sst2 Somatostatin Receptor Mediates Cell Cycle Arrest and Induction of p27

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Principles of CDK regulation

1995 • 3,267 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

D-type cyclins

1995 • 978 citations

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

1995 • 959 citations

Cyclin E-CDK2 is a regulator of p27Kip1.

1997 • 915 citations

Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.

1995 • 910 citations

Translational Control of p27 ^Kip1 Accumulation During the Cell Cycle

1996 • 864 citations

The Role of Somatostatin and Its Analogs in the Diagnosis and Treatment of Tumors

1991 • 827 citations

Cyclin-Dependent Regulation of G ₁ in Mammalian Fibroblasts

1993 • 767 citations

Protein tyrosine phosphatases in signal transduction

1997 • 766 citations

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

1993 • 756 citations

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation

1994 • 742 citations

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1

1997 • 698 citations

Requirement of p27 ^Kip1 for Restriction Point Control of the Fibroblast Cell Cycle

1996 • 683 citations

Negative Regulation of G1 in Mammalian Cells: Inhibition of Cyclin E-Dependent Kinase by TGF-β

1993 • 578 citations

Molecular pharmacology of somatostatin receptor subtypes

1997 • 411 citations

Ras Links Growth Factor Signaling to the Cell Cycle Machinery via Regulation of Cyclin D1 and the Cdk Inhibitor p27^KIP1

1997 • 409 citations

Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: mediation by human somatostatin receptor subtypes SSTR1 and SSTR2.

1994 • 329 citations

Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms.

1995 • 300 citations

Somatostatin analogues inhibit growth of pancreatic cancer by stimulating tyrosine phosphatase.

1989 • 288 citations

Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3.

1996 • 260 citations

Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice.

1993 • 243 citations

Involvement of p27KIP1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody.

1996 • 228 citations

Abrogation of p27 by cDNA Antisense Suppresses Quiescence (G0 State) in Fibroblasts

1996 • 203 citations

Ras-stimulated Extracellular Signal-related Kinase 1 and RhoA Activities Coordinate Platelet-derived Growth Factor-induced G1 Progression through the Independent Regulation of Cyclin D1 and p27KIP1

1997 • 193 citations

Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction

1994 • 182 citations

Synthesis and biological activity of highly potent octapeptide analogs of somatostatin.

1986 • 173 citations

The Tyrosine Phosphatase SHP-1 Associates with the sst2 Somatostatin Receptor and Is an Essential Component of sst2-mediated Inhibitory Growth Signaling

1997 • 168 citations

G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells.

1997 • 155 citations

Interferon-induces expression of cyclin-dependent kinase-inhibitors p21WAF1 and p27Kip1 that prevent activation of cyclin-dependent kinase by CDK-activating kinase (CAK)

1998 • 114 citations

sst2 Somatostatin Receptor Mediates Negative Regulation of Insulin Receptor Signaling through the Tyrosine Phosphatase SHP-1

1998 • 113 citations

The Somatostatin Receptor in the GI Tract

1992 • 100 citations

Cell Cycle Dependent Induction of Apoptosis by Somatostatin Analog SMS 201-995 in AtT-20 Mouse Pituitary Cells

1995 • 99 citations

Somatostatin-14 and its analog octreotide exert a cytostatic effect on GH3 rat pituitary tumor cell proliferation via a transient G0/G1 cell cycle block.

1995 • 94 citations

p27Kip1: a key mediator of retinoic acid induced growth arrest in the SMS–KCNR human neuroblastoma cell line

1998 • 92 citations

Lack of relationship between CDK activity and G1 cyclin expression in breast cancer cells

1998 • 89 citations

The role of p27Kip1 in gamma interferon-mediated growth arrest of mammary epithelial cells and related defects in mammary carcinoma cells

1997 • 86 citations

Inhibition of Human Breast Cancer Cell (MCF-7) Growthin Vitroby the Somatostatin Analog SMS 201-995: Effects on Cell Cycle Parameters and Apoptotic Cell Death*

1991 • 82 citations

Expression of the v-Src oncoprotein in fibroblasts disrupts normal regulation of the CDK inhibitor p27 and inhibits quiescence

1998 • 52 citations

Differential control of cyclins D1 and D3 and the cdk inhibitor p27Kip1 by diverse signalling pathways in Swiss 3T3 cells

1997 • 47 citations

Overexpression of p27Kip1 inhibits the growth of both normal and transformed human mammary epithelial cells.

1998 • 43 citations

Epidermal growth factor binding and biologic effects on mouse pancreatic acini

1983 • 41 citations

Effect of TGF-beta1 on cell cycle regulatory proteins in LPS-stimulated normal mouse B lymphocytes.

1997 • 30 citations

Staurosporine-induced G1 arrest is associated with the induction and accumulation of cyclin-dependent kinase inhibitors.

1996 • 25 citations

Solubilization and characterization of active somatostatin receptors from rat pancreas.

1990 • 25 citations

The cdk2 Binding Domain of p27KipCorrelates with the Inhibition of the Kinase Activity of cdk2/Cyclin Complexes

1996 • 8 citations