A genomic perspective on vitamin D signaling.

The Human Genome Browser at UCSC

2002 • 9,920 citations

Translating the Histone Code

2001 • 9,488 citations

High-Resolution Profiling of Histone Methylations in the Human Genome

2007 • 6,479 citations

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

2007 • 3,994 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

Genome-Wide Mapping of in Vivo Protein-DNA Interactions

2007 • 2,764 citations

The ENCODE (ENCyclopedia Of DNA Elements) Project

2004 • 2,327 citations

Nuclear Receptors and Lipid Physiology: Opening the X-Files

2001 • 2,040 citations

TRANSFAC(R): transcriptional regulation, from patterns to profiles

2003 • 2,010 citations

Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals

2005 • 1,895 citations

Nuclear Hormone Receptors and Gene Expression

2001 • 1,538 citations

Estrogen Receptor-α Directs Ordered, Cyclical, and Combinatorial Recruitment of Cofactors on a Natural Target Promoter

2003 • 1,422 citations

Applied bioinformatics for the identification of regulatory elements

2004 • 1,210 citations

Anatomical Profiling of Nuclear Receptor Expression Reveals a Hierarchical Transcriptional Network

2006 • 952 citations

Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.

1996 • 922 citations

The nuclear receptor ligand-binding domain: structure and function

1998 • 829 citations

The Crystal Structure of the Nuclear Receptor for Vitamin D Bound to Its Natural Ligand

2000 • 802 citations

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex

1999 • 733 citations

Two nuclear signalling pathways for vitamin D

1993 • 559 citations

Tissue-specific transcriptional regulation has diverged significantly between human and mouse

2007 • 520 citations

The SRC family of nuclear receptor coactivators

2000 • 515 citations

Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53.

1994 • 514 citations

Integrative analysis of the cancer transcriptome

2005 • 494 citations

Genome-wide Prediction of Mammalian Enhancers Based on Analysis of Transcription-Factor Binding Affinity

2006 • 481 citations

A novel protein complex that interacts with the vitamin D₃ receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system

1998 • 391 citations

The Role of Corepressors in Transcriptional Regulation by Nuclear Hormone Receptors

2004 • 324 citations

Vitamin D: More Than a “Bone-a-Fide” Hormone

2003 • 295 citations

Comparison of complete nuclear receptor sets from the human, Caenorhabditis elegans and Drosophila genomes

2001 • 254 citations

Regulation of the human p21(waf1/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptor

2006 • 246 citations

Activation of Receptor Activator of NF-κB Ligand Gene Expression by 1,25-Dihydroxyvitamin D₃ Is Mediated through Multiple Long-Range Enhancers

2006 • 219 citations

Multiple parameters control the selectivity of nuclear receptors for their response elements. Selectivity and promiscuity in response element recognition by retinoic acid receptors and retinoid X receptors.

1993 • 207 citations

The Human Transient Receptor Potential Vanilloid Type 6 Distal Promoter Contains Multiple Vitamin D Receptor Binding Sites that Mediate Activation by 1,25-Dihydroxyvitamin D3 in Intestinal Cells

2006 • 206 citations

The Human Peroxisome Proliferator-activated Receptor δ Gene is a Primary Target of 1α,25-Dihydroxyvitamin D3 and its Nuclear Receptor

2005 • 205 citations

Genetic signatures of differentiation induced by 1alpha,25-dihydroxyvitamin D3 in human colon cancer cells.

2003 • 203 citations

Co‐repressors 2000

2000 • 201 citations

Vitamin D Growth Inhibition of Breast Cancer Cells: Gene Expression Patterns Assessed by cDNA Microarray

2003 • 200 citations

Vitamin D and breast cancer: insights from animal models

2004 • 199 citations

Mechanisms of Nuclear Signalling by Vitamin D3. Interplay with Retinoid and Thyroid Hormone Signalling

1995 • 186 citations

1,25-Dihydroxyvitamin D3 Stimulates Cyclic Vitamin D Receptor/Retinoid X Receptor DNA-Binding, Co-activator Recruitment, and Histone Acetylation in Intact Osteoblasts

2005 • 186 citations

Gene Regulation by Vitamin D3

1998 • 185 citations

Ligand Modulates the Conversion of DNA-Bound Vitamin D₃ Receptor (VDR) Homodimers into VDR-Retinoid X Receptor Heterodimers

1994 • 182 citations

VDR-Alien: a novel, DNA-selective vitamin D3 receptor-corepressor partnership

2000 • 180 citations

Interaction between retinoic acid and vitamin D signaling pathways.

1993 • 171 citations

Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II.

