetylglucosamine--glycoprotein N-acetylglucosaminyltransferase activity.

1975 • 222 citations

A Novel, High Endothelial Venule–Specific Sulfotransferase Expresses 6-Sulfo Sialyl Lewisx, an L-Selectin Ligand Displayed by CD34

1999 • 221 citations

Myelin Galactolipids Are Essential for Proper Node of Ranvier Formation in the CNS

1998 • 221 citations

Sperm from β1,4-galactosyltransferase-null mice are refractory to ZP3-induced acrosome reactions and penetrate the zona pellucida poorly

1997 • 220 citations

Characterization of the full length cDNA for murine beta-1,4-galactosyltransferase. Novel features at the 5′-end predict two translational start sites at two in-frame AUGs.

1988 • 217 citations

Isolation of a cDNA encoding a murine UDPgalactose:beta-D-galactosyl- 1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase: expression cloning by gene transfer.

1989 • 217 citations

Molecular Cloning and Expression of a Novel β-1,6-N-Acetylglucosaminyltransferase That Forms Core 2, Core 4, and I Branches

1999 • 216 citations

The α1-6-fucosyltransferase gene and its biological significance

1999 • 212 citations

The Tumor Suppressor EXT-like Gene EXTL2 Encodes an α1, 4-N-Acetylhexosaminyltransferase That TransfersN-Acetylgalactosamine and N-Acetylglucosamine to the Common Glycosaminoglycan-Protein Linkage Region

1999 • 201 citations

Developmentally Regulated Glycosylation of the CD8αβ Coreceptor Stalk Modulates Ligand Binding

2001 • 200 citations

Alpha-Mannosidase-II Deficiency Results in Dyserythropoiesis and Unveils an Alternate Pathway in Oligosaccharide Biosynthesis

1997 • 197 citations

The α-gal epitope (Galα1-3Galβ1-4GlcNAc-R) in xenotransplantation

2001 • 197 citations

Subversion of the T/B Lineage Decision in the Thymus by Lunatic Fringe-Mediated Inhibition of Notch-1

2001 • 195 citations

Molecular basis of variant pseudo-Hurler polydystrophy (mucolipidosis IIIC)

2000 • 195 citations

The ‘yellow brick road’ to branched complex N-glycans

1991 • 193 citations

Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands

2002 • 192 citations

Heparan sulfate: lessons from knockout mice

2001 • 192 citations

Primary structure of Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase determined by mass spectrometry sequence analysis and molecular cloning. Evidence for a protein motif in the sialyltransferase gene family.

1992 • 191 citations

Atelosteogenesis type II is caused by mutations in the diastrophic dysplasia sulfate-transporter gene (DTDST): evidence for a phenotypic series involving three chondrodysplasias.

1996 • 190 citations

Fringe, Notch, and making developmental boundaries

1999 • 189 citations

Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection.

1993 • 187 citations

A genetic defect in the biosynthesis of dermatan sulfate proteoglycan: galactosyltransferase I deficiency in fibroblasts from a patient with a progeroid syndrome.

1990 • 187 citations

Genetic remodeling of protein glycosylation in vivo induces autoimmune disease

2001 • 186 citations

EFFECT OF TUNICAMYCIN ON THE SYNTHESIS OF MACROMOLECULES IN CULTURES OF CHICK EMBRYO FIBROBLASTS INFECTED WITH NEWCASTLE DISEASE VIRUS

1971 • 185 citations

Glycopeptides from the Surface of Control and Virus-Transformed Cells

1971 • 179 citations

Glycoprotein synthesis and inhibition of glycosylation by tunicamycin in preimplantation mouse embryos: Compaction and trophoblast adhesion

1979 • 179 citations

Deficiency of dolichol-phosphate-mannose synthase-1 causes congenital disorder of glycosylation type Ie

2000 • 175 citations

Dolichol phosphate mannose synthase (DPM1) mutations define congenital disorder of glycosylation Ie (CDG-Ie)

2000 • 175 citations

The Molecular Phenotype of Heparan Sulfate in theHs2st−/− Mutant Mouse

2001 • 173 citations

Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode α1,4- N -acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis

2001 • 172 citations

Cloning and expression of N-acetylglucosaminyltransferase I, the medial Golgi transferase that initiates complex N-linked carbohydrate formation.

