Alpha-Mannosidase-II Deficiency Results in Dyserythropoiesis and Unveils an Alternate Pathway in Oligosaccharide Biosynthesis

Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane

1971 • 8,619 citations

ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES

1985 • 4,790 citations

The Red Cell Membrane

1976 • 592 citations

Biosynthetic Controls That Determine the Branching and Microheterogeneity of Protein-Bound Oligosaccharides

1986 • 510 citations

Structural determinants of concanavalin A specificity for oligosaccharides

1979 • 467 citations

A Spectroscopic Investigation of Swainsonine: An α-Mannosidase Inhibitor Isolated from Swainsona canescens

1979 • 416 citations

Mice lacking N-acetylglucosaminyltransferase I activity die at mid-gestation, revealing an essential role for complex or hybrid N-linked carbohydrates.

1994 • 395 citations

Inhibition of lysosomal α-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens

1980 • 365 citations

Blood group ABH and Ii antigens of human erythrocytes: chemistry, polymorphism, and their developmental change.

1981 • 344 citations

Complex asparagine-linked oligosaccharides are required for morphogenic events during post-implantation development.

1994 • 336 citations

Glycosidases of the asparagine-linked oligosaccharide processing pathway

1994 • 330 citations

alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates.

1982 • 294 citations

Anion Exchanger 1 (Band 3) Is Required to Prevent Erythrocyte Membrane Surface Loss but Not to Form the Membrane Skeleton

1996 • 278 citations

T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination.

1995 • 266 citations

Swainsonine: an inhibitor of glycoprotein processing.

1981 • 252 citations

Control of glycoprotein synthesis.

1983 • 237 citations

Control of glycoprotein synthesis. Processing of asparagine-linked oligosaccharides by one or more rat liver Golgi alpha-D-mannosidases dependent on the prior action of UDP-N-acetylglucosamine: alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase I.

1980 • 227 citations

Hereditary Erythroblastic Multinuclearity Associated with a Positive Acidified‐Serum Test: a Type of Congenital Dyserythropoietic Anaemia

1969 • 217 citations

A structural basis for four distinct elution profiles on concanavalin A – Sepharose affinity chromatography of glycopeptides

1979 • 203 citations

The ‘yellow brick road’ to branched complex N-glycans

1991 • 193 citations

Carbohydrate deficient glycoprotein syndrome type II: a deficiency in Golgi localised N-acetyl-glucosaminyltransferase II.

1994 • 190 citations

Cell surface modification by endo-beta-galactosidase. Change of blood group activities and release of oligosaccharides from glycoproteins and glycosphingolipids of human erythrocytes.

1979 • 187 citations

Structural determinants of Phaseolus vulgaris erythroagglutinating lectin for oligosaccharides.

1983 • 185 citations

Three types of blood group I specificity among monoclonal anti-I autoantibodies revealed by analogues of a branched erythrocyte glycolipid.

1979 • 183 citations

Mutations in the MGAT2 gene controlling complex N-glycan synthesis cause carbohydrate-deficient glycoprotein syndrome type II, an autosomal recessive disease with defective brain development.

1996 • 157 citations

Novel purification of the catalytic domain of Golgi alpha-mannosidase II. Characterization and comparison with the intact enzyme.

1991 • 155 citations

Mannose corrects altered N-glycosylation in carbohydrate-deficient glycoprotein syndrome fibroblasts.

1996 • 148 citations

Relationship of the terminal sequences to the length of poly-N-acetyllactosamine chains in asparagine-linked oligosaccharides from the mouse lymphoma cell line BW5147. Immobilized tomato lectin interacts with high affinity with glycopeptides containing long poly-N-acetyllactosamine chains.

1987 • 140 citations

Isolation, characterization, and expression of cDNAs encoding murine alpha-mannosidase II, a Golgi enzyme that controls conversion of high mannose to complex N-glycans.

1991 • 129 citations

Recent advances in gene mutagenesis by site-directed recombination.

