G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

1993 • 907 citations

Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

1993 • 877 citations

Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function

1993 • 873 citations

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

1986 • 781 citations

A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

1993 • 747 citations

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.

1992 • 531 citations

Protein kinases that phosphorylate activated G protein‐coupled receptors

1995 • 520 citations

Structure and mechanism of the G protein-coupled receptor kinases.

1993 • 480 citations

Binding of G protein beta gamma-subunits to pleckstrin homology domains.

1994 • 479 citations

Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein).

1987 • 478 citations

Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors.

1992 • 445 citations

G protein—coupled receptor kinases

1993 • 434 citations

Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

1988 • 429 citations

Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization

1989 • 415 citations

Pleckstrin Homology Domain-mediated Membrane Association and Activation of the β-Adrenergic Receptor Kinase Requires Coordinate Interaction with Gβγ Subunits and Lipid

1995 • 360 citations

Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart.

1994 • 300 citations

Dual pathways of internalization of the cholecystokinin receptor.

1995 • 236 citations

Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.

1993 • 234 citations

Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor.

1993 • 227 citations

Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution.

1986 • 221 citations

Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family

1991 • 214 citations

Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor.

1995 • 209 citations

Sequential phosphorylation of rhodopsin at multiple sites

1993 • 204 citations

Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.

1994 • 202 citations

Primary and secondary structure of bovine retinal S antigen (48-kDa protein).

1987 • 200 citations

The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain

1992 • 197 citations

Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase.

1992 • 196 citations

Cone arrestin identified by targeting expression of a functional family.

1994 • 172 citations

A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation.

1991 • 166 citations

Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C.

1996 • 165 citations

Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family.

1993 • 159 citations

Effects of Second Intracellular Loop Mutations on Signal Transduction and Internalization of the Gonadotropin-releasing Hormone Receptor

1995 • 158 citations

Polypeptide variants of beta-arrestin and arrestin3

1993 • 156 citations

Desensitization and Internalization of the m2 Muscarinic Acetylcholine Receptor Are Directed by Independent Mechanisms

1995 • 155 citations

Sequestration of muscarinic acetylcholine receptor m2 subtypes. Facilitation by G protein-coupled receptor kinase (GRK2) and attenuation by a dominant-negative mutant of GRK2.

1994 • 150 citations

A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination.

1993 • 146 citations

The carboxyl terminus of the hamster β-adrenergic receptor expressed in mouse L cells is not required for receptor sequestration

1987 • 142 citations

Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family.

1994 • 141 citations

Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family.

1993 • 139 citations

Arrestin-rhodopsin interaction. Multi-site binding delineated by peptide inhibition.

1994 • 136 citations

Regulation of Rhodopsin Dephosphorylation by Arrestin

1989 • 134 citations

A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs.

1990 • 130 citations

Hm1 muscarinic cholinergic receptor internalization requires a domain in the third cytoplasmic loop.

1992 • 129 citations

Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism.

1992 • 129 citations

X‐Arrestin: a new retinal arrestin mapping to the X chromosome

1993 • 116 citations

Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing

1993 • 111 citations

Palmitoylation of luteinizing hormone/human choriogonadotropin receptors in transfected cells. Abolition of palmitoylation by mutation of Cys-621 and Cys-622 residues in the cytoplasmic tail increases ligand-induced internalization of the receptor.

1994 • 111 citations

Visualization of the thyrotropin-releasing hormone receptor and its ligand during endocytosis and recycling.

1995 • 106 citations

Serines and threonines in the gastrin-releasing peptide receptor carboxyl terminus mediate internalization.

1993 • 105 citations

Endothelin-induced Endocytosis of Cell Surface ET @! Receptors

1995 • 102 citations

Amino acid sequences Gly-Pro-Leu-Tyr and Asn-Pro-Glu-Tyr in the submembranous domain of the insulin receptor are required for normal endocytosis.

1991 • 101 citations

Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins.

1994 • 99 citations

A proline-rich region of the third intracellular loop imparts phenotypic beta 1-versus beta 2-adrenergic receptor coupling and sequestration

1994 • 98 citations

Molecular cloning of the S-antigen cDNA from bovine retina

1987 • 94 citations

Members of the G Protein-Coupled Receptor Kinase Family That Phosphorylate the β₂-Adrenergic Receptor Facilitate Sequestration

1996 • 88 citations

New Molecular and Structural Determinants Involved in β2-Adrenergic Receptor Desensitization and Sequestration

1996 • 87 citations

Structure and functions of arrestins

1994 • 86 citations

Direct Observation of Endocytosis of Gastrin Releasing Peptide and Its Receptor

1995 • 85 citations

Visual arrestin binding to rhodopsin. Intramolecular interaction between the basic N terminus and acidic C terminus of arrestin may regulate binding selectivity.

1994 • 85 citations

The arrestin superfamily: cone arrestins are a fourth family

1995 • 82 citations

The conserved NPXnY motif present in the gastrin-releasing peptide receptor is not a general sequestration sequence.

1994 • 73 citations

Location of agonist‐dependent‐phosphorylation sites in the third intracellular loop of muscarinic acetylcholine receptors (m2 subtype)

1994 • 61 citations

Structural organization of the human S-antigen gene. cDNA, amino acid, intron, exon, promoter, in vitro transcription, retina, and pineal gland.

1990 • 60 citations

A truncation mutation in the avian beta-adrenergic receptor causes agonist-induced internalization and GTP-sensitive agonist binding characteristic of mammalian receptors.

1990 • 50 citations

Overlapping multi-site domains of the muscarinic cholinergic Hm1 receptor involved in signal transduction and sequestration.

1994 • 48 citations

Molecular Cloning, Functional Expression and mRNA Analysis of Human Beta-Adrenergic Receptor Kinase 2

1993 • 36 citations

Carboxyl-terminal Domains in the Avian β1-Adrenergic Receptor That Regulate Agonist-promoted Endocytosis

1995 • 31 citations

Identification of a Region Required for Subtype-specific Agonist-induced Sequestration of the m2 Muscarinic Acetylcholine Receptor

1996 • 30 citations

A Segment Corresponding to Amino Acids Val170-Arg182 of Bovine Arrestin is Capable of Binding to Phosphorylated Rhodopsin

1994 • 27 citations

Protein kinase C-mediated phosphorylation of retinal rod outer segment membrane proteins

1989 • 27 citations

Evidence for ATP‐ase activity of arrestin from bovine photoreceptors

1991 • 8 citations