1990 • 171 citations

Developmental abnormalities of glycosylphosphatidylinositol-anchor-deficient embryos revealed by Cre/loxP system.

1999 • 169 citations

Notch Ligands Are Substrates for ProteinO-Fucosyltransferase-1 and Fringe

2002 • 168 citations

Targeted disruption of NDST‐1 gene leads to pulmonary hypoplasia and neonatal respiratory distress in mice

2000 • 166 citations

A Functional Role for Complex Gangliosides: Motor Deficits in GM2/GD2 Synthase Knockout Mice

2000 • 163 citations

Cloning and expression of the Gal beta 1, 3GalNAc alpha 2,3-sialyltransferase.

1992 • 163 citations

Mvwf, a Dominant Modifier of Murine von Willebrand Factor, Results from Altered Lineage-Specific Expression of a Glycosyltransferase

1999 • 162 citations

Polysialic acid and the regulation of cell interactions

1996 • 161 citations

Sulfation of L-Selectin Ligands by an HEV-Restricted Sulfotransferase Regulates Lymphocyte Homing to Lymph Nodes

2001 • 161 citations

Heparan sulfate: lessons from knockout mice

2001 • 159 citations

Mutations in the MGAT2 gene controlling complex N-glycan synthesis cause carbohydrate-deficient glycoprotein syndrome type II, an autosomal recessive disease with defective brain development.

1996 • 157 citations

Update and perspectives on congenital disorders of glycosylation

2001 • 155 citations

Molecular Basis for the Progeroid Variant of Ehlers-Danlos Syndrome

1999 • 155 citations

Conditional control of selectin ligand expression and global fucosylation events in mice with a targeted mutation at the FX locus

2002 • 154 citations

Germ Cell Survival Through Carbohydrate-Mediated Interaction with Sertoli Cells

2002 • 150 citations

Targeted Mutation in β1,4-Galactosyltransferase Leads to Pituitary Insufficiency and Neonatal Lethality

1997 • 148 citations

A member of a family of sulfate-activating enzymes causes murine brachymorphism

1998 • 148 citations

Sugar chains of serum transferrin from patients with carbohydrate deficient glycoprotein syndrome. Evidence of asparagine-N-linked oligosaccharide transfer deficiency.

1993 • 147 citations

The link between heparan sulfate and hereditary bone disease: finding a function for the EXT family of putative tumor suppressor proteins

2001 • 147 citations

MPDU1 mutations underlie a novel human congenital disorder of glycosylation, designated type If

2001 • 143 citations

Carbohydrate deficient glycoprotein syndrome type IV: deficiency of dolichyl-P-Man:Man5GlcNAc2-PP-dolichyl mannosyltransferase

1999 • 140 citations

Complex gangliosides are essential in spermatogenesis of mice: Possible roles in the transport of testosterone

1998 • 139 citations

Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis

2001 • 136 citations

Structure of serum transferrin in carbohydrate-deficient glycoprotein syndrome

1992 • 135 citations

Fringe modulation of Jagged1-induced Notch signaling requires the action of β4galactosyltransferase-1

2001 • 135 citations

Cloning and Expression of Human Galβ1,3(4)GlcNAc α2,3-Sialyltransferase

1993 • 133 citations

Sialyltransferase specificity in selectin ligand formation

2002 • 133 citations

Deficiency of UDP-galactose:N-acetylglucosamine β-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId

2002 • 133 citations

Cloning and Characterization of a New Human UDP-N-Acetyl-α-d-galactosamine:PolypeptideN-Acetylgalactosaminyltransferase, Designated pp-GalNAc-T13, That Is Specifically Expressed in Neurons and Synthesizes GalNAc α-Serine/Threonine Antigen

2002 • 133 citations

A recessive deletion in the GlcNAc-1-phosphotransferase gene results in peri-implantation embryonic lethality

1999 • 131 citations

Control of O-Glycan Branch Formation

2000 • 130 citations

Isolation, characterization, and expression of a cDNA encoding N-acetylglucosaminyltransferase V

1993 • 129 citations

Isolation, characterization, and expression of cDNAs encoding murine alpha-mannosidase II, a Golgi enzyme that controls conversion of high mannose to complex N-glycans.

1991 • 129 citations

A mutation in the human MPDU1 gene causes congenital disorder of glycosylation type If (CDG-If)

2001 • 127 citations

Molecular cloning and expression of cDNA encoding the enzyme that controls conversion of high-mannose to hybrid and complex N-glycans: UDP-N-acetylglucosamine: alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.

