Specific Interaction of Angiostatin with Integrin αvβ3 in Endothelial Cells

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

The Biology of Vascular Endothelial Growth Factor

1997 • 4,359 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

1994 • 3,016 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

Angiostatin induces and sustains dormancy of human primary tumors in mice

1996 • 1,193 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

The role of αv integrins during angiogenesis: insights into potential mechanisms of action and clinical development

1999 • 651 citations

Disruption of Angiogenesis by PEX, a Noncatalytic Metalloproteinase Fragment with Integrin Binding Activity

1998 • 618 citations

A new murine monoclonal antibody reports an activation-dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complex.

1985 • 593 citations

Role of cell-surface lysines in plasminogen binding to cells: identification of .alpha.-enolase as a candidate plasminogen receptor

1991 • 544 citations

Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma

1991 • 523 citations

Angiostatin binds ATP synthase on the surface of human endothelial cells

1999 • 520 citations

Canstatin, a Novel Matrix-derived Inhibitor of Angiogenesis and Tumor Growth

2000 • 461 citations

Interaction of endostatin with integrins implicated in angiogenesis

2001 • 442 citations

The cell biology of the plasminogen system

1995 • 424 citations

Integrin αvβ3 Requirement for Sustained Mitogen-activated Protein Kinase Activity during Angiogenesis

1998 • 397 citations

Elevated matrix metalloprotease and angiostatin levels in integrin α1 knockout mice cause reduced tumor vascularization

2000 • 388 citations

Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis.

1996 • 385 citations

The alpha 1/beta 1 and alpha 6/beta 1 integrin heterodimers mediate cell attachment to distinct sites on laminin.

1990 • 375 citations

Kringle Domains of Human Angiostatin

1996 • 366 citations

Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD

1998 • 349 citations

An endothelial cell receptor for plasminogen/tissue plasminogen activator (t-PA). II. Annexin II-mediated enhancement of t-PA-dependent plasminogen activation.

1994 • 341 citations

The 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis.

1993 • 321 citations

New Functions for Non-collagenous Domains of Human Collagen Type IV

2000 • 308 citations

The Role of an Enolase‐Related Molecule in Plasminogen Binding to Cells

1995 • 252 citations

The properdin-like type I repeats of human thrombospondin contain a cell attachment site.

1991 • 238 citations

Two RGD-independent αvβ3 Integrin Binding Sites on Tumstatin Regulate Distinct Anti-tumor Properties

2000 • 229 citations

Identification of the Anti-angiogenic Site within Vascular Basement Membrane-derived Tumstatin

2001 • 226 citations

Angiogenesis Inhibitors Generated by Tumors

1995 • 214 citations

Specific Interaction of the Recombinant Disintegrin-like Domain of MDC-15 (Metargidin, ADAM-15) with Integrin αvβ3

1998 • 214 citations

RGD-independent Binding of Integrin α9β1 to the ADAM-12 and -15 Disintegrin Domains Mediates Cell-Cell Interaction

2000 • 211 citations

Identification of a regulatory region of integrin beta 1 subunit using activating and inhibiting antibodies

1993 • 206 citations

The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin.

1994 • 200 citations

Suppression of angiogenesis and tumor growth by the inhibitor K1–5 generated by plasmin-mediated proteolysis

1999 • 186 citations

A potent inhibitor of endothelial cell proliferation is generated by proteolytic cleavage of the chemokine platelet factor 4.

1995 • 143 citations

Role of integrin alpha(v)beta3 in vascular biology.

1998 • 141 citations

Requirement for VLA-4 and VLA-5 integrins in lymphoma cells binding to and migration beneath stromal cells in culture.

1992 • 137 citations

Role of Integrin αvβ3 in Vascular Biology

1998 • 136 citations

Characterization of kringle domains of angiostatin as antagonists of endothelial cell migration, an important process in angiogenesis

1998 • 131 citations

Identification of putative ligand-binding sites of the integrin α4β1 (VLA-4, CD49d/CD29)

1995 • 128 citations

Changing Ligand Specificities of αvβ1 and αvβ3 Integrins by Swapping a Short Diverse Sequence of the β Subunit

1997 • 116 citations

Critical amino acid residues for ligand binding are clustered in a predicted beta-turn of the third N-terminal repeat in the integrin alpha 4 and alpha 5 subunits.

1995 • 109 citations

Multiple Discontinuous Ligand-mimetic Antibody Binding Sites Define a Ligand Binding Pocket in Integrin αIIbβ3

2000 • 97 citations

Differential regulation of airway epithelial integrins by growth factors.

1996 • 97 citations

Human Parechovirus 1 Utilizes Integrins αvβ3 and αvβ1 as Receptors

2000 • 93 citations

Identification of Amino Acid Sequences in Fibrinogen γ-Chain and Tenascin C C-terminal Domains Critical for Binding to Integrin αvβ3

2000 • 87 citations

Critical Residues for Ligand Binding in an I Domain-like Structure of the Integrin β1 Subunit

1996 • 85 citations

Specific Binding of Integrin αvβ3 to the Fibrinogen γ and α_E Chain C-Terminal Domains

1999 • 85 citations

Identification of CD47/integrin-associated protein and alpha(v)beta3 as two receptors for the alpha3(IV) chain of type IV collagen on tumor cells.

1999 • 82 citations

Processing of chromogranin A by plasmin provides a novel mechanism for regulating catecholamine secretion

2000 • 80 citations

Binding of the NG2 Proteoglycan to Kringle Domains Modulates the Functional Properties of Angiostatin and Plasmin(ogen)

2000 • 69 citations

Purification, Cloning, and Characterization of a Profibrinolytic Plasminogen-binding Protein, TIP49a

2001 • 65 citations

Mutation of tyrosine-141 inhibits insulin-promoted tyrosine phosphorylation and increased responsiveness of the human beta 2-adrenergic receptor.

1995 • 59 citations

The Tumor-Suppressing Activity of Angiostatin Protein Resides within Kringles 1 to 3

1999 • 48 citations

β₁Integrin Activation Inhibitsin VitroTube Formation: Effects on Cell Migration, Vacuole Coalescence and Lumen Formation

1999 • 35 citations

Overexpressed α3β1 and Constitutively Activated Extracellular Signal-regulated Kinase Modulate the Angiogenic Properties of ECV304 Cells

1999 • 15 citations