Tumor cell‐specific cytotoxicity by targeting cell cycle checkpoints

HDAC6 is a microtubule-associated deacetylase

2002 • 2,214 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

Histone deacetylases and cancer: causes and therapies

2001 • 1,833 citations

Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

2002 • 1,497 citations

Histone deacetylase inhibitor selectively induces p21 ^WAF1 expression and gene-associated histone acetylation

2000 • 1,091 citations

Microtubules containing acetylated alpha-tubulin in mammalian cells in culture.

1987 • 833 citations

Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

2001 • 729 citations

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo.

2000 • 608 citations

Mechanism-Based Target Identification and Drug Discovery in Cancer Research

2000 • 607 citations

Kinetochore Localization of Murine Bub1 Is Required for Normal Mitotic Timing and Checkpoint Response to Spindle Damage

1997 • 543 citations

p21 ^WAF1 is required for butyrate-mediated growth inhibition of human colon cancer cells

1998 • 530 citations

The HP1 protein family: getting a grip on chromatin

2000 • 476 citations

Histone Deacetylase Inhibition Selectively Alters the Activity and Expression of Cell Cycle Proteins Leading to Specific Chromatin Acetylation and Antiproliferative Effects

1999 • 394 citations

Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice

2000 • 388 citations

CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint

2000 • 385 citations

TAT-Mediated Protein Transduction into Mammalian Cells

2001 • 381 citations

Human Bubr1 Is a Mitotic Checkpoint Kinase That Monitors Cenp-E Functions at Kinetochores and Binds the Cyclosome/APC

1999 • 379 citations

The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review

1999 • 375 citations

Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases

2001 • 355 citations

25 years after the nucleosome model: chromatin modifications

2000 • 338 citations

Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage.

1996 • 266 citations

Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia

2001 • 256 citations

Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia

2001 • 255 citations

Histone Deacetylase Inhibitors Trigger a G2 Checkpoint in Normal Cells That Is Defective in Tumor Cells

2000 • 251 citations

Past and future of the mitotic spindle as an oncology target

2001 • 246 citations

Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells

1996 • 234 citations

Duplication and Maintenance of Heterochromatin Domains

1999 • 199 citations

Mitotic checkpoints: from yeast to cancer

2001 • 196 citations

The ins and outs of nucleosome assembly

2001 • 149 citations

Up-regulation of p21(WAF1/CIP1) by histone deacetylase inhibitors reduces their cytotoxicity.

2001 • 133 citations

Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate

1999 • 114 citations

Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly(ADP-ribose) polymerase cleavage.

2002 • 87 citations

The mammalian centromere: structural domains and the attenuation of chromatin modeling

1999 • 41 citations

Flow Cytometry of Mitotic Cells

1998 • 36 citations