Recombinant Listeria monocytogenes as a live vaccine vehicle and a probe for studying cell‐mediated immunity

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

CELLULAR RESISTANCE TO INFECTION

1962 • 1,422 citations

Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes.

1989 • 1,268 citations

Listeria monocytogenes, a food-borne pathogen.

1991 • 1,239 citations

Immunity to Intracellular Bacteria

1993 • 1,085 citations

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

1994 • 1,066 citations

A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells

1983 • 1,054 citations

A Phagosome-to-Cytosol Pathway for Exogenous Antigens Presented on MHC Class I Molecules

1995 • 882 citations

Role of hemolysin for the intracellular growth of Listeria monocytogenes.

1988 • 881 citations

L. monocytogenes-induced actin assembly requires the actA gene product, a surface protein

1992 • 790 citations

Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.

1984 • 782 citations

The Adjuvant Effect of Interleukin-12 in a Vaccine Against Leishmania major

1994 • 687 citations

Cytotoxic T-cell memory without antigen

1994 • 669 citations

Phagocytic processing of bacterial antigens for class I MHC presentation to T cells

1993 • 625 citations

The Virology and Immunobiology of Lymphocytic Choriomeningitis Virus Infection

1980 • 554 citations

The N-end rule

1992 • 464 citations

Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes

1991 • 425 citations

Nucleotide sequence of the lecithinase operon of Listeria monocytogenes and possible role of lecithinase in cell-to-cell spread

1992 • 393 citations

REQUIREMENT OF THYMUS (T) LYMPHOCYTES FOR RESISTANCE TO LISTERIOSIS

1972 • 352 citations

Defective presentation to class I-restricted cytotoxic T lymphocytes in vaccinia-infected cells is overcome by enhanced degradation of antigen.

1988 • 331 citations

THE RELATIVE IMPORTANCE OF BLOOD MONOCYTES AND FIXED MACROPHAGES TO THE EXPRESSION OF CELL-MEDIATED IMMUNITY TO INFECTION

1970 • 326 citations

Lipoteichoic acid preparations of gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway

1996 • 325 citations

Natural Immunity: A T‐Cell‐Independent Pathway of Macrophage Activation, Defined in the scid Mouse

1991 • 321 citations

A role for the ubiquitin-dependent proteolytic pathway in MHC class l-restricted antigen presentation

1993 • 317 citations

Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo

1984 • 296 citations

MHC Class I–Restricted CTL Responses to Exogenous Antigens

1996 • 265 citations

CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo.

1992 • 260 citations

A recombinant Listeria monocytogenes vaccine expressing a model tumour antigen protects mice against lethal tumour cell challenge and causes regression of established tumours

1995 • 237 citations

The expression of virulence genes in Listeria monocytogenes is thermoregulated

1992 • 236 citations

Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity.

1995 • 229 citations

Superior efficacy of secreted over somatic antigen display in recombinant Salmonella vaccine induced protection against listeriosis.

1996 • 219 citations

T4+ T helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T-cell and antibody responses

1988 • 205 citations

Neutrophil-mediated dissolution of infected host cells as a defense strategy against a facultative intracellular bacterium.

1991 • 200 citations

Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection.

1996 • 189 citations

Human immunodeficiency virus infection and invasive cervical carcinoma

1993 • 186 citations

Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus

1993 • 185 citations

Mechanism of recovery from acute virus infection: treatment of lymphocytic choriomeningitis virus-infected mice with monoclonal antibodies reveals that Lyt-2+ T lymphocytes mediate clearance of virus and regulate the antiviral antibody response

1987 • 185 citations

Fate of Listeria monocytogenes in murine macrophages: evidence for simultaneous killing and survival of intracellular bacteria

1994 • 180 citations

The unrelated surface proteins ActA of Listeria monocytogenes and lcsA of Shigella flexneri are sufficient to confer actin‐based motility on Listeria innocua and Escherichia coli respectively

1995 • 176 citations

Induction of phagocytic behaviour in human epithelial cells by Escherichia coli cytotoxic necrotizing factor type1

1993 • 175 citations

Detection of individual mouse splenic T cells producing IFN-γ and IL-5 using the enzyme-linked immunospot (ELISPOT) assay

1990 • 166 citations

Killing of Listeria monocytogenes by Inflammatory Neutrophils and Mononuclear Phagocytes From Immune and Nonimmune Mice

1984 • 162 citations

Molecular and Genetic Determinants of the Listeria monocytogenes Infectious Process

1994 • 162 citations

Direct sequence identification and kinetic analysis of an MHC class I-restricted Listeria monocytogenes CTL epitope.