1991 • 121 citations

Underglycosylation of IgA1 Hinge Plays a Certain Role for Its Glomerular Deposition in IgA Nephropathy

1999 • 121 citations

Severe impairment of leukocyte rolling in venules of core 2 glucosaminyltransferase–deficient mice

2001 • 119 citations

Fuc-Tvii Is Required for T Helper 1 and T Cytotoxic 1 Lymphocyte Selectin Ligand Expression and Recruitment in Inflammation, and Together with Fuc-Tiv Regulates Naive T Cell Trafficking to Lymph Nodes

2001 • 118 citations

Carbohydrate-deficient glycoprotein syndrome type V: Deficiency of dolichyl- P -Glc:Man ₉ GlcNAc ₂ - PP -dolichyl glucosyltransferase

1998 • 117 citations

Cloning and expression of cDNA for a new type of Gal beta 1,3GalNAc alpha 2,3-sialyltransferase

1994 • 113 citations

Molecular cloning of a murine N-acetylgalactosamine transferase cDNA that determines expression of the T lymphocyte-specific CT oligosaccharide differentiation antigen.

1994 • 113 citations

Recent advances in gene mutagenesis by site-directed recombination.

1996 • 112 citations

A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic

1999 • 112 citations

Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of thePig-agene

1998 • 111 citations

A Cloned Human DNA Restriction Fragment Determines Expression of a GDP-L-fucose:β-D-Galactoside 2-α-L-fucosytransferase in Transfected Cells

1989 • 111 citations

Requirement of Seminolipid in Spermatogenesis Revealed by UDP-galactose:Ceramide Galactosyltransferase-deficient Mice

2000 • 108 citations

Characterization of a UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase That Displays Glycopeptide N-Acetylgalactosaminyltransferase Activity

1999 • 108 citations

Tn-syndrome

1999 • 107 citations

Incomplete synthesis of N-glycans in congenital dyserythropoietic anemia type II caused by a defect in the gene encoding alpha-mannosidase II.

1990 • 106 citations

Molecular basis of galactosemia: mutations and polymorphisms in the gene encoding human galactose-1-phosphate uridylyltransferase.

1991 • 106 citations

Primary defect of congenital dyserythropoietic anemia type II. Failure in glycosylation of erythrocyte lactosaminoglycan proteins caused by lowered N-acetylglucosaminyltransferase II.

1987 • 105 citations

Congenital Disorders of Glycosylation Type Ig Is Defined by a Deficiency in Dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl Mannosyltransferase

2002 • 105 citations

Cloning and Characterization of a Ninth Member of the UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase Family, ppGaNTase-T9

2001 • 105 citations

Carbohydrate-modifying Sulfotransferases: Structure, Function, and Pathophysiology

2001 • 103 citations

Expression Cloning and Characterization of a Novel Murine α1,3-Fucosyltransferase, mFuc-TIX, That Synthesizes the Lewis x (CD15) Epitope in Brain and Kidney

1998 • 103 citations

A New Trisaccharide Sugar Chain Linked to a Serine Residue in Bovine Blood Coagulation Factors VII and IX1

1988 • 103 citations

Deficiency of Reproductive Tract α(1,2)Fucosylated Glycans and Normal Fertility in Mice with Targeted Deletions of the FUT1 or FUT2 α(1,2)Fucosyltransferase Locus

2001 • 102 citations

Isolation, characterization and inactivation of the mouse Mgat3 gene: the bisecting N-acetylglucosamine in asparagine-linked oligosaccharides appears dispensable for viability and reproduction

1997 • 102 citations

Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme.

