Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Free Radicals in the Physiological Control of Cell Function

2002 • 9,561 citations

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

2001 • 4,537 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

The Free Radical Theory of Aging Matures

1998 • 3,846 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

2001 • 3,215 citations

STATs: transcriptional control and biological impact

2002 • 3,050 citations

Nitric oxide synthases: Roles, tolls, and controls

1994 • 2,945 citations

Points of control in inflammation

2002 • 2,599 citations

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

2001 • 2,550 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF

2001 • 2,481 citations

Physiological functions of thioredoxin and thioredoxin reductase

2000 • 2,440 citations

Calcium oscillations increase the efficiency and specificity of gene expression

1998 • 1,870 citations

PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light

1999 • 1,622 citations

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

2002 • 1,512 citations

THE AMP-ACTIVATED/SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell?

1998 • 1,446 citations

Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens

2000 • 1,429 citations

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

1977 • 1,422 citations

Protein S-nitrosylation: a physiological signal for neuronal nitric oxide

2001 • 1,391 citations

Nitrosylation

2001 • 1,229 citations

Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide

1997 • 1,208 citations

Oxygen radicals and signaling

1998 • 1,163 citations

Activation of the OxyR Transcription Factor by Reversible Disulfide Bond Formation

1998 • 1,162 citations

HIF-1 and mechanisms of hypoxia sensing

2001 • 1,131 citations

REDOX REGULATION OF CELLULAR ACTIVATION

1997 • 1,121 citations

REGULATION OF GENE EXPRESSION BY REACTIVE OXYGEN

1999 • 1,102 citations

Reversible Oxidation and Inactivation of Protein Tyrosine Phosphatases In Vivo

2002 • 1,020 citations

Regulation of Clock and NPAS2 DNA Binding by the Redox State of NAD Cofactors

2001 • 1,013 citations

S-Nitrosylation of Matrix Metalloproteinases: Signaling Pathway to Neuronal Cell Death

2002 • 943 citations

Mammalian TOR: A Homeostatic ATP Sensor

2001 • 936 citations

A Thiol Peroxidase Is an H2O2 Receptor and Redox-Transducer in Gene Activation

2002 • 875 citations

Nonredundant Roles of the mPer1 and mPer2 Genes in the Mammalian Circadian Clock

2001 • 873 citations

Soluble Adenylyl Cyclase as an Evolutionarily Conserved Bicarbonate Sensor

2000 • 831 citations

Does nitric oxide modulate mitochondrial energy generation and apoptosis?

2002 • 779 citations

Hydrogen peroxide as second messenger in lymphocyte activation

2002 • 760 citations

Studies on the Mechanism of Hormone Action

1972 • 682 citations

Peroxynitrite reductase activity of bacterial peroxiredoxins

2000 • 673 citations

Hydrogen Peroxide: A Key Messenger That Modulates Protein Phosphorylation Through Cysteine Oxidation

2000 • 638 citations

Regulation of Corepressor Function by Nuclear NADH

2002 • 595 citations

The harlequin mouse mutation downregulates apoptosis-inducing factor

2002 • 595 citations

Gene regulation mediated by calcium signals in T lymphocytes

2001 • 572 citations

Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation

2001 • 531 citations

Nitric oxide and the regulation of gene expression

2001 • 529 citations

Insulin-stimulated Hydrogen Peroxide Reversibly Inhibits Protein-tyrosine Phosphatase 1B in Vivo and Enhances the Early Insulin Action Cascade

2001 • 511 citations

A β ₂ Adrenergic Receptor Signaling Complex Assembled with the Ca ²⁺ Channel Ca _v 1.2

2001 • 509 citations

Calcium signalling—an overview

2001 • 505 citations

Targeting of Cyclic AMP Degradation to β ₂ -Adrenergic Receptors by β-Arrestins

2002 • 496 citations

OxyR

2002 • 459 citations

Signaling Networks

2000 • 458 citations

Reprogramming of the Macrophage Transcriptome in Response to Interferon-γ and Mycobacterium tuberculosis

2001 • 458 citations

Discrete Generation of Superoxide and Hydrogen Peroxide by T Cell Receptor Stimulation

