Cytotoxic T Cell Effector and Memory Function in Viral Immunity

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

Impaired immune and acute-phase responses in interleukin-6-deficient mice

1994 • 1,776 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells

1990 • 997 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytes choriomeningitis

1974 • 832 citations

Cytotoxic T-cell memory without antigen

1994 • 669 citations

Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV

1994 • 611 citations

Virus-specific CD8+ T-cell memory determined by clonal burst size

1994 • 525 citations

Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation.

1987 • 505 citations

Immune Responses in Interleukin-2-Deficient Mice

1993 • 476 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific.

1984 • 439 citations

Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice.

1994 • 411 citations

Heterosubtypic immunity to influenza type A virus in mice. Effector mechanisms and their longevity.

1994 • 400 citations

Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity.

1994 • 386 citations

Specificity of Virus‐Immune Effector T Cells for H‐2K or H‐2D Compatible Interactions: Implications for H‐Antigen Diversity

1976 • 385 citations

Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge.

1992 • 381 citations

Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells.

1991 • 372 citations

Cellular events in the lymph node and lung of mice with influenza. Consequences of depleting CD4+ T cells.

1990 • 340 citations

Protection against lethal Sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with a free synthetic peptide.

1991 • 334 citations

The Binding and Lysis of Target Cells by Cytotoxic Lymphocytes: Molecular and Cellular Aspects

1994 • 312 citations

A Central Role of Perforin in Cytolysis?

1991 • 288 citations

T and B memory cells

1994 • 285 citations

Influenza virus-specific CD4+ T helper type 2 T lymphocytes do not promote recovery from experimental virus infection.

1994 • 283 citations

Immunological Memory

1993 • 250 citations

Response to influenza infection in mice with a targeted disruption in the interferon gamma gene.

1993 • 247 citations

Delayed clearance of Sendai virus in mice lacking class I MHC-restricted CD8+ T cells.

1992 • 237 citations

Altering Genes in Animals by Gene Targeting

1992 • 224 citations

Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex

1975 • 217 citations

A case for cytokines as effector molecules in the resolution of virus infection

1993 • 216 citations

Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression.

1991 • 201 citations

Effect of cloned interferon‐γ on expression of H‐2 and Ia antigens on cell lines of hemopoietic, lymphoid, epithelial, fibroblastic and neuronal origin

1984 • 192 citations

The long-term maintenance of cytotoxic T cell memory does not require persistence of antigen.

1994 • 190 citations

Dissection of an inflammatory process induced by CD8+ T cells

1990 • 187 citations

Cytokines in the generation of immune responses to, and resolution of, virus infection

1994 • 185 citations

Mucosal immunity to infection with implications for vaccine development

1994 • 176 citations

Mice can recover from pulmonary influenza virus infection in the absence of class I-restricted cytotoxic T cells.

1992 • 174 citations

H-2 compatibility requirement for virus-specific T cell-mediated effector functions in vivo. I. Specificity of T cells conferring antiviral protection against lymphocytic choriomeningitis virus is associated with H-2K and H-2D.

1976 • 173 citations

LCMV-Specific, Class II-Restricted Cytotoxic T Cells in β2-Microglobulin-Deficient Mice

1992 • 164 citations

Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia.

1993 • 150 citations

Prominent usage of V beta 8.3 T cells in the H-2Db-restricted response to an influenza A virus nucleoprotein epitope.

1993 • 150 citations

Functionally conformed free class I heavy chains exist on the surface of beta 2 microglobulin negative cells.

1992 • 146 citations

Skin graft rejection by beta 2-microglobulin-deficient mice.

1992 • 142 citations

Induction or prevention of immunopathological disease by cloned cytotoxic T cell lines specific for lymphocytic choriomeningitis virus

1986 • 138 citations

Concurrent production of interleukin-2, interleukin-10, and gamma interferon in the regional lymph nodes of mice with influenza pneumonia

1994 • 134 citations

Inefficient positive selection of T cells directed by haematopoietic cells

1992 • 132 citations

Temporal loss of the activated L-selectin-low phenotype for virus-specific CD8+ memory T cells.