1995 • 98 citations

Modulation of receptor signaling by glycosylation: fringe is an O-fucose-β1,3-N-acetylglucosaminyltransferase

2002 • 97 citations

Genomic Cloning and Expression of Three Murine UDP-galactose: β-N-Acetylglucosamine β1,3-Galactosyltransferase Genes

1998 • 97 citations

Cloning of the galactokinase cDNA and identification of mutations in two families with cataracts

1995 • 95 citations

CD19, CD21, and CD22: Multifaceted Response Regulators of B Lymphocyte Signal Transduction

2001 • 95 citations

Differential requirements for the O-linked branching enzyme core 2 β1-6-N-glucosaminyltransferase in biosynthesis of ligands for E-selectin and P-selectin

2001 • 93 citations

ALG12 mannosyltransferase defect in congenital disorder of glycosylation type lg

2002 • 89 citations

Roles of O-linked oligosaccharides in immune responses

2000 • 88 citations

Molecular Cloning and Characterization of a Third Type of N-Glycan α2, 8-Sialyltransferase from Mouse Lung1

1995 • 81 citations

Reduced Body Weight and Increased Postimplantation Fetal Death in Tyrosylprotein Sulfotransferase-1-deficient Mice

2002 • 80 citations

Dynamic Epigenetic Regulation of InitialO-Glycosylation by UDP-N-Acetylgalactosamine:PeptideN-Acetylgalactosaminyltransferases

1999 • 79 citations

Control of Glycoprotein Synthesis

1989 • 78 citations

Composition of Drosophila melanogaster Proteome Involved in Fucosylated Glycan Metabolism

2002 • 78 citations

Carbohydrate‐deficient Glycoprotein Syndrome Type II

1995 • 77 citations

Effects of tunicamycin upon glycoprotein synthesis and development of early mouse embryos

1980 • 73 citations

CMP-N-Acetylneuraminic Acid Hydroxylase Is Exclusively Inactive in Humans

1998 • 69 citations

Characterization of Two Mutations Associated with Epimerase-Deficiency Galactosemia, by Use of a Yeast Expression System for Human UDP-Galactose-4-Epimerase

1997 • 64 citations

Charge Distribution of Flanking Amino Acids Influences O-Glycan Acquisition in Vivo

1996 • 64 citations

Molecular Cloning and Expression of cDNA Encoding the Rat UDP-N-Acetylglucosamine:α-6-D-Mannoside β-1,2-N-Acetylglucosaminyltransferase II

1995 • 60 citations

Diverse spatial expression patterns of UDP-GalNAc:polypeptide N-acetylgalactosaminyl-transferase family member mRNAs during mouse development

2000 • 60 citations

Exclusion of Three Candidate Genes as Determinants of Congenital Dyserythropoietic Anemia Type II (CDA-II)

1997 • 58 citations

Deficiency of dolichyl-P-Man:Man7GlcNAc2-PP-dolichyl mannosyltransferase causes congenital disorder of glycosylation type Ig

2002 • 58 citations

Knockout of mouse β1,4-galactosyltransferase-1 gene results in a dramatic shift of outer chain moieties of N-glycans from type 2 to type 1 chains in hepatic membrane and plasma glycoproteins

2001 • 57 citations

cDNA Cloning and Expression of Bovine UDP-N-Acetylglucosamine:α1,3-d-Mannoside β1,4-N-Acetylglucosaminyltransferase IV

1998 • 54 citations

Specificity of O-glycosylation by bovine colostrum UDP-GalNAc: polypeptide ?-N-acetylgalactosaminyltransferase using synthetic glycopeptide substrates

1996 • 54 citations

Well of darkness

1998 • 52 citations

Molecular Cloning and Characterization of the Mouse Ceramide Glucosyltransferase Gene

1998 • 51 citations

Macrothrombocytopenia with abnormal demarcation membranes in megakaryocytes and neutropenia with a complete lack of sialyl-Lewis-X antigen in leukocytes---a new syndrome?

2001 • 50 citations

A novel second isoenzyme of the human UDP-N-acetylglucosamine:alpha1,3-D-mannoside beta1,4-N-acetylglucosaminyltransferase family: cDNA cloning, expression, and chromosomal assignment.

1998 • 49 citations

Truncated, InactiveN-Acetylglucosaminyltransferase III (GlcNAc-TIII) Induces Neurological and Other Traits Absent in Mice That Lack GlcNAc-TIII

2002 • 48 citations

Progression of hepatic neoplasms is severely retarded in mice lacking the bisecting N-acetylglucosamine on N-glycans: evidence for a glycoprotein factor that facilitates hepatic tumor progression.

1998 • 46 citations

Molecular Cloning, Chromosomal Mapping, and Characterization of the Mouse UDP-Galactose:Ceramide Galactosyltransferase Gene

1996 • 45 citations

Cloning and chromosomal mapping of the mouse Mgat3 gene encoding N-acetylglucosaminyltransferase III

1995 • 45 citations

Transfection of a human gene that corrects the Lec1 glycosylation defect: evidence for transfer of the structural gene for N-acetylglucosaminyltransferase I.

