Somatostatin receptors in gastroentero-pancreatic neuroendocrine tumours.

Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

1973 • 3,509 citations

Somatostatin and Its Receptor Family

1999 • 1,597 citations

Somatostatin receptor scintigraphy with [111In-DTPA-d-Phe1]- and [123I-Tyr3]-octreotide: the Rotterdam experience with more than 1000 patients

1993 • 1,563 citations

SMS 201–995: A very potent and selective octapeptide analogue of somatostatin with prolonged action

1982 • 1,317 citations

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

Receptors for Dopamine and Somatostatin: Formation of Hetero-Oligomers with Enhanced Functional Activity

2000 • 866 citations

Treatment of the Malignant Carcinoid Syndrome

1986 • 852 citations

The Role of Somatostatin and Its Analogs in the Diagnosis and Treatment of Tumors

1991 • 827 citations

SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile

2002 • 673 citations

Somatostatin receptor sst1–sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands

2001 • 641 citations

Molecular Biology of Somatostatin Receptors*

1995 • 636 citations

LOCALISATION OF ENDOCRINE-RELATED TUMOURS WITH RADIOIODINATED ANALOGUE OF SOMATOSTATIN

1989 • 607 citations

Somatostatin

1983 • 581 citations

Concomitant expression of several peptide receptors in neuroendocrine tumours: molecular basis for in vivo multireceptor tumour targeting

2003 • 555 citations

Subtypes of the Somatostatin Receptor Assemble as Functional Homo- and Heterodimers

2000 • 528 citations

Oncological applications of somatostatin analogues.

1988 • 494 citations

The Pathophysiological Consequences of Somatostatin Receptor Internalization and Resistance

2003 • 468 citations

Karnofsky memorial lecture. An odyssey in the land of small tumors.

1987 • 465 citations

Phase I study of peptide receptor radionuclide therapy with [111In-DTPA0]octreotide: The rotterdam experience

2002 • 429 citations

Stimulatory and Inhibitory Effects of Purified Hypothalamic Extracts on Growth Hormone Release from Rat Pituitaryin Vitro¹

1968 • 429 citations

Treatment of patients with gastro-entero-pancreatic (GEP) tumours with the novel radiolabelled somatostatin analogue [177Lu-DOTA0,Tyr3]octreotate

2003 • 415 citations

Molecular pharmacology of somatostatin receptor subtypes

1997 • 411 citations

Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization.

1993 • 387 citations

Endocytosis and recycling of G protein-coupled receptors

1997 • 342 citations

G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins

1996 • 332 citations

Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: mediation by human somatostatin receptor subtypes SSTR1 and SSTR2.

1994 • 329 citations

Expression of somatostatin receptor types 1–5 in 81 cases of gastrointestinal and pancreatic endocrine tumors

2002 • 314 citations

Homo- and Heterodimerization of Somatostatin Receptor Subtypes

2001 • 312 citations

Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms.

1995 • 300 citations

Indium-111-pentetreotide prolongs survival in gastroenteropancreatic malignancies

2002 • 278 citations

Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.

1999 • 276 citations

Identification of somatostatin receptor subtypes and an implication for the efficacy of somatostatin analogue SMS 201-995 in treatment of human endocrine tumors.

1994 • 271 citations

Cloning and expression of a novel mouse somatostatin receptor (SSTR2B)

1992 • 270 citations

G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins

1996 • 264 citations

Heterodimerization of Somatostatin and Opioid Receptors Cross-modulates Phosphorylation, Internalization, and Desensitization

2002 • 259 citations

Dual pathways of internalization of the cholecystokinin receptor.

1995 • 236 citations

111In- and 90Y-DOTA-Lanreotide: Results and implications of the MAURITIUS trial

2002 • 233 citations

Somatostatin receptors in human cancer: Incidence, characteristics, functional correlates and clinical implications

1992 • 224 citations

Molecular pharmacology of somatostatin receptors

1994 • 216 citations

Prospective study of the antitumor efficacy of long‐term octreotide treatment in patients with progressive metastatic gastrinoma

2002 • 213 citations

Treatment of the carcinoid syndrome with the longacting somatostatin analogue lanreotide: a prospective study in 39 patients.

