A targeted cytotoxic somatostatin (SST) analogue, AN-238, inhibits the growth of H-69 small-cell lung carcinoma (SCLC) and H-157 non-SCLC in nude mice

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model

1998 • 2,040 citations

Recombinant Toxins for Cancer Treatment

1991 • 308 citations

Cancer chemotherapy based on targeting of cytotoxic peptide conjugates to their receptors on tumors

1999 • 275 citations

Somatostatin and the immune and haematopoetic system; a review

1994 • 162 citations

Cancer mortality in Europe, 1990–1994, and an overview of trends from 1955 to 1994

1999 • 153 citations

Synthesis and biological evaluation of cytotoxic analogs of somatostatin containing doxorubicin or its intensely potent derivative, 2-pyrrolinodoxorubicin

1998 • 143 citations

Somatostatin controls Kaposi's sarcoma tumor growth through inhibition of angiogenesis

1999 • 116 citations

Somatostatin receptors are present in small‐cell but not in non‐small‐cell primary lung carcinomas: Relationship to EGF‐receptors

1990 • 104 citations

Expression of somatostatin receptors in peritumoral veins of human tumors

1999 • 103 citations

The value of octreotide scintigraphy in patients with lung cancer

1994 • 101 citations

High yield conversion of doxorubicin to 2-pyrrolinodoxorubicin, an analog 500-1000 times more potent: structure-activity relationship of daunosamine-modified derivatives of doxorubicin.

1996 • 92 citations

Stability of cytotoxic luteinizing hormone-releasing hormone conjugate (AN-152) containing doxorubicin 14- O -hemiglutarate in mouse and human serum in vitro: Implications for the design of preclinical studies

2000 • 86 citations

Inhibition of PC-3 human androgen-independent prostate cancer and its metastases by cytotoxic somatostatin analogue AN-238.

1999 • 78 citations

Experimental and clinical studies with somatostatin analogue octreotide in small cell lung cancer

1991 • 75 citations

Somatostatin receptor subtypes sst1 and sst2 elicit opposite effects on the response to glutamate of mouse hypothalamic neurones: an electrophysiological and single cell RT‐PCR study

1998 • 60 citations

Apoptosis Versus Necrosis

1999 • 60 citations

Targeted cytotoxic analogue of somatostatin AN-238 inhibits growth of androgen-independent Dunning R-3327-AT-1 prostate cancer in rats at nontoxic doses.

1998 • 57 citations

Somatostatin receptor subtype gene expression in human and rodent tumors

1993 • 52 citations

Inhibition of growth of MX-1, MCF-7-MIII and MDA-MB-231 human breast cancer xenografts after administration of a targeted cytotoxic analog of somatostatin, AN-238

1999 • 47 citations

Inhibition of metastatic renal cell carcinomas expressing somatostatin receptors by a targeted cytotoxic analogue of somatostatin AN-238.

2000 • 46 citations

Improved silver technique for showing nucleolar organiser regions in paraffin wax sections.

1989 • 46 citations

Somatostatin receptor expression in lung cancer

1994 • 46 citations

Insulin secretion is inhibited by subtype five somatostatin receptor in the mouse

1998 • 44 citations

Small Cell Lung Cancer

1995 • 43 citations

Identification of somatostatin receptors in human small cell lung carcinoma

1990 • 42 citations

Regression of U-87 MG human glioblastomas in nude mice after treatment with a cytotoxic somatostatin analog AN-238.

2000 • 42 citations

Production of gastrin-releasing peptide by a non-small cell lung carcinoma cell line adapted to serum-free and growth factor-free conditions.

1994 • 42 citations

Expression of Somatostatin Receptor (SSTR) Subtypes in Pituitary Adenomas: Quantitative Analysis of SSTR2 mRNA by Reverse Transcription‐Polymerase Chain Reaction

1996 • 41 citations

RAPID COMMUNICATION: Human Ovarian Cancers Express Somatostatin Receptors

2000 • 38 citations

Effects of somatostatin analogue RC-160 and bombesin/gastrin-releasing peptide antagonists on the growth of human small-cell and non-small-cell lung carcinomas in nude mice

1994 • 31 citations

Growth inhibition of estrogen independent MXT mouse mammary carcinomas in mice treated with an agonist or antagonist of LH-RH, an analog of somatostatin, or a combination

1992 • 27 citations

Decrease in the AgNOR number in Dunning R3327 prostate cancers after treatment with an agonist and antagonist of luteinizing hormone-releasing hormone.

1991 • 24 citations

Quantitation of Mouse and Rat β-Actin mRNA by Competitive Polymerase Chain Reaction Using Capillary Electrophoresis

1997 • 17 citations

Apoptosis Versus Necrosis: Which Should Be the Aim of Cancer Therapy?

1999 • 16 citations

Localization of Small‐cell Lung Cancer Xenografts with Iodine‐125‐, Indium‐111‐, and Rhenium‐188‐Somatostatin Analogs

1996 • 15 citations

Imaging of Non–Small-Cell Lung Cancer With Indium-111 Pentetreotide

2000 • 13 citations