1989 • 43 citations

Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family

2001 • 42 citations

Oligosaccharide Valency and Conformation in Determining Binding to the Asialoglycoprotein Receptor of Rat Hepatocytes

1993 • 40 citations

Complex asparagine-linked oligosaccharides in Mgat1-null embryos

1995 • 40 citations

cDNA cloning, genomic organization and chromosomal localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase-2

1998 • 37 citations

The gene for a novel glycosyltransferase is mutated in congenital muscular dystrophy MDC1C and limb girdle muscular dystrophy 2I

2002 • 36 citations

Ancient Origin of the Null Allele se 428 of the Human ABO-Secretor Locus (FUT2)

2000 • 35 citations

Complex N-glycans in Mgat1 null preimplantation embryos arise from maternal Mgat1 RNA

1997 • 35 citations

Identification of a Missense Mutation (G329A; Arg110→ Gln) in the Human FUT7 Gene

2001 • 35 citations

Differential Requirements for Core2 Glucosaminyltransferase for Endothelial L-Selectin Ligand Function In Vivo

2001 • 34 citations

Untitled

2001 • 33 citations

Essential role for complex N-glycans in forming an organized layer of bronchial epithelium.

1996 • 33 citations

Aberrant glycosylation of IgA from patients with IgA nephropathy

1996 • 31 citations

Purification and Characterization of UDP-GlcNAc: GlcNAcβ1–6(GlcNAcβ1–2)Manα1-R [GlcNAc to Man]-β1, 4-N-acetylglucosaminyltransferase VI from Hen Oviduct

2000 • 31 citations

Untitled

2001 • 30 citations

Heparan sulfate: growth control with a restricted sequence menu

2001 • 27 citations

Paroxysmal nocturnal hemoglobinuria: Insights from recent advances in molecular biology1

2001 • 26 citations

Impaired Galactosylation of Core 2 O-Glycans in Erythrocytes of β1,4-Galactosyltransferase Knockout Mice

1999 • 25 citations

Transdifferentiation as a basis for amphibian limb regeneration

1995 • 25 citations

N-Glycan processing and glycoprotein folding

2001 • 22 citations

T cell receptor‐mediated stimulation of mouse thymocytes induces up‐regulation of the GM2/GD2 synthase gene

1995 • 21 citations

A Murine Homologue of the Drosophila brainiac Gene Shows Homology to Glycosyltransferases and Is Required for Preimplantation Development of the Mouse

2001 • 20 citations

Developmental and hormonal regulation of UDP-GlcNAc:dolichol phosphate GlcNAc-1-P transferase in mouse mammary gland.

1994 • 18 citations

Murine Models of Paroxysmal Nocturnal Hemoglobinuria

2002 • 17 citations

Gain-of-function Chinese Hamster Ovary Mutants LEC18 and LEC14 Each Express a Novel N-Acetylglucosaminyltransferase Activity

1998 • 13 citations

Chromosome Mapping of the GD3 Synthase Gene (SIAT8) in Human and Mouse

1996 • 13 citations

Transferrin protein variant mimicking carbohydrate‐deficient glycoprotein syndrome in trisomy 7 mosaicism

2000 • 13 citations

Deficiency of UDP-galactose:N-acetylglucosamine β-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId

2002 • 13 citations

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1999 • 12 citations

Paroxysmal nocturnal hemoglobinuria: Insights from recent advances in molecular biology

2001 • 11 citations

A mutation in the human MPDU1 gene causes congenital disorder of glycosylation type If (CDG-If)

2001 • 9 citations

The murine <i>Ext1</i> gene shows a high level of sequence similarity with its human homologue and is part of a conserved linkage group on chromosome 15

1997 • 8 citations

Evaluating Macular Function

1999 • 7 citations

Molecular cloning and expression analysis of a mouse UDP-GlcNAc:Gal(beta1-4)Glc(NAc)-R beta1,3-N-acetylglucosaminyltransferase homologous to Drosophila melanogaster Brainiac and the beta1,3-galactosyltransferase family.

2000 • 5 citations

Instructions to Authors

1999 • 1 citations

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1999 • 1 citations

A Successful Regimen for Treatment of Helicobacter pylori Infection

1999 • 1 citations