Reprogramming of the Macrophage Transcriptome in Response to Interferon-γ and Mycobacterium tuberculosis

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Cell Signaling by Receptor Tyrosine Kinases

2010 • 7,477 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Cell Signaling by Receptor Tyrosine Kinases

2000 • 3,570 citations

NAD(P)H Oxidase

2000 • 2,902 citations

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

Functional Discovery via a Compendium of Expression Profiles

2000 • 2,581 citations

Production of large amounts of hydrogen peroxide by human tumor cells.

1991 • 2,465 citations

An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.

1993 • 2,410 citations

Disseminated tuberculosis in interferon gamma gene-disrupted mice.

1993 • 1,982 citations

Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.

1983 • 1,918 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays

1998 • 1,781 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways

1998 • 1,565 citations

Iron Metabolism in Pathogenic Bacteria

2000 • 1,480 citations

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1995 • 1,454 citations

Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens

2000 • 1,429 citations

Identification of nitric oxide synthase as a protective locus against tuberculosis

1997 • 1,161 citations

REGULATION OF GENE EXPRESSION BY REACTIVE OXYGEN

1999 • 1,102 citations

Mouse model of X–linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

1995 • 920 citations

Deactivation of macrophages by transforming growth factor-β

1988 • 876 citations

PKR; a sentinel kinase for cellular stress

1999 • 823 citations

Induction of Direct Antimicrobial Activity Through Mammalian Toll-Like Receptors

2001 • 709 citations

Peroxynitrite reductase activity of bacterial peroxiredoxins

2000 • 673 citations

DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.

1996 • 630 citations

The H2O2 Stimulon in Saccharomyces cerevisiae

1998 • 564 citations

Interferon regulatory factors: the next generation

1999 • 550 citations

Structural Basis of the Redox Switch in the OxyR Transcription Factor

2001 • 544 citations

Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages

1995 • 532 citations

Nitric oxide and the regulation of gene expression

2001 • 529 citations

Phenotype of Mice and Macrophages Deficient in Both Phagocyte Oxidase and Inducible Nitric Oxide Synthase

1999 • 512 citations

Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.

1990 • 507 citations

Essential Role for the dsRNA-Dependent Protein Kinase PKR in Innate Immunity to Viral Infection

2000 • 491 citations

A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection

1999 • 483 citations

Generation and analysis of 280,000 human expressed sequence tags.

1996 • 474 citations

Transcriptional regulation and function during the human cell cycle

2001 • 462 citations

Regional and strain-specific gene expression mapping in the adult mouse brain

2000 • 456 citations

Cellular gene expression altered by human cytomegalovirus: Global monitoring with oligonucleotide arrays

1998 • 445 citations

Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide.

1991 • 436 citations

Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell

2000 • 400 citations

Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing

2000 • 400 citations

Secretory Leukocyte Protease Inhibitor: A Macrophage Product Induced by and Antagonistic to Bacterial Lipopolysaccharide

1997 • 390 citations

Improved Statistical Inference from DNA Microarray Data Using Analysis of Variance and A Bayesian Statistical Framework

2001 • 364 citations

Novel homologs of gp91phox

2000 • 356 citations

Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-gamma.

1985 • 356 citations

Nitrosative Stress: Activation of the Transcription Factor OxyR

1996 • 351 citations

Cellular thiols and redox-regulated signal transduction

2001 • 347 citations

Synergistic and additive killing by antimicrobial factors found in human airway surface liquid

2000 • 340 citations

Microbial Pathogenesis of Mycobacterium tuberculosis: Dawn of a Discipline

2001 • 338 citations

Local and Systemic Effects of Intradermal Recombinant Interferon-γ in Patients with Lepromatous Leprosy

1986 • 328 citations

Complex roles of Stat1 in regulating gene expression

2000 • 326 citations

Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1.