1996 • 162 citations

Enhancers Located within Two Introns of the Vitamin D Receptor Gene Mediate Transcriptional Autoregulation by 1,25-Dihydroxyvitamin D₃

2006 • 158 citations

Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching

2004 • 152 citations

Tumor cell‐specific cytotoxicity by targeting cell cycle checkpoints

2003 • 148 citations

Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells

2004 • 141 citations

Natural Vitamin D₃ Response Elements Formed by Inverted Palindromes: Polarity-Directed Ligand Sensitivity of Vitamin D₃ Receptor-Retinoid X Receptor Heterodimer-Mediated Transactivation

1995 • 139 citations

Spatio-temporal Activation of Chromatin on the Human CYP24 Gene Promoter in the Presence of 1α,25-Dihydroxyvitamin D3

2005 • 138 citations

Analysis of vitamin D‐regulated gene expression in LNCaP human prostate cancer cells using cDNA microarrays

2003 • 131 citations

Genome-wide mapping and analysis of active promoters in mouse embryonic stem cells and adult organs

2007 • 122 citations

VITAMIN D IN HEALTH AND DISEASE: Vitamin D and the Epidemiology of Prostate Cancer

2005 • 117 citations

PPARδ status and Apc-mediated tumourigenesis in the mouse intestine

2004 • 116 citations

Molecular activity of 1,25-dihydroxyvitamin D3 in primary cultures of human prostatic epithelial cells revealed by cDNA microarray analysis

2004 • 110 citations

Specificity and flexibility of vitamin D signaling. Modulation of the activation of natural vitamin D response elements by thyroid hormone.

1994 • 107 citations

Eukaryotic transcriptional regulatory complexes: cooperativity from near and afar

2003 • 104 citations

Selective use of multiple vitamin D response elements underlies the 1 ,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene

2007 • 103 citations

Regulation of multiple insulin-like growth factor binding protein genes by 1 ,25-dihydroxyvitamin D3

2005 • 101 citations

PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation

2007 • 100 citations

Two Distinct Coactivators, DRIP/Mediator and SRC/p160, Are Differentially Involved in Vitamin D Receptor Transactivation during Keratinocyte Differentiation

2003 • 89 citations

The Effects of 1α,25-Dihydroxyvitamin D3 on the Expression of DNA Replication Genes

2004 • 78 citations

Thyroid hormone receptor functions as monomeric ligand-induced transcription factor on octameric half-sites. Consequences also for dimerization.

1994 • 77 citations

In vivo function of VDR in gene expression-VDR knock-out mice

1999 • 76 citations

Another Piece of the p27Kip1 Puzzle

2007 • 75 citations

Regulation of the human cyclin C gene via multiple vitamin D3-responsive regions in its promoter

2005 • 71 citations

Profiling 1,25-dihydroxyvitamin D3-regulated gene expression by microarray analysis

2004 • 71 citations

Regulation of Keratinocyte Growth, Differentiation, and Vitamin D Metabolism by Analogs of 1,25-Dihydroxyvitamin D

1993 • 70 citations

Contribution of endogenously expressed Trp1 to a Ca²+‐selective, store‐operated Ca²⁺entry pathway

2001 • 69 citations

Distinct HDACs regulate the transcriptional response of human cyclin-dependent kinase inhibitor genes to trichostatin A and 1α,25-dihydroxyvitamin D 3

2007 • 68 citations

Functional characterization of vitamin D responding regions in the human 5-Lipoxygenase gene

2007 • 68 citations

Molecular Cloning and Chromosomal Localization of the Human Cyclin C (CCNC) and Cyclin E (CCNE) Genes: Deletion of theCCNCGene in Human Tumors

1996 • 66 citations

Ligand-triggered stabilization of vitamin D Receptor/Retinoid X receptor heterodimer conformations on DR4-type response elements

2000 • 65 citations

Response element selectivity for heterodimerization of vitamin D receptors with retinoic acid and retinoid X receptors

1994 • 64 citations

Synergistic Activation of the Prolactin Promoter by Vitamin D Receptor and GHF-1: Role of the Coactivators, CREB-Binding Protein and Steroid Hormone Receptor Coactivator-1 (SRC-1)

1999 • 60 citations

CCAAT/Enhancer-Binding Protein δ: A Molecular Target of 1,25-Dihydroxyvitamin D3 in Androgen-Responsive Prostate Cancer LNCaP Cells

2005 • 57 citations

1,25-Dihydroxyvitamin D3 induces expression of the Wnt signaling co-regulator LRP5 via regulatory elements located significantly downstream of the gene's transcriptional start site

2007 • 50 citations

Prediction of Genomic Functional Elements

2006 • 45 citations

Thyroid Hormone and Retinoic Acid Receptors Form Heterodimers with Retinoid X Receptors on Direct Repeats, Palindromes, and Inverted Palindromes

1994 • 38 citations

Trichostatin A and Structurally Related Histone Deacetylase Inhibitors Induce 5-Lipoxygenase Promoter Activity

2003 • 33 citations

Vitamin D-retinoid association: molecular basis and clinical applications.

1996 • 31 citations

Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site

2006 • 30 citations

Transcriptional regulation at a glance

2007 • 28 citations