Profiling 1,25-dihydroxyvitamin D3-regulated gene expression by microarray analysis

Nuclear Hormone Receptors and Gene Expression

2001 • 1,538 citations

Combinatorial Control of Gene Expression by Nuclear Receptors and Coregulators

2002 • 1,449 citations

Current Understanding of the Molecular Actions of Vitamin D

1998 • 1,259 citations

1α,25-Dihydroxyvitamin D3 Inhibits Differentiation, Maturation, Activation, and Survival of Dendritic Cells Leading to Impaired Alloreactive T Cell Activation

2000 • 1,253 citations

Structure-Function Relationships in the Vitamin D Endocrine System*

1995 • 1,182 citations

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

2001 • 1,085 citations

Cloning and expression of full-length cDNA encoding human vitamin D receptor.

1988 • 961 citations

Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.

1996 • 922 citations

1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis.

1996 • 729 citations

Neuroendocrinology of the Skin1

2000 • 678 citations

Targeted ablation of the 25-hydroxyvitamin D 1α-hydroxylase enzyme: Evidence for skeletal, reproductive, and immune dysfunction

2001 • 623 citations

Dendritic cell modulation by 1α,25 dihydroxyvitamin D₃and its analogs: A vitamin D receptor-dependent pathway that promotes a persistent state of immaturityin vitroandin vivo

2001 • 591 citations

Genomic instability in Gadd45a-deficient mice

1999 • 499 citations

T1/St2-Deficient Mice Demonstrate the Importance of T1/St2 in Developing Primary T Helper Cell Type 2 Responses

2000 • 476 citations

Neuroendocrinology of the Skin

2000 • 470 citations

Cadherin switching in human prostate cancer progression.

2000 • 403 citations

Expression of CYP3A4, CYP2B6, andCYP2C9 Is Regulated by the Vitamin D Receptor Pathway in Primary Human Hepatocytes

2002 • 350 citations

Transcriptional Control of Intestinal Cytochrome P-4503A by 1α,25-Dihydroxy Vitamin D₃

2001 • 321 citations

Mechanisms of gene regulation by vitamin D3 receptor: a network of coactivator interactions

2000 • 321 citations

Structure-function relationships in the vitamin D endocrine system

1995 • 268 citations

Cancer chemoprevention.

1994 • 254 citations

Target cell metabolism of 1,25-dihydroxyvitamin D3 to calcitroic acid. Evidence for a pathway in kidney and bone involving 24-oxidation

1989 • 246 citations

1-alpha,25-Dihydroxyvitamin D3 (1,25(OH)(2)D(3)) hampers the maturation of fully active immature dendritic cells from monocytes

2001 • 231 citations

Abnormal expression of retinoic acid receptors and keratin 19 by human oral and epidermal squamous cell carcinoma cell lines.

1991 • 209 citations

Sunlight “D”ilemma: risk of skin cancer or bone disease and muscle weakness

2001 • 200 citations

Vitamin D Growth Inhibition of Breast Cancer Cells: Gene Expression Patterns Assessed by cDNA Microarray

2003 • 200 citations

Serum midkine levels are increased in patients with various types of carcinomas

2000 • 189 citations

Inhibition of prostate cancer growth by vitamin D: Regulation of target gene expression

2003 • 180 citations

Cadherin Switching in Human Prostate Cancer Progression

2000 • 179 citations

Topical preparations for the treatment of psoriasis: a systematic review

2002 • 178 citations

Expression Profiling in Squamous Carcinoma Cells Reveals Pleiotropic Effects of Vitamin D3 Analog EB1089 Signaling on Cell Proliferation, Differentiation, and Immune System Regulation

2002 • 177 citations

Modulation of Growth Factor/Cytokine Synthesis and Signaling by 1α,25-Dihydroxyvitamin D3: Implications in Cell Growth and Differentiation

2002 • 168 citations

Distinct roles of osteopontin in host defense activity and tumor survival during squamous cell carcinoma progression in vivo.