1994 • 161 citations

The virulence gene cluster of Listeria monocytogenes is also present in Listeria ivanovii, an animal pathogen, and Listeria seeligeri, a nonpathogenic species

1994 • 152 citations

Major histocompatibility complex – dependent T cell epitopes of lymphocytic choriomeningitis virus nucleoprotein and their protective capacity against viral disease

1989 • 140 citations

Molecular analyses of a five-amino-acid cytotoxic T-lymphocyte (CTL) epitope: an immunodominant region which induces nonreciprocal CTL cross-reactivity

1989 • 138 citations

Delivery of a viral antigen to the class I processing and presentation pathway by Listeria monocytogenes.

1994 • 132 citations

Induction of a cellular immune response to a foreign antigen by a recombinant Listeria monocytogenes vaccine.

1992 • 116 citations

CD8 T lymphocytes specific for the secreted p60 antigen protect against Listeria monocytogenes infection.

1995 • 105 citations

Regression of established tumors in mice mediated by the oral administration of a recombinant Listeria monocytogenes vaccine.

1995 • 94 citations

Immunization with nonstructural proteins E1 and E2 of cottontail rabbit papillomavirus stimulates regression of virus-induced papillomas

1995 • 93 citations

Induction of cell-mediated immune responses to human immunodeficiency virus type 1 Gag protein by using Listeria monocytogenes as a live vaccine vector.

1995 • 91 citations

Secondary response to Listeria infection requires IFN-gamma but is partially independent of IL-12.

1995 • 90 citations

Innate immunity to a facultative intracellular bacterial pathogen

1992 • 89 citations

Molecular basis of organ-specific selection of viral variants during chronic infection

1991 • 83 citations

Pathogenicity and immunogenicity of Listeria monocytogenes small-plaque mutants defective for intracellular growth and cell-to-cell spread

1992 • 82 citations

Listeriolysin O is a target of the immune response to Listeria monocytogenes.

1992 • 79 citations

Immune therapy of a persistent and disseminated viral infection

1987 • 77 citations

Effective clearance of a persistent viral infection requires cooperation between virus-specific Lyt2+ T cells and nonspecific bone marrow-derived cells

1987 • 76 citations

Attenuated Listeria monocytogenes as a live vector for induction of CD8⁺ T cells in vivo: a study with the nucleoprotein of the lymphocytic choriomeningitis virus

1995 • 76 citations

Identification of a CD4+ T cell-stimulating antigen of pathogenic bacteria by expression cloning.

1995 • 69 citations

Induction of cytokines in phagocytic mammalian cells infected with virulent and avirulent Listeria strains

1994 • 67 citations

Transcriptional activation of the Listeria monocytogenes hemolysin gene in Bacillus subtilis

1992 • 66 citations

Resolution of Primary Murine Listeriosis and Acquired Resistance to Lethal Secondary Infection Can Be Mediated Predominantly by Thy-1+ CD4- CD8- Cells

1991 • 66 citations

Cottontail rabbit papillomavirus L1 protein-based vaccines: protection is achieved only with a full-length, nondenatured product

1993 • 65 citations

Determination of virulence of different strains of Listeria monocytogenes and Listeria innocua by oral inoculation of pregnant mice

1992 • 56 citations

Morphometric analysis and identification of infiltrating leucocytes in regressing and progressing shope rabbit papillomas

1991 • 55 citations

Hyperexpression of listeriolysin in the nonpathogenic species Listeria innocua and high yield purification

1995 • 50 citations

Antiviral cytotoxic T-cell memory by vaccination with recombinant Listeria monocytogenes

1996 • 49 citations

Immunological memory against viruses.

1992 • 46 citations

Recombinant Listeria monocytogenes cancer vaccines

1996 • 45 citations

Animal Models of Human-Papillomavirus-Associated Oncogenesis

1994 • 45 citations

The Role of Cytokines in Experimental Listeriosis

1993 • 44 citations

Antitumor Immunity in the Shope Papilloma-Carcinoma Complex of Rabbits. Ill. Response to Reinfection With Viral Nucleic Acid<xref ref-type="fn" rid="FN1">2</xref>

1966 • 39 citations

IL 12 in acute viral infectious disease

1995 • 31 citations

Papillomaviruses and Carcinogenic Progression I

1987 • 30 citations

Antigen-specific T-cell responses during primary and secondary Listeria monocytogenes infection

1994 • 29 citations

Phosphatidylinositol-specific phospholipase C from Listeria monocytogenes contributes to intracellular survival and growth of Listeria innocua

1994 • 29 citations

Intra- and Extracellular Control Mechanisms of Human Papillomavirus Infection

1994 • 28 citations

Lysis of infected cells in vivo by antiviral cytolytic T cells demonstrated by release of cell internal viral proteins

1993 • 19 citations