2002 • 447 citations

Phagocyte Impotence Caused by an Invasive Bacterial Adenylate Cyclase

1982 • 438 citations

Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling

2001 • 433 citations

Reactive oxygen species as mediators of angiotensin II signaling

2000 • 424 citations

NPAS2: A Gas-Responsive Transcription Factor

2002 • 422 citations

Proteomics gives insight into the regulatory function of chloroplast thioredoxins

2002 • 409 citations

Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69

2002 • 398 citations

Metabolic Enzymes of Mycobacteria Linked to Antioxidant Defense by a Thioredoxin-Like Protein

2002 • 394 citations

Revisiting the stringent response, ppGpp and starvation signaling

2001 • 366 citations

MICALs, a Family of Conserved Flavoprotein Oxidoreductases, Function in Plexin-Mediated Axonal Repulsion

2002 • 351 citations

Evidence for Antibody-Catalyzed Ozone Formation in Bacterial Killing and Inflammation

2002 • 350 citations

Environmental-Dependent Acceleration of a Developmental Switch: The Floral Transition

2000 • 317 citations

Structural mimicry in bacterial virulence

2001 • 310 citations

Direct nitric oxide signal transduction via nitrosylation of iron-sulfur centers in the SoxR transcription activator

2000 • 304 citations

Hydrogen Peroxide Generated during Cellular Insulin Stimulation Is Integral to Activation of the Distal Insulin Signaling Cascade in 3T3-L1 Adipocytes

2001 • 299 citations

Cytolysin-Mediated Translocation (CMT)

2001 • 297 citations

Regulation of inducible peroxide stress responses

2002 • 285 citations

A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell

2001 • 282 citations

Compartmentalization of bicarbonate‐sensitive adenylyl cyclase in distinct signaling microdomains

2002 • 281 citations

Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases

2002 • 281 citations

Molecular Determinants of Selectivity in 5-Hydroxytryptamine1B Receptor-G Protein Interactions

1997 • 277 citations

Calmodulin activates prokaryotic adenylate cyclase.

1980 • 276 citations

Nitric Oxide Regulates Cell Proliferation during Drosophila Development

1996 • 255 citations

Nerve Growth Factor-induced Neuronal Differentiation Requires Generation of Rac1-regulated Reactive Oxygen Species

2000 • 248 citations

Regulation of Peroxiredoxin I Activity by Cdc2-mediated Phosphorylation

2002 • 241 citations

Hematopoietic Growth Factors Signal Through the Formation of Reactive Oxygen Species

1999 • 239 citations

Effects of anthrax toxin components on human neutrophils

1985 • 224 citations

Mechanism of c-fos induction by active oxygen.

1992 • 224 citations

The OhrR repressor senses organic hydroperoxides by reversible formation of a cysteine-sulfenic acid derivative

2002 • 223 citations

Requirement for Type 2 NO Synthase for IL-12 Signaling in Innate Immunity

1999 • 198 citations

Maneuvering in the Complex Path from Genotype to Phenotype

2002 • 188 citations

Excitation-Transcription Coupling: Signaling by Ion Channels to the Nucleus

2003 • 164 citations

Oxidants Painting the Cysteine Chapel

2002 • 150 citations

Innate Immune Induction of the Adaptive Immune Response

1999 • 145 citations

Requirement of Hydrogen Peroxide Generation in TGF-β1 Signal Transduction in Human Lung Fibroblast Cells: Involvement of Hydrogen Peroxide and Ca2+ in TGF-β1-Induced IL-6 Expression

2000 • 145 citations

Role of Macrophage Oxidative Burst in the Action of Anthrax Lethal Toxin

1994 • 138 citations

Nitric Oxide Is an Essential Negative Regulator of Cell Proliferation inXenopusBrain

2001 • 117 citations

CO2/HCO3−-responsive soluble adenylyl cyclase as a putative metabolic sensor

2001 • 115 citations

Signalling and cellular specificity of airway nitric oxide production in pertussis

1999 • 87 citations

The Cysteine-Rich Regions of the Regulatory Domains of Raf and Protein Kinase C as Retinoid Receptors

2000 • 80 citations

Nitric oxide synthase is induced in sporulation ofPhysarum polycephalum

2001 • 77 citations

[29] Redox regulation of protein tyrosine phosphatases by hydrogen peroxide: Detecting sulfenic acid intermediates and examining reversible inactivation

2002 • 54 citations

Nobel Prize for NO research

1998 • 37 citations