1996 • 205 citations

Expression of mRNA for all five human somatostatin receptors (hSSTR1-5) in pituitary tumors

1994 • 188 citations

Somatostatin analogue scintigraphy in carcinoid tumours

1993 • 182 citations

Molecular biology of somatostatin receptors

1995 • 178 citations

Treatment of Metastatic Islet Cell Carcinoma with a Somatostatin Analogue (SMS 201-995)

1987 • 170 citations

SOM230: A New Somatostatin Peptidomimetic with Potent Inhibitory Effects on the Growth Hormone/Insulin-Like Growth Factor-I Axis in Rats, Primates, and Dogs

2002 • 165 citations

Multiple Gene Transcripts of the Somatostatin Receptor SSTR2: Tissue-Selective Distribution and cAMP Regulation

1993 • 165 citations

Somatostatin Inhibits Tumor Angiogenesis and Growth via Somatostatin Receptor-3-Mediated Regulation of Endothelial Nitric Oxide Synthase and Mitogen-Activated Protein Kinase Activities

2003 • 163 citations

Demonstration of Enhanced Potency of a Chimeric Somatostatin-Dopamine Molecule, BIM-23A387, in Suppressing Growth Hormone and Prolactin Secretion from Human Pituitary Somatotroph Adenoma Cells

2002 • 157 citations

Characterization of the antiproliferative signal mediated by the somatostatin receptor subtype sst5

1997 • 137 citations

Immunohistochemical Localization of Somatostatin Receptors sst2A in Human Tumors

1998 • 130 citations

sst2 Somatostatin Receptor Mediates Cell Cycle Arrest and Induction of p27

1999 • 130 citations

Somatostatin receptor subtype 2 sensitizes human pancreatic cancer cells to death ligand-induced apoptosis

2002 • 125 citations

Induction of wild-type p53, Bax, and acidic endonuclease during somatostatin-signaled apoptosis in MCF-7 human breast cancer cells

1998 • 123 citations

Somatostatin and somatostatin analogues: diagnostic and therapeutic uses

2002 • 123 citations

Endocytosis and recycling of G protein-coupled receptors

1997 • 122 citations

Somatostatin receptors and their subtypes in human tumors and in peritumoral vessels

1996 • 120 citations

Immunohistochemical Detection of Somatostatin Receptor Subtypes sst1 and sst2A in Human Somatostatin Receptor Positive Tumors

1999 • 119 citations

C-Terminal Region of Human Somatostatin Receptor 5 Is Required for Induction of Rb and G₁Cell Cycle Arrest

1999 • 118 citations

Antiproliferative Effect of Somatostatin and Analogs

2001 • 116 citations

Inhibition of growth and metastatic progression of pancreatic carcinoma in hamster after somatostatin receptor subtype 2 (sst2) gene expression and administration of cytotoxic somatostatin analog AN-238

2000 • 113 citations

sst2 Somatostatin Receptor Mediates Negative Regulation of Insulin Receptor Signaling through the Tyrosine Phosphatase SHP-1

1998 • 113 citations

Immunocytochemical detection of somatostatin receptors sst1, sst2A, sst2B, and sst3 in paraffin-embedded breast cancer tissue using subtype-specific antibodies.

1998 • 111 citations

Expression of Somatostatin Receptors in Normal, Inflamed, and Neoplastic Human Gastrointestinal Tissues

1994 • 110 citations

Differential Internalization of Somatostatin in COS-7 Cells Transfected with SST₁and SST₂Receptor Subtypes: A Confocal Microscopic Study Using Novel Fluorescent Somatostatin Derivatives¹

1997 • 110 citations

Scintigraphy and radionuclide therapy with [indium-111-labelled-diethyl triamine penta-acetic acid-D-Phe1]-octreotide.

1999 • 101 citations

New somatostatin analogs: will they fulfil old promises?

2002 • 98 citations

Antiangiogenic effects of somatostatin analogues

2002 • 96 citations

In vitro detection of somatostatin receptors in human tumors

1992 • 93 citations

Gene Therapy for Pancreatic Carcinoma: Local and Distant Antitumor Effects after Somatostatin Receptor sst2 Gene Transfer

1999 • 91 citations

Somatostatin analogs: angiogenesis inhibitors with novel mechanisms of action

1997 • 90 citations

Immunohistochemical expression of somatostatin type 2A receptor in neuroendocrine tumors.

1999 • 81 citations

Antitumor effect of in vivo somatostatin receptor subtype 2 gene transfer in primary and metastatic pancreatic cancer models.

2002 • 81 citations

Expression of somatostatin receptor subtypes in breast carcinoma, carcinoid tumor, and renal cell carcinoma.

1995 • 77 citations

Treatment of the Malignant Carcinoid Syndrome

1987 • 75 citations

Nuclear localization of 111In after intravenous injection of [111In-DTPA-D-Phe1]-octreotide in patients with neuroendocrine tumors.

