Induction of wild-type p53, Bax, and acidic endonuclease during somatostatin-signaled apoptosis in MCF-7 human breast cancer cells

Cell Growth & Differentiation

1992 • 558 citations

Identification of Deoxyribonuclease II as an Endonuclease Involved in Apoptosis

1993 • 428 citations

Somatostatin receptor scintigraphy with indium-111-DTPA-D-Phe-1-octreotide in man: metabolism, dosimetry and comparison with iodine-123-Tyr-3-octreotide.

1992 • 411 citations

The somatostatin receptor family

1995 • 356 citations

p21Waf1/Cip1 protects against p53-mediated apoptosis of human melanoma cells

1997 • 305 citations

Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms.

1995 • 300 citations

Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3.

1996 • 260 citations

Overexpression of bax sensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis

1996 • 170 citations

Chapter 3 Assays for DNA Fragmentation, Endonucleases, and Intracellular pH and Ca2+ Associated with Apoptosis

1995 • 128 citations

Adenovirus-based transfer of wild-type p53 gene increases ovarian tumor radiosensitivity.

1996 • 115 citations

Induction of the death-promoting genebax-? sensitizes cultured breast-cancer cells to drug-induced apoptosis

1996 • 109 citations

Cell Cycle Dependent Induction of Apoptosis by Somatostatin Analog SMS 201-995 in AtT-20 Mouse Pituitary Cells

1995 • 99 citations

Internalization of the radioiodinated somatostatin analog [125I-Tyr3]octreotide by mouse and human pituitary tumor cells: increase by unlabeled octreotide.

1995 • 98 citations

Somatostatin-14 and its analog octreotide exert a cytostatic effect on GH3 rat pituitary tumor cell proliferation via a transient G0/G1 cell cycle block.

1995 • 94 citations

Endonuclease activities, chromatin structure, and DNA degradation in apoptosis

1994 • 94 citations

The somatostatin receptor SSTR1 is coupled to phosphotyrosine phosphatase activity in CHO-K1 cells.

1994 • 91 citations

Expression of multiple somatostatin receptor genes in AtT-20 cells. Evidence for a novel somatostatin-28 selective receptor subtype.

1994 • 91 citations

Somatostatin Receptor-Binding Peptides Labeled with Technetium-99m: Chemistry and Initial Biological Studies

1996 • 89 citations

Inhibition of Human Breast Cancer Cell (MCF-7) Growthin Vitroby the Somatostatin Analog SMS 201-995: Effects on Cell Cycle Parameters and Apoptotic Cell Death*

1991 • 82 citations

Abrogation of p53-induced cell cycle arrest by c-Myc: evidence for an inhibitor of p21WAF1/CIP1/SDI1.

1995 • 79 citations

Expression of somatostatin receptor subtypes in breast carcinoma, carcinoid tumor, and renal cell carcinoma.

1995 • 77 citations

Apoptosis and the cell cycle.

1994 • 76 citations

Somatostatin Inhibits PC Cl3 Thyroid Cell Proliferation through the Modulation of Phosphotyrosine Phosphatase Activity

1996 • 71 citations

Octapeptide somatostatin analog SMS 201-995 induces translocation of intracellular PTP1C to membranes in MCF-7 human breast adenocarcinoma cells.

1996 • 70 citations

Estrogen regulates somatostatin receptor subtype 2 messenger ribonucleic acid expression in human breast cancer cells.

1996 • 55 citations

G Protein Coupled Receptor Signaled Apoptosis Is Associated with Activation of a Cation Insensitive Acidic Endonuclease and Intracellular Acidification

1998 • 50 citations

Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin

1996 • 48 citations

Alzheimer's Disease-Linked Mutation of Presenilin 2 (N141I-PS2) Drastically Lowers APPα Secretion: Control by the Proteasome

1998 • 35 citations

Tamoxifen and somatostatin affect tumours by inducing apoptosis

1995 • 32 citations

Induction of apoptosis but not G1 arrest by expression of the wild-type p53 gene in small cell lung carcinoma.

1996 • 25 citations