1999 • 318 citations

Genome-wide study of aging and oxidative stress response inDrosophilamelanogaster

2000 • 315 citations

THE SOS RESPONSE: Recent Insights into umuDC-Dependent Mutagenesis and DNA Damage Tolerance

2000 • 312 citations

Platelet-derived Growth Factor-induced H2O2 Production Requires the Activation of Phosphatidylinositol 3-Kinase

2000 • 309 citations

Treatment of multidrug-resistant pulmonary tuberculosis with interferon-γ via aerosol

1997 • 309 citations

Genomic Analysis of Gene Expression in C. elegans

2000 • 300 citations

An activity in rat tissues that modifies nitrotyrosine-containing proteins

1998 • 278 citations

Pathogen-specific loss of host resistance in mice lacking the IFN-γ-inducible gene IGTP

2000 • 266 citations

Interferon-Induced Guanylate Binding Protein-1 (GBP-1) Mediates an Antiviral Effect against Vesicular Stomatitis Virus and Encephalomyocarditis Virus

1999 • 265 citations

Large-Scale Monitoring of Host Cell Gene Expression during HIV-1 Infection Using cDNA Microarrays

2000 • 256 citations

Mycobacterium tuberculosis Inhibits IFN-γ Transcriptional Responses Without Inhibiting Activation of STAT1

1999 • 248 citations

Macrophage-activating factor produced by a T cell hybridoma: physiochemical and biosynthetic resemblance to gamma-interferon.

1983 • 236 citations

A unique set of polypeptides is induced by γ interferon in addition to those induced in common with α and β interferons

1983 • 234 citations

Chemokines Induced by Infection of Mononuclear Phagocytes with Mycobacteria and Present in Lung Alveoli during Active Pulmonary Tuberculosis

1998 • 231 citations

Activation changes the spectrum but not the diversity of genes expressed by T cells

1999 • 227 citations

A New Superoxide-generating Oxidase in Murine Osteoclasts

2001 • 218 citations

How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis

2000 • 212 citations

Requirement for Type 2 NO Synthase for IL-12 Signaling in Innate Immunity

1999 • 198 citations

Interaction of Pseudomonas aeruginosa with epithelial cells: Identification of differentially regulated genes by expression microarray analysis of human cDNAs

2000 • 179 citations

The transcriptional responses of respiratory epithelial cells toBordetella pertussisreveal host defensive and pathogen counter-defensive strategies

2000 • 154 citations

A semi-automated micro-assay for H2O2 release by human blood monocytes and mouse peritoneal macrophages

1985 • 152 citations

[3] Aconitases: A class of metalloproteins highly sensitive to nitric oxide synthesis

1996 • 142 citations

Nitric oxide upregulates expression of DNA-PKcs to protect cells from DNA-damaging anti-tumour agents

2000 • 125 citations

Host microarray analysis reveals a role for the Salmonella response regulator phoP in human macrophage cell death

2001 • 124 citations

Monitoring Cellular Responses to Listeria monocytogenes with Oligonucleotide Arrays

2000 • 123 citations

The cytochrome b-558 molecules involved in the fibroblast and polymorphonuclear leucocyte superoxide-generating NADPH oxidase systems are structurally and genetically distinct

1993 • 119 citations

Inactivation of zinc finger transcription factors provides a mechanism for a gene regulatory role of nitric oxide

2000 • 118 citations

Genetic Responses to Free Radicals: Homeostasis and Gene Control

2000 • 112 citations

Host Gene Regulation During Coxsackievirus B3 Infection in Mice

2000 • 111 citations

Administration of recombinant interferon gamma to cancer patients enhances monocyte secretion of hydrogen peroxide.

1985 • 110 citations

Inhibition of interferon-gamma-mediated activation in mouse macrophages treated with lipoarabinomannan

1990 • 86 citations

Putting the brakes on innate immunity: a regulatory role for CD200?

2001 • 78 citations

Similar responses by macrophages from young and old mice infected with Mycobacterium tuberculosis

1998 • 30 citations

Glyceraldehyde-3-phosphate Dehydrogenase: A Target for Nitric Oxide Signaling

1995 • 12 citations