Plasmin-induced Migration Requires Signaling through Protease-activated Receptor 1 and Integrin α9β1

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Angiostatin binds ATP synthase on the surface of human endothelial cells

1999 • 520 citations

Tumstatin, an Endothelial Cell-Specific Inhibitor of Protein Synthesis

2002 • 434 citations

Thrombin receptor overexpression in malignant and physiological invasion processes

1998 • 408 citations

Elevated matrix metalloprotease and angiostatin levels in integrin α1 knockout mice cause reduced tumor vascularization

2000 • 388 citations

Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor

2001 • 301 citations

Biphasic Kinetics of Activation and Signaling for PAR1 and PAR4 Thrombin Receptors in Platelets

2000 • 296 citations

The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin

1997 • 292 citations

Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation

2002 • 267 citations

The Integrin α9β1 Mediates Adhesion to Activated Endothelial Cells and Transendothelial Neutrophil Migration through Interaction with Vascular Cell Adhesion Molecule-1

1999 • 258 citations

Elements of the Fibrinolytic System

2001 • 253 citations

Osteopontin N-terminal Domain Contains a Cryptic Adhesive Sequence Recognized by α9β1 Integrin

1996 • 246 citations

The properdin-like type I repeats of human thrombospondin contain a cell attachment site.

1991 • 238 citations

Identification of the Anti-angiogenic Site within Vascular Basement Membrane-derived Tumstatin

2001 • 226 citations

Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle [published erratum appears in J Cell Biol 1994 Feb;124(3):395]

1993 • 221 citations

Specific Interaction of the Recombinant Disintegrin-like Domain of MDC-15 (Metargidin, ADAM-15) with Integrin αvβ3

1998 • 214 citations

Evidence of involvement of CD44 in endothelial cell proliferation, migration and angiogenesisin vitro

1996 • 214 citations

RGD-independent Binding of Integrin α9β1 to the ADAM-12 and -15 Disintegrin Domains Mediates Cell-Cell Interaction

2000 • 211 citations

Identification of a regulatory region of integrin beta 1 subunit using activating and inhibiting antibodies

1993 • 206 citations

The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin.

1994 • 200 citations

Specific Interaction of Angiostatin with Integrin αvβ3 in Endothelial Cells

2001 • 196 citations

Deregulation of the signaling pathways controlling urokinase production

1999 • 189 citations

Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1

2001 • 185 citations

Development and Disease in Proteinase-Deficient Mice

1998 • 177 citations

Functional Classification of ADAMs Based on a Conserved Motif for Binding to Integrin α9β1

2002 • 159 citations

Plasmin inhibition of platelet function and of arachidonic acid metabolism.

1985 • 149 citations

Tumor Cell Invasion Is Promoted by Activation of Protease Activated Receptor-1 in Cooperation with the αvβ5 Integrin

2001 • 137 citations

Characterization of kringle domains of angiostatin as antagonists of endothelial cell migration, an important process in angiogenesis

1998 • 131 citations

Plasmin-induced Migration of Endothelial Cells

2002 • 130 citations

Platelet protein phosphorylation, elevation of cytosolic calcium, and inositol phospholipid breakdown in platelet activation induced by plasmin.

1986 • 124 citations

Gene and Locus Structure and Chromosomal Localization of the Protease-activated Receptor Gene Family

1998 • 109 citations

Plasmin Is a Potent and Specific Chemoattractant for Human Peripheral Monocytes Acting Via a Cyclic Guanosine Monophosphate–Dependent Pathway

1997 • 107 citations

Differential regulation of airway epithelial integrins by growth factors.

1996 • 97 citations

Plasmin Induces Cyr61 Gene Expression in Fibroblasts Via Protease-Activated Receptor-1 and p44/42 Mitogen-Activated Protein Kinase–Dependent Signaling Pathway

2002 • 82 citations

Discovery and Optimization of a Novel Series of Thrombin Receptor (PAR-1) Antagonists: Potent, Selective Peptide Mimetics Based on Indole and Indazole Templates

2001 • 75 citations

The Cytoplasmic Domain of the Integrin α9 Subunit Requires the Adaptor Protein Paxillin to Inhibit Cell Spreading but Promotes Cell Migration in a Paxillin-independent Manner

2001 • 74 citations

Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human airways.

1995 • 73 citations

α9β1 Integrin is expressed on human neutrophils and contributes to neutrophil migration through human lung and synovial fibroblast barriers

1999 • 69 citations

Post-translational and Activation-dependent Modifications of the G Protein-coupled Thrombin Receptor

1995 • 63 citations

Dynamic Changes in Intracellular Localization and Isoforms of the 27-kD Stress Protein in Human Keratinocytes

1994 • 63 citations

Plasmin-platelet interaction involves cleavage of functional thrombin receptor

1996 • 62 citations

Human plasmin induces a receptor-mediated arachidonate release coupled with G proteins in endothelial cells

1993 • 59 citations

Endogenous Angiogenesis Inhibitors: Angiostatin, Endostatin, and Other Proteolytic Fragments

1998 • 51 citations

Mapping of the Cryptic Integrin-Binding Site in Osteopontin Suggests a New Mechanism by Which Thrombin Can Regulate Inflammation and Tissue Repair

2000 • 41 citations

Plasmin Is a Specific Stimulus of the 5-Lipoxygenase Pathway of Human Peripheral Monocytes

1996 • 40 citations

An Assay for High-Sensitivity Detection of Thrombin Activity and Determination of Proteases Activating or Inactivating Protease-Activated Receptors

2000 • 27 citations

Reciprocal Functions of Liver Tumor Cells and Endothelial Cells

2000 • 6 citations