1996 • 112 citations

Cloning, Expression, Purification, and Characterization of the Human Broad Specificity Lysosomal Acid α-Mannosidase

1996 • 112 citations

Incomplete synthesis of N-glycans in congenital dyserythropoietic anemia type II caused by a defect in the gene encoding alpha-mannosidase II.

1990 • 106 citations

Primary defect of congenital dyserythropoietic anemia type II. Failure in glycosylation of erythrocyte lactosaminoglycan proteins caused by lowered N-acetylglucosaminyltransferase II.

1987 • 105 citations

Isolation, characterization and inactivation of the mouse Mgat3 gene: the bisecting N-acetylglucosamine in asparagine-linked oligosaccharides appears dispensable for viability and reproduction

1997 • 102 citations

Mutant of Chinese hamster ovary cells with altered mannose 6-phosphate receptor activity is unable to synthesize mannosylphosphoryldolichol.

1982 • 100 citations

Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme.

1995 • 98 citations

Immobilized lectin columns: useful tools for the fractionation and structural analysis of oligosaccharides

1992 • 93 citations

The similar effects of swainsonine and locoweed on tissue glycosidases and oligosaccharides of the pig indicate that the alkaloid is the principal toxin responsible for the induction of locoism

1984 • 83 citations

Carbohydrate‐deficient Glycoprotein Syndrome Type II

1995 • 77 citations

Defect in glycosylation of erythrocyte membrane proteins in congenital dyserythropoietic anaemia type II (HEMPAS)

1984 • 65 citations

Substrate specificities of rat kidney lysosomal and cytosolic alpha-D-mannosidases and effects of swainsonine suggest a role of the cytosolic enzyme in glycoprotein catabolism.

1987 • 64 citations

Production of hybrid glycoproteins and accumulation of oligosaccharides in the brain of sheep and pigs administered swainsonine or locoweed

1988 • 57 citations

Purification and characterization of a novel broad‐specificity (α1 → 2, α1 → 3 and α1 → 6) mannosidase from rat liver

1991 • 57 citations

Decreased glycosylation of band 3 and band 4‐5 glycoproteins of erythrocyte membrane in congenital dyserythropoietic anaemia type II

1982 • 51 citations

The spectrum of incomplete N-linked oligosaccharides synthesized by endothelial cells in the presence of brefeldin A.

1992 • 50 citations

Red cell membrane protein anomalies in congenital dyserythropoietic anaemia, type II (HEMPAS)

1982 • 48 citations

8 Congenital dyserythropoietic anaemia type II (HEMPAS) and its molecular basis

1993 • 47 citations

Incompletely processed N‐glycans of serum glycoproteins in congenital dyserythropoietic anaemia type II (HEMPAS)

1992 • 45 citations

Topology of mannosidase II in rat liver Golgi membranes and release of the catalytic domain by selective proteolysis.

1986 • 43 citations

Defective glycosylation of erythrocyte membrane glycoconjugates in a variant of congenital dyserythropoietic anemia type II: association of low level of membrane-bound form of galactosyltransferase

1989 • 43 citations

Complex asparagine-linked oligosaccharides in Mgat1-null embryos

1995 • 40 citations

Subcellular distribution in rat liver of a novel broad‐specificity (α1 → 2, α1 → 3 and α1 → 6) mannosidase active on oligomannose glycans

1992 • 28 citations

Cloning, expression, purification, and characterization of the murine lysosomal acid α-mannosidase1The sequences reported in this paper have been deposited in the GenBank data base with accession number U87240.1

1997 • 25 citations

Ricin-resistant mutants of baby-hamster-kidney cells deficient in alpha-mannosidase-II-catalyzed processing of asparagine-linked oligosaccharides

1986 • 25 citations

Structural analysis of the N-linked oligosaccharides from murine glycophorin

1991 • 15 citations

[Congenital dyserythropoietic anemia type II (HEMPAS)].

1992 • 4 citations