1998 • 166 citations

Normal myelopoiesis but abnormal T lymphocyte responses in vitamin D receptor knockout mice

2002 • 153 citations

High expression of S-phase kinase-interacting protein 2, human F-box protein, correlates with poor prognosis in oral squamous cell carcinomas.

2001 • 152 citations

Regulation of Gene Expression by 1α,25-Dihydroxyvitamin D₃and Its Analog EB1089 under Growth-Inhibitory Conditions in Squamous Carcinoma Cells

2001 • 149 citations

Natural Vitamin D₃ Response Elements Formed by Inverted Palindromes: Polarity-Directed Ligand Sensitivity of Vitamin D₃ Receptor-Retinoid X Receptor Heterodimer-Mediated Transactivation

1995 • 139 citations

Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements

2002 • 135 citations

Seocalcitol (EB 1089) A Vitamin D Analogue of Anti-cancer Potential. Background, Design, Synthesis, Pre-clinical and Clinical Evaluation

2000 • 110 citations

Cancer Chemoprevention Using Natural Vitamin D and Synthetic Analogs

2001 • 109 citations

Carnosic acid potentiates the antioxidant and prodifferentiation effects of 1alpha,25-dihydroxyvitamin D3 in leukemia cells but does not promote elevation of basal levels of intracellular calcium.

2003 • 101 citations

Cyr61, a Member of the CCN Family, Is Required for MCF-7 Cell Proliferation: Regulation by 17β-Estradiol and Overexpression in Human Breast Cancer

2001 • 99 citations

Retinoid X Receptor (RXR) Ligands Activate the Human 25-Hydroxyvitamin D3-24-hydroxylase Promoter via RXR Heterodimer Binding to Two Vitamin D-responsive Elements and Elicit Additive Effects with 1,25-Dihydroxyvitamin D3

1997 • 89 citations

Suppression of a squamous cell carcinoma (SCC)-related serpin, SCC antigen, inhibits tumor growth with increased intratumor infiltration of natural killer cells.

2001 • 83 citations

A new series of vitamin D analogs is highly active for clonal inhibition, differentiation, and induction of WAF1 in myeloid leukemia

1996 • 81 citations

Recent progress in enzymology and molecular biology of enzymes involved in vitamin D metabolism.

1995 • 79 citations

Action of Low Calcemic 1 ,25-Dihydroxyvitamin D3 Analogue EB1089 in Head and Neck Squamous Cell Carcinoma

2001 • 77 citations

Cytokine signaling through the novel tyrosine kinase RAFTK in Kaposi's sarcoma cells.

1997 • 72 citations

Inhibition of F-Box Protein p45SKP2 Expression and Stabilization of Cyclin-Dependent Kinase Inhibitor p27KIP1 in Vitamin D Analog-Treated Cancer Cells

2003 • 61 citations

Metabolism of the vitamin D analog EB 1089: Identification of in vivo and in vitro liver metabolites and their biological activities∗

1997 • 56 citations

Regulation of Gene Expression by 1 ,25-Dihydroxyvitamin D3 and Its Analog EB1089 under Growth-Inhibitory Conditions in Squamous Carcinoma Cells

2001 • 47 citations

Expression Profiling in Squamous Carcinoma Cells Reveals Pleiotropic Effects of Vitamin D3 Analog EB1089 Signaling on Cell Proliferation, Differentiation, and Immune System Regulation

2002 • 47 citations

Synergistic Induction of HL60 Cell Differentiation by Ketoconazole and 1-Desoxy Analogues of Vitamin D3

1997 • 32 citations

Molecular Pathways Involved in the Antineoplastic Effects of Calcitriol on Insulinoma Cells

2003 • 27 citations

Amphiregulin Is a Vitamin D 3 Target Gene in Squamous Cell and Breast Carcinoma

2001 • 26 citations

Cyr61, a Member of the CCN Family, Is Required for MCF-7 Cell Proliferation: Regulation by 17 -Estradiol and Overexpression in Human Breast Cancer

2001 • 21 citations