Perforin-Deficient CD8+ T Cells: In Vivo Priming and Antigen-Specific Immunity AgainstListeria monocytogenes

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

CELLULAR RESISTANCE TO INFECTION

1962 • 1,422 citations

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes

1986 • 1,282 citations

Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes.

1989 • 1,268 citations

Intracellular Inactivation of the Hepatitis B Virus by Cytotoxic T Lymphocytes

1996 • 1,085 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING

1998 • 1,017 citations

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

1998 • 989 citations

Regulation of Immunity to Parasites by T Cells and T Cell-Derived Cytokines

1992 • 843 citations

IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement.

1980 • 835 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

Massive Expansion of Antigen-Specific CD8+ T Cells during an Acute Virus Infection

1998 • 794 citations

ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX

1996 • 613 citations

Actin polymerization is induced by Arp 2/3 protein complex at the surface of Listeria monocytogenes

1997 • 598 citations

A solid-phase immunoenzymatic technique for the enumeration of specific antibody-secreting cells

1983 • 561 citations

Coordinate Regulation of Complex T Cell Populations Responding to Bacterial Infection

1998 • 535 citations

Interaction of Human Arp2/3 Complex and the Listeria monocytogenes ActA Protein in Actin Filament Nucleation

1998 • 500 citations

CD8+ T cells clear influenza virus by perforin or Fas-dependent processes.

1997 • 493 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

Specific immunity to listeria monocytogenes in the absence of IFNγ

1995 • 432 citations

Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice.

1994 • 411 citations

Adoptive transfer of immunity to Listeria monocytogenes. The influence of in vitro stimulation on lymphocyte subset requirements.

1987 • 387 citations

Strategies of Anti‐Cytokine Monoclonal Antibody Development: Immunoassay of IL‐10 and IL‐5 in Clinical Samples

1992 • 384 citations

Quantification of antigen specific CD8+ T cells using an ELISPOT assay

1995 • 367 citations

Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

1994 • 307 citations

CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo.

1992 • 260 citations

Studies with MHC-deficient knock-out mice reveal impact of both MHC I- and MHC II-dependent T cell responses on listeria monocytogenes infection

1995 • 244 citations

CD8+ T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity

1994 • 229 citations

Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity.

1995 • 229 citations

Compartmentalization of Bacterial Antigens: Differential Effects on Priming of CD8 T Cells and Protective Immunity

1998 • 228 citations

A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity.

1994 • 224 citations

Studies with MHC-deficient knock-out mice reveal impact of both MHC I- and MHC II-dependent T cell responses on Listeria monocytogenes infection.

1994 • 201 citations

Perforin, Fas ligand, and tumor necrosis factor are the major cytotoxic molecules used by lymphokine-activated killer cells.

1996 • 187 citations

Immunodominant and subdominant CTL responses to Listeria monocytogenes infection.

1997 • 146 citations

Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases

1998 • 144 citations

Prospects for adoptive T cell therapy

1997 • 139 citations

Actin filament nucleation by the bacterial pathogen, Listeria monocytogenes.

1990 • 134 citations

Role of T Cell Subsets in Immunity against Intracellular Bacteria: Experimental Infections of Knock-Out Mice with Listeria monocytogenes and Mycobacterium bovis BCG

1994 • 127 citations

MHC class I antigen processing of Listeria monocytogenes proteins: implications for dominant and subdominant CTL responses

1997 • 112 citations

CD8 T lymphocytes specific for the secreted p60 antigen protect against Listeria monocytogenes infection.

1995 • 105 citations

Listeria monocytogenes infection in beta 2 microglobulin-deficient mice

1993 • 100 citations

ChronicListeriaInfection in SCID Mice: Requirements for the Carrier State and the Dual Role of T Cells in Transferring Protection or Suppression

1998 • 93 citations

Perforin-deficient CD8+ T cells provide immunity to Listeria monocytogenes by a mechanism that is independent of CD95 and IFN-gamma but requires TNF-alpha.

1998 • 93 citations

Perforin and Fas killing by CD8+ T cells limits their cytokine synthesis and proliferation.

1996 • 90 citations

Primary and secondary immune responses to Listeria monocytogenes

1996 • 88 citations

Acquired resistance to Listeria monocytogenes is mediated by Lyt-2+ T cells independently of the influx of monocytes into granulomatous lesions.

1989 • 86 citations

Perforin-Deficient CD8+ T Cells Provide Immunity to Listeria monocytogenes by a Mechanism That Is Independent of CD95 and IFN-γ but Requires TNF-α

1998 • 83 citations

Antiviral immunity

1997 • 69 citations

Fas (CD95)-Dependent Cell-Mediated Immunity to Listeria monocytogenes

1998 • 60 citations

CD8 T-cell recognition of macrophages and hepatocytes results in immunity to Listeria monocytogenes

1996 • 52 citations

The role of granzyme B cluster proteases in cell-mediated cytotoxicity

1997 • 52 citations

Cytotoxic T Cell Effector and Memory Function in Viral Immunity

1996 • 49 citations

Immunological control of murine gammaherpesvirus infection is independent of perforin.

1997 • 39 citations

Recombinant Listeria monocytogenes as a live vaccine vehicle and a probe for studying cell‐mediated immunity

1997 • 38 citations

Antigen Specificity of CD4 T Cell Response in the Central Nervous System of Mice Infected with Mouse Hepatitis Virus

1997 • 31 citations

Granzyme B-Induced Apoptosis

1996 • 24 citations