Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode α1,4- N -acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis

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pEF-BOS, a powerful mammalian expression vector

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The Biochemistry of Glycoproteins and Proteoglycans

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Specificities of heparan sulphate proteoglycans in developmental processes

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Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

1998 • 505 citations

Heparan sulfate: a piece of information

1996 • 441 citations

The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate

2000 • 433 citations

The Putative Tumor Suppressors EXT1 and EXT2 Are Glycosyltransferases Required for the Biosynthesis of Heparan Sulfate

1998 • 425 citations

Disruption of Gastrulation and Heparan Sulfate Biosynthesis in EXT1-Deficient Mice

2000 • 408 citations

Recent advances in the study of the biosynthesis and functions of sulfated glycosaminoglycans

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Structure and Metabolism of Connective Tissue Proteoglycans

1980 • 381 citations

The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate

1998 • 377 citations

Structural Analysis of Glycosaminoglycans inDrosophila and Caenorhabditis elegans and Demonstration That tout-velu, a Drosophila Gene Related to EXT Tumor Suppressors, Affects Heparan Sulfate in Vivo

2000 • 287 citations

A single mutation affects both N-acetylglucosaminyltransferase and glucuronosyltransferase activities in a Chinese hamster ovary cell mutant defective in heparan sulfate biosynthesis.

1992 • 286 citations

The Elusive Functions of Proteoglycans

2000 • 258 citations

Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups.

1994 • 223 citations

Influence of core protein sequence on glycosaminoglycan assembly

1996 • 204 citations

The Tumor Suppressor EXT-like Gene EXTL2 Encodes an α1, 4-N-Acetylhexosaminyltransferase That TransfersN-Acetylgalactosamine and N-Acetylglucosamine to the Common Glycosaminoglycan-Protein Linkage Region

1999 • 201 citations

Hereditary multiple exostosis and chondrosarcoma: linkage to chromosome II and loss of heterozygosity for EXT-linked markers on chromosomes II and 8.

1995 • 194 citations

Structure/function studies of glycosyltransferases

1999 • 189 citations

Molecular Cloning and Expression of Glucuronyltransferase I Involved in the Biosynthesis of the Glycosaminoglycan-Protein Linkage Region of Proteoglycans

1998 • 171 citations

The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis

2000 • 165 citations

HEREDITARY MULTIPLE EXOSTOSIS.

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Structural Analysis of Glycosaminoglycans in Animals Bearing Mutations in sugarless, sulfateless, andtout-velu

2000 • 156 citations

Identification and localization of the gene for EXTL, a third member of the multiple exostoses gene family.

1997 • 147 citations

Amino acid determinants that drive heparan sulfate assembly in a proteoglycan.

1994 • 145 citations

Repetitive Ser-Gly Sequences Enhance Heparan Sulfate Assembly in Proteoglycans

1995 • 144 citations

Loss of heterozygosity in chondrosarcomas for markers linked to hereditary multiple exostoses loci on chromosomes 8 and 11.

1995 • 138 citations

Biosynthesis of heparan sulfate on beta-D-xylosides depends on aglycone structure.

1994 • 137 citations

Identification of a Third EXT-like Gene (EXTL3) Belonging to the EXT Gene Family

1998 • 129 citations

Demonstration of glycosaminoglycans in Caenorhabditis elegans

1999 • 106 citations

Identification and characterization of a novel member of the EXT gene family, EXTL2.

1998 • 92 citations

Biosynthesis of heparin/heparan sulfate. Identification of a 70-kDa protein catalyzing both the D-glucuronosyl- and the N-acetyl-D-glucosaminyltransferase reactions.

1993 • 88 citations

Location of the Glucuronosyltransferase Domain in the Heparan Sulfate Copolymerase EXT1 by Analysis of Chinese Hamster Ovary Cell Mutants

2000 • 88 citations

Mechanisms Underlying Preferential Assembly of Heparan Sulfate on Glypican-1

2001 • 84 citations

Identification and Characterization of a Novel Member of the EXT Gene Family, EXTL2

1997 • 82 citations

Association of EXT1 and EXT2, Hereditary Multiple Exostoses Gene Products, in Golgi Apparatus

2000 • 76 citations

Two N-acetylgalactosaminyltransferase are involved in the biosynthesis of chondroitin sulfate

1985 • 73 citations

EXT genes are differentially expressed in bone and cartilage during mouse embryogenesis

2000 • 68 citations

Two N-acetylglucosaminyltransferases catalyze the biosynthesis of heparan sulfate.

1994 • 63 citations

rib-2, a Caenorhabditis elegans Homolog of the Human Tumor Suppressor EXT Genes Encodes a Novel α1,4-N-Acetylglucosaminyltransferase Involved in the Biosynthetic Initiation and Elongation of Heparan Sulfate

2001 • 59 citations

Regulation of chondroitin sulfate biosynthesis by specific sulfation: acceptor specificity of serum β-GalNAc transferase revealed by structurally defined oligosaccharides

1997 • 59 citations

Structural studies on the oligosaccharides isolated from bovine kidney heparan sulphate and characterization of bacterial heparitinases used as substrates

1994 • 57 citations

Structure, Chromosomal Location, and Expression Profile of EXTR1 and EXTR2, New Members of the Multiple Exostoses Gene Family

1998 • 56 citations

Characterization of serum β-glucuronyltransferase involved in chondroitin sulfate biosynthesis

1997 • 44 citations

Structural studies on the tri- and tetrasaccharides isolated from porcine intestinal heparin and characterization of heparinase/heparitinases using them as substrates

1994 • 43 citations

Involvement of the core protein in the first β-N-acetylgalactosamine transfer to the glycosaminoglycan–protein linkage-region tetrasaccharide and in the subsequent polymerization: the critical determining step for chondroitin sulphate biosynthesis

1999 • 26 citations

Identification and characterization of a novel UDP-GalNAc:GlcAbeta-R alpha1,4-N-acetylgalactosaminyltransferase from a human sarcoma cell line

1999 • 26 citations

Partial purification and substrate specificity of heparan sulfate α-N-acetylglucosaminyltransferase I: synthesis, NMR spectroscopic characterization and in vitro assays of two aryl tetrasaccharides

1997 • 22 citations

EXTL3/EXTR1 alterations in colorectal cancer cell lines.

1999 • 14 citations

Refined physical mapping and genomic structure of the EXTL1 gene

1999 • 11 citations