Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice

1989 • 692 citations

Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis.

1993 • 454 citations

Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors.

1989 • 385 citations

Immunobiology and Pathogenesis of Hepatocellular Injury in Hepatitis B Virus Transgenic Mice

1990 • 363 citations

Patterns of cytokine gene expression by CD4+ T cells from young and old mice.

1993 • 357 citations

Anti-IL-6 monoclonal antibodies protect against lethal Escherichia coli infection and lethal tumor necrosis factor-alpha challenge in mice.

1990 • 343 citations

HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection.

1993 • 333 citations

Monoclonal antibodies to murine gamma-interferon which differentially modulate macrophage activation and antiviral activity.

1985 • 286 citations

Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice

1986 • 264 citations

Class I-restricted cytotoxic T lymphocytes are directly cytopathic for their target cells in vivo.

1994 • 199 citations

Tumor necrosis factor alpha negatively regulates hepatitis B virus gene expression in transgenic mice

1992 • 145 citations

Interleukin-2 and alpha/beta interferon down-regulate hepatitis B virus gene expression in vivo by tumor necrosis factor-dependent and -independent pathways

1994 • 140 citations

HBsAg retention sensitizes the hepatocyte to injury by physiological concentrations of interferon-γ

1992 • 137 citations

Molecular neurobiology; a practical approach

1992 • 92 citations

Interleukin-2 downregulates hepatitis B virus gene expression in transgenic mice by a posttranscriptional mechanism

1993 • 75 citations

Monoclonal antibodies to murine IL-1 alpha. Production, characterization, and inhibition of membrane-associated IL-1 activity.

1988 • 55 citations

Generation of monoclonal antibodies to murine IL-1 beta and demonstration of IL-1 in vivo.

1991 • 44 citations

Molecular neurobiology: A practical approach

1992 • 19 citations