Nitric Oxide in Inflammation and Immune Response

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

Nitric oxide synthases in mammals

1994 • 2,762 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

Nitric oxide activates cyclooxygenase enzymes.

1993 • 1,416 citations

L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation

1988 • 1,379 citations

Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.

1992 • 1,237 citations

An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.

1990 • 1,209 citations

Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical.

1987 • 1,182 citations

Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene

1993 • 881 citations

Inflammation, immunoregulation, and inducible nitric oxide synthase

1993 • 877 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

Nitric oxide: mediator, murderer, and medicine

1994 • 836 citations

Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine.

1993 • 832 citations

Isoforms of nitric oxide synthase Characterization and purification from different cell types

1991 • 827 citations

Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase

1993 • 825 citations

Biological Roles of Nitric Oxide

1992 • 731 citations

Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases.

1992 • 728 citations

Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase.

1992 • 712 citations

Suppression of arthritis by an inhibitor of nitric oxide synthase.

1993 • 662 citations

The 1991 Ulf von Euler Lecture:The <scp>l</scp>‐arginine: nitric oxide pathway

1992 • 654 citations

Nitrogen Oxide Levels in Patients After Trauma and During Sepsis

1991 • 609 citations

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.

1988 • 592 citations

Modulation of acute inflammation by endogenous nitric oxide

1992 • 543 citations

Signal transduction mechanisms involving nitric oxide

1991 • 538 citations

Synthesis of nitric oxide from <scp>l</scp>-arginine by neutrophils. Release and interaction with superoxide anion

1989 • 529 citations

Effects of a nitric oxide synthase inhibitor in humans with septic shock

1994 • 521 citations

Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.

1992 • 494 citations

Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium.

1993 • 490 citations

The Molecule of the Year

1989 • 489 citations

Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide.

1991 • 448 citations

The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine.

1994 • 447 citations

Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide.

1991 • 436 citations

The Molecule of the Year

1992 • 411 citations

Feedback inhibition of nitric oxide synthase activity by nitric oxide

1993 • 396 citations

Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation.

1992 • 390 citations

Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat

1990 • 389 citations

Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role of IFN-gamma in the induction of the nitric oxide-synthesizing pathway.

1991 • 384 citations

Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells

1994 • 377 citations

Nitric-Oxide Mediates Suppression of Cartilage Proteoglycan Synthesis by Interleukin-1

1994 • 374 citations

Inhibition of Cytochromes P450 by Nitric Oxide and a Nitric Oxide-Releasing Agent

1993 • 358 citations

Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds.

1993 • 353 citations

The Role of T _H 1 and T _H 2 Cells in a Rodent Malaria Infection

1993 • 352 citations

Molecular basis of "suppressor" macrophages. Arginine metabolism via the nitric oxide synthetase pathway.

1991 • 344 citations

Nitric Oxide Synthase Is Not a Constituent of the Antimicrobial Armature of Human Mononuclear Phagocytes

1993 • 334 citations

Nitric oxide and prostacyclin. Divergence of inhibitory effects on monocyte chemotaxis and adhesion to endothelium in vitro.

1991 • 331 citations

Modulation of adjuvant arthritis by endogenous nitric oxide

1993 • 316 citations

Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor.

1989 • 311 citations

Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte.

1993 • 302 citations

Nitric oxide and arthritis

1993 • 299 citations

Generation of nitric oxide by human neutrophils

1989 • 298 citations

Interleukin‐13 alters the activation state of murine macrophages in vitro: Comparison with interleukin‐4 and interferon‐γ

1994 • 298 citations

Dependence of the metabolism of nitric oxide (NO) in healthy human whole blood on the oxygenation of its red cell haemoglobin

1992 • 294 citations

Induction of Nitric Oxide Synthase in Human Chondrocytes

1993 • 286 citations

Alterations of ribonucleotide reductase activity following induction of the nitrite-generating pathway in adenocarcinoma cells.

1990 • 284 citations

Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion of dogs.

1993 • 274 citations

Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion.

1991 • 257 citations

Nitric oxide, an inhibitor of lipid oxidation by lipoxygenase, cyclooxygenase and hemoglobin

1992 • 254 citations

Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from L-arginine

1992 • 254 citations

IL-1.beta. induces the coexpression of both nitric oxide synthase and cyclooxygenase by Islets of Langerhans: activation of cyclooxygenase by nitric oxide

1993 • 253 citations

Formation and release of nitric oxide from human neutrophils and HL‐60 cells induced by a chemotactic peptide, platelet activating factor and leukotriene B₄

1989 • 244 citations

N‐Monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats

1994 • 213 citations

Mammalian nitrate biosynthesis: incorporation of 15NH3 into nitrate is enhanced by endotoxin treatment.

1983 • 211 citations

Induction of nitric oxide synthase protects against malaria in mice exposed to irradiated Plasmodium berghei infected mosquitoes: involvement of interferon gamma and CD8+ T cells.

1994 • 211 citations

Time course and mechanism of endothelial dysfunction in isolated ischemic- and hypoxic-perfused rat hearts

1990 • 204 citations

NITRIC OXIDE—A NEW ENDOGENOUS IMMUNOMODULATOR

1993 • 198 citations

Evidence for reactive nitrogen intermediