Expression of Vascular Endothelial Growth Factor Receptors 1, 2, and 3 in Quiescent Endothelia

Angiogenesis in cancer and other diseases

2000 • 8,734 citations

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Vascular-specific growth factors and blood vessel formation

2000 • 3,667 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.

1996 • 1,670 citations

Molecular and Biological Properties of the Vascular Endothelial Growth Factor Family of Proteins

1992 • 1,612 citations

Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1

1996 • 1,355 citations

Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer.

1995 • 1,271 citations

Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)

1998 • 1,192 citations

Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation

1992 • 1,103 citations

Inhibition of VEGF receptors causes lung cell apoptosis and emphysema

2000 • 1,099 citations

SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types.

1999 • 1,044 citations

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration

2001 • 1,012 citations

VEGF is required for growth and survival in neonatal mice

1999 • 901 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor and the Significance of Microvascular Hyperpermeability in Angiogenesis

1999 • 752 citations

Regulation of angiogenesis via vascular endothelial growth factor receptors.

2000 • 749 citations

Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis.

1995 • 699 citations

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract.

1993 • 645 citations

Vascular endothelial growth factor is essential for corpus luteum angiogenesis

1998 • 641 citations

Vascular Endothelial Growth Factor Induces Endothelial Fenestrations In Vitro

1998 • 638 citations

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer

1995 • 622 citations

Control of hair growth and follicle size by VEGF-mediated angiogenesis

2001 • 603 citations

Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas.

1993 • 564 citations

Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells

1998 • 551 citations

Vascular Endothelial Growth Factor: Molecular and Biological Aspects

1999 • 542 citations

Endothelial receptor tyrosine kinases involved in angiogenesis.

1995 • 537 citations

Polarized Vascular Endothelial Growth Factor Secretion by Human Retinal Pigment Epithelium and Localization of Vascular Endothelial Growth Factor Receptors on the Inner Choriocapillaris

1999 • 502 citations

SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.

2000 • 501 citations

RPE destruction causes choriocapillary atrophy.

1984 • 371 citations

Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues

1993 • 369 citations

Vascular Endothelial Growth Factor-C (VEGF-C/VEGF-2) Promotes Angiogenesis in the Setting of Tissue Ischemia

1998 • 353 citations

VEGF‐C and VEGF‐D expression in neuroendocrine cells and their receptor, VEGFR‐3, in fenestrated blood vessels in human tissues

2000 • 343 citations

Characterization of the receptors for vascular endothelial growth factor.

1990 • 310 citations

Expression of vascular endothelial growth factors A, B, C, and D and their relationships to lymph node status in lung adenocarcinoma.

2000 • 288 citations

Expression of vascular endothelial growth factor and its receptors in human renal ontogenesis and in adult kidney

1995 • 287 citations

Expression of vascular endothelial growth factor in digestive neuroendocrine tumours

1998 • 271 citations

Monoclonal antibody PAL-E specific for endothelium.

1985 • 251 citations

Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis

2001 • 240 citations

Differential expression of markers for endothelial cells, pericytes, and basal lamina in the microvasculature of tumors and granulation tissue.

1991 • 222 citations

Release and Complex Formation of Soluble VEGFR-1 from Endothelial Cells and Biological Fluids

2000 • 217 citations

Regulation of angiogenesis in the endometrium

2001 • 211 citations

Expression of the Vascular Endothelial Growth Factor C Receptor VEGFR-3 in Lymphatic Endothelium of the Skin and in Vascular Tumors

1998 • 206 citations

Expression of endothelial cell-specific receptor tyrosine kinases and growth factors in human brain tumors.

1995 • 205 citations

Leukocyte antigen CD34 is expressed by a subset of cultured endothelial cells and on endothelial abluminal microprocesses in the tumor stroma.

1990 • 197 citations

In the human fetus, vascular endothelial growth factor is expressed in epithelial cells and myocytes, but not vascular endothelium: implications for mode of action.

1994 • 196 citations

Up-regulation of flk-1/vascular endothelial growth factor receptor 2 by its ligand in a cerebral slice culture system.

1997 • 195 citations

Expression of vascular endothelial growth factor in lymphomas and castleman's disease

1997 • 179 citations

VEGFR‐3 in adult angiogenesis

2001 • 159 citations

VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis

2000 • 155 citations

Nonvascular role for vascular endothelial growth factor (VEGF): VEGFR‐1 and VEGFR‐2 activity is critical for neural retinal development

2001 • 147 citations

Receptors of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in fetal and adult human kidney

1998 • 142 citations

VEGF Regulates Cell Behavior during Vasculogenesis

2000 • 129 citations

Vascular growth factors and receptors in capillary hemangioblastomas and hemangiopericytomas.

1996 • 123 citations

Ultrastructural Localization of the Vascular Permeability Factor/Vascular Endothelial Growth Factor (VPF/VEGF) Receptor-2 (FLK-1, KDR) in Normal Mouse Kidney and in the Hyperpermeable Vessels Induced by VPF/VEGF-expressing Tumors and Adenoviral Vectors

2000 • 119 citations

Ultrastructural localization of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) to the abluminal plasma membrane and vesiculovacuolar organelles of tumor microvascular endothelium.

1995 • 118 citations

Altered expression patterns of VEGF receptors in human diabetic retina and in experimental VEGF-induced retinopathy in monkey.

2002 • 112 citations

Identification and Characterization of Vascular Endothelial Growth Factor Receptor (Flt) in Bovine Retinal Pericytes

1996 • 107 citations

Signal relays in the VEGF system

1999 • 98 citations

Expression of vascular endothelial growth factor (VEGF) in various compartments of the human hair follicle

1998 • 97 citations

Signal relays in the VEGF system

1999 • 82 citations

Increased Expression of Vascular Endothelial Growth Factor (VEGF) in Castleman's Disease: Proposed Pathomechanism of Vascular Proliferation in the Affected Lymph Node

2000 • 64 citations

Time-course expression of vascular endothelial growth factor as related to the development of the retinochoroidal vasculature in rats

1998 • 59 citations

Functions of the VEGF/VEGF Receptor System in the Vascular System

2000 • 57 citations

Monoclonal Antibody-Defined Human Endothelial Antigens as Vascular Markers

1989 • 50 citations

Systemic activation of the vascular endothelial growth factor receptor KDR/flk-1 selectively triggers endothelial cells with an angiogenic phenotype.

1997 • 42 citations

Vascular Expression of Endothelial Antigen PAL-E Indicates Absence of Blood-Ocular Barriers in the Normal Eye

1997 • 37 citations