Notch Ligands Are Substrates for ProteinO-Fucosyltransferase-1 and Fringe

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

Fringe is a glycosyltransferase that modifies Notch

2000 • 846 citations

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

1991 • 770 citations

Glycosyltransferase activity of Fringe modulates Notch–Delta interactions

2000 • 686 citations

Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila

1990 • 675 citations

A simple method for site-directed mutagenesis using the polymerase chain reaction

1989 • 607 citations

Structural Basis for FGF Receptor Dimerization and Activation

1999 • 597 citations

Fringe modulates Notch–ligand interactions

1997 • 578 citations

Characterization and use of theDrosophilametallothionein promoter in culturedDrosophila melanogastercells

1988 • 440 citations

The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate

1997 • 407 citations

Mutations in the human Delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis

2000 • 385 citations

Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2

2000 • 377 citations

Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing

1997 • 369 citations

Mammalian Notch1 Is Modified with Two Unusual Forms ofO-Linked Glycosylation Found on Epidermal Growth Factor-like Modules

2000 • 335 citations

Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation.

1996 • 316 citations

A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway

1997 • 301 citations

Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc

1997 • 261 citations

O-Linked fucose and other post-translational modifications unique to EGF modules

1993 • 257 citations

C-Mannosylation and O-Fucosylation of the Thrombospondin Type 1 Module

2001 • 245 citations

Modification of Epidermal Growth Factor-like Repeats withO-Fucose

2001 • 240 citations

Dorsal-Ventral Signaling in the Drosophila Eye

1998 • 228 citations

Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus

1987 • 217 citations

Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis

1997 • 207 citations

Dual Roles of Cripto as a Ligand and Coreceptor in the Nodal Signaling Pathway

2002 • 203 citations

Structural conservation of Notch receptors and ligands

1998 • 201 citations

The Notch signalling regulator Fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DxD

2000 • 199 citations

Subversion of the T/B Lineage Decision in the Thymus by Lunatic Fringe-Mediated Inhibition of Notch-1

2001 • 195 citations

Notch signalling pathway and human diseases

1998 • 190 citations

Fringe, Notch, and making developmental boundaries

1999 • 189 citations

The Drosophila gene Serrate encodes an EGF-like transmembrane protein with a complex expression pattern in embryos and wing discs

1991 • 179 citations

Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila

1998 • 177 citations

Jagged1 mutations in patients ascertained with isolated congenital heart defects

1999 • 158 citations

Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila

1997 • 156 citations

Fringe modulation of Jagged1-induced Notch signaling requires the action of β4galactosyltransferase-1

2001 • 135 citations

Tissue plasminogen activator has an O-linked fucose attached to threonine-61 in the epidermal growth factor domain

1991 • 134 citations

Intracellular Cell-Autonomous Association of Notch and Its Ligands: A Novel Mechanism of Notch Signal Modification

2002 • 131 citations

Human plasma and recombinant factor VII. Characterization of O-glycosylations at serine residues 52 and 60 and effects of site-directed mutagenesis of serine 52 to alanine

1991 • 128 citations

Human factor IX has a tetrasaccharide O-glycosidically linked to serine 61 through the fucose residue.

1992 • 125 citations

The Abruptex domain of Notch regulates negative interactions between Notch, its ligands and Fringe

2000 • 122 citations

Manic Fringe and Lunatic Fringe Modify Different Sites of the Notch2 Extracellular Region, Resulting in Different Signaling Modulation

2001 • 117 citations

Aspartate Mutations in Presenilin and γ‐Secretase Inhibitors Both Impair Notch1 Proteolysis and Nuclear Translocation with Relative Preservation of Notch1 Signaling

2000 • 116 citations

Purification and Characterization of a GDP-fucose:Polypeptide Fucosyltransferase from Chinese Hamster Ovary Cells

1998 • 106 citations

New animal lectin structures

1999 • 96 citations

Isolation and structural determination of three peptides from the insect Locusta migratoria

1992 • 92 citations

Fucosylation of Cripto Is Required for Its Ability to Facilitate Nodal Signaling

2001 • 89 citations

O-linked fucose is present in the first epidermal growth factor domain of factor XII but not protein C.

1992 • 84 citations

Second-site modifiers of the split mutation of Notch define genes involved in neurogenesis in Drosophila melanogaster

1990 • 80 citations

Modulators of Notch signaling

1998 • 79 citations

Carbohydrate composition and presence of a fucose-protein linkage in recombinant human pro-urokinase

1990 • 75 citations

Fringe forms a complex with Notch

2000 • 75 citations

The O-linked fucose glycosylation pathway: identification and characterization of a uridine diphosphoglucose: fucose-beta1,3- glucosyltransferase activity from Chinese hamster ovary cells

1999 • 53 citations

Solution Structure of PMP-C: A New Fold in the Group of Small Serine Proteinase Inhibitors

1996 • 46 citations

Jagged1 (JAG1) mutation detection in an Australian Alagille syndrome population

2000 • 34 citations

O-Linked L-Fucose Is Present in Desmodus rotundus Salivary Plasminogen Activator

1996 • 31 citations