2000 • 67 citations

Somatostatin Receptor Scintigraphy in Carcinoids, Gastrinomas and Cushing’s Syndrome

1994 • 64 citations

Molecular pharmacology of somatostatin receptors

1995 • 64 citations

Immunohistochemical Localization of Somatostatin Receptor sst2A in Human Pancreatic Islets

1998 • 60 citations

Somatostatin Receptor Scintigraphy in Patients with Carcinoid Tumors

1996 • 54 citations

A targeted cytotoxic somatostatin (SST) analogue, AN-238, inhibits the growth of H-69 small-cell lung carcinoma (SCLC) and H-157 non-SCLC in nude mice

2001 • 53 citations

Comparative somatostatin receptor scintigraphy using In-111-DOTA-lanreotide and In-111-DOTA-Tyr3-octreotide versus F-18-FDG-PET for evaluation of somatostatin receptor-mediated radionuclide therapy

2001 • 53 citations

Agonist-dependent Up-regulation of Human Somatostatin Receptor Type 1 Requires Molecular Signals in the Cytoplasmic C-tail

1999 • 51 citations

Internalization of [DOTA°,¹²⁵I‐Tyr³]Octreotide by Somatostatin Receptor–Positive Cells In Vitro and In Vivo: Implications for Somatostatin Receptor–Targeted Radio‐guided Surgery

1999 • 49 citations

C-Terminal Region of Human Somatostatin Receptor 5 Is Required for Induction of Rb and G1 Cell Cycle Arrest

1999 • 48 citations

Somatostatin analogue treatment of neuroendocrine tumours

1996 • 48 citations

Somatostatin analogs: clinical application in relation to human somatostatin receptor subtypes

1995 • 48 citations

Immunohistochemical Detection of Somatostatin Receptor Subtypes sst1 and sst2A in Human Somatostatin Receptor Positive Tumors

1999 • 47 citations

Inhibition of metastatic renal cell carcinomas expressing somatostatin receptors by a targeted cytotoxic analogue of somatostatin AN-238.

2000 • 46 citations

Complete histological regression of metastatic carcinoid tumour after treatment with octreotide

2000 • 40 citations

Development of resistance to a long-acting somatostatin analogue during treatment of two patients with metastatic endocrine pancreatic tumours

1988 • 38 citations

Differential Internalization of Somatostatin in COS-7 Cells Transfected with SST1 and SST2 Receptor Subtypes: A Confocal Microscopic Study Using Novel Fluorescent Somatostatin Derivatives

1997 • 38 citations

Expression of somatostatin receptor subtypes in breast carcinoma, carcinoid tumor, and renal cell carcinoma

1995 • 26 citations

STIMULATORY AND INHIBITORY EFFECTS OF PURIFIED HYPOTHALAMIC EXTRACTS ON GROWTH HORMONE RELEASE FROM RAT PITUITARY IN VITRO

1969 • 24 citations

Tumor regression of an ileal carcinoid under the treatment with the somatostatin analogue SMS 201–995

1988 • 24 citations

Somatostatin receptor imaging of endocrine gastrointestinal tumors.

1992 • 23 citations

Peptide receptors in gut endocrine tumours

1996 • 23 citations

Inhibition of the UCI-107 human ovarian carcinoma cell line by a targeted cytotoxic analog of somatostatin, AN-238

2001 • 22 citations

Immunohistochemical Localization of Somatostatin Receptor sst2A in Human Pancreatic Islets

1998 • 19 citations

Rat somatostatin sst_2(a) and sst_2(b) receptor isoforms mediate opposite effects on cell proliferation

1998 • 19 citations

Phase I study of therapy with Y-90-SMT487 (octreother) in patients with somatostatin receptor (SS-R) positive tumors.

2002 • 18 citations

Oncogenes, growth factors, receptor expression and proliferation markers in digestive neuroendocrine tumours. A critical reappraisal

2001 • 16 citations

Effective treatment of experimental DU-145 prostate cancers with targeted cytotoxic somatostatin analog AN-238

2002 • 15 citations

Prospective study of the antitumor efficacy of long term octreotide treatment in patients with progressive metastatic gastrinoma

2002 • 13 citations

Antitumor effect of BRM

2002 • 7 citations

Long-term survival of patients treated with octreotide for metastatic well differentiated neuroendocrine carcinoma of the lung.

2000 • 5 citations

Deleted Work

1955 • 0 citations