1995 • 130 citations

Molecularly engineered vaccine which expresses an immunodominant T-cell epitope induces cytotoxic T lymphocytes that confer protection from lethal virus infection

1989 • 127 citations

Influenza virus RNA in the lung and lymphoid tissue of immunologically intact and CD4-depleted mice

1991 • 115 citations

MHC Class I-Deficient Mice

1993 • 112 citations

Cell-mediated cytotoxicity

1993 • 108 citations

Conservation of T cell receptor usage by HLA B27‐restricted influenza‐specific cytotoxic T lymphocytes suggests a general pattern for antigen‐specific major histocompatibility complex class I‐restricted responses

1993 • 104 citations

H-2 Compatibility Requirement for Virus-Specific T Cell-Mediated Effector Functions in Vivo

1976 • 99 citations

Heterogeneity of the cytotoxic response of thymus-derived lymphocytes after immunization with influenza viruses.

1977 • 98 citations

CD8+ T-cell memory to viruses

1994 • 96 citations

The MHC class l-restricted T cell response to Sendai virus infection in C57BL/6 mice: a single immunodominant epitope elicits an extremely diverse repertoire of T cells

1994 • 95 citations

In vivo expression of perforin by CD8+ lymphocytes during an acute viral infection.

1989 • 93 citations

Partitioning of responder CD8+ T cells in lymph node and lung of mice with Sendai virus pneumonia by LECAM-1 and CD45RB phenotype.

1993 • 93 citations

Respiratory virus infection of mice provokes a permanent humoral immune response

1994 • 90 citations

Cytokine-specific ELISPOT assay single cell analysis of IL-2, IL-4 and IL-6 producing cells

1993 • 90 citations

Frequency analysis of lymphokine-secreting CD4+ and CD8+ T cells activated in a graft-versus-host reaction.

1990 • 90 citations

Antiviral immune responses of lymphocytic choriomeningitis virus-infected mice lacking CD8+ T lymphocytes because of disruption of the beta 2-microglobulin gene

1993 • 88 citations

Specificity and Development of Cytotoxic Thymus-Derived Lymphocytes in Lymphocytic Choriomeningitis

1974 • 87 citations

Administration of anti-IFN-gamma antibody to beta 2-microglobulin-deficient mice delays influenza virus clearance but does not switch the response to a T helper cell 2 phenotype.

1994 • 86 citations

Capacity of Sensitized Thymus-Derived Lymphocytes to Induce Fatal Lymphocytic Choriomeningitis Is Restricted by the H-2 Gene Complex

1975 • 85 citations

Primary pulmonary cytotoxic T lymphocytes induced by immunization with a vaccinia virus recombinant expressing influenza A virus nucleoprotein peptide do not protect mice against challenge

1994 • 83 citations

Cell-mediated immune responses to influenza virus antigens expressed by vaccinia virus recombinants

1986 • 83 citations

Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus

1989 • 81 citations

Phenotypic analysis of the inflammatory exudate in murine lymphocytic choriomeningitis.

1987 • 74 citations

Inflammatory Process in Murine Lymphocytic Choriomeningitis Is Maximal in H-2K or H-2D Compatible Interactions

1976 • 69 citations

Virus-lymphocyte interaction: T cells of the helper subset are infected with lymphocytic choriomeningitis virus during persistent infection in vivo

1987 • 68 citations

Phenotypic and functional analysis of the cellular response in regional lymphoid tissue during an acute virus infection.

1989 • 65 citations

Virus-specific memory T cells are Pgp-1+ and can be selectively activated with phorbol ester and calcium lonophore

1988 • 60 citations

Protection against lethal lymphocytic choriomeningitis virus (LCMV) infection by immunization of mice with an influenza virus containing an LCMV epitope recognized by cytotoxic T lymphocytes

1994 • 60 citations

Lymphocytic choriomeningitis virus induces a chronic wasting disease in mice lacking class I major histocompatibility complex glycoproteins

1993 • 58 citations

Vaccinia virus-specific CD8+ cytotoxic T lymphocytes in humans

1993 • 58 citations

Cytokine profiles of bronchoalveolar lavage cells from mice with influenza pneumonia: consequences of CD4+ and CD8+ T cell depletion.

1993 • 57 citations

Characterization of virus‐specific cytotoxic T cell clones from allogeneic bone marrow chimeras

1987 • 56 citations

Diversity of T-cell receptors in virus-specific cytotoxic T lymphocytes recognizing three distinct viral epitopes restricted by a single major histocompatibility complex molecule

1992 • 49 citations

Location and character of the cellular enzyme that cleaves the hemagglutinin of a virulent avian influenza virus

1992 • 47 citations

Clearance of Sendai virus by CD8⁺ T cells requires direct targeting to virus‐infected epithelium

1995 • 45 citations

Virus infections in mice with targeted gene disruptions

1993 • 43 citations

Diversity in the biological properties of anti‐influenza cytotoxic T cell clones

1983 • 42 citations

Development and antigen specificity of CD8+ cytotoxic T lymphocytes in beta 2-microglobulin-negative, MHC class I-deficient mice in response to immunization with tumor cells.

1994 • 41 citations

Immune exhaustion: driving virus-specific CD8+ T cells to death

1993 • 40 citations

Expression of Pgp‐1 (or Ly24) by subpopulations of mouse thymocytes and activated peripheral T lymphocytes

1987 • 38 citations

Immune surveillance against Epstein-Barr virus.

1992 • 37 citations

Regulation of T cell production in T cell receptor transgenic mice

1993 • 36 citations

Tracking HIV during disease progression

1994 • 36 citations

Recombinant Vaccinia Viruses and the Development of Immunization Strategies Using Influenza Virus

1989 • 28 citations

Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. VI. Migration and activity in vivo in acute and persistent infection.

1986 • 27 citations

EFFECTS OF THYMUS‐INDEPENDENT (B) CELLS AND THE H‐2 GENE COMPLEX ON ANTIVIRAL FUNCTION OF IMMUNE THYMUS‐DERIVED (T) CELLS

1975 • 27 citations

Divergence between cytotoxic effector function and tumor necrosis factor alpha production for inflammatory CD4+ T cells from mice with Sendai virus pneumonia

1993 • 26 citations

Mice Lacking CD8+ T Cells Develop Greater Numbers of IgA-Producing Cells in Response to a Respiratory Virus Infection

1994 • 25 citations

IFN-gamma, TNF, and IL-6 production by vaccinia virus immune spleen cells. An in vitro study.

1994 • 25 citations

Recognition of Intracellular Measles Virus Antigens by HLA Class II Restricted Measles Virus‐Specific Cytotoxic T Lymphocytes

1988 • 24 citations

Cytotoxic T Lymphocytes in Human Immunodeficiency Virus Infection: Regulator Genes

1994 • 18 citations

Cell-surface expression of H-2Db requires N-linked glycans

1987 • 18 citations

Virus-specific CD8+ T-cell responses in mice transgenic for a T-cell receptor beta chain selected at random

1994 • 17 citations

Limiting the available T cell receptor repertoire modifies acute lymphocytic choriomeningitis virus-induced immunopathology

1994 • 12 citations

Limiting dilution cultures reveal latent influenza virus-specific helper T cells in virus-primed mice.

1984 • 12 citations

T-Cell Receptor Heterogeneity among Epstein-Barr Virus-Stimulated T-Cell Populations

1993 • 11 citations

Initiation of Persistent Lymphocytic Choriomeningitis Infection in Adult Mice

1971 • 11 citations

Cytotoxic T Cells in Paramyxovirus Infection of Humans

1994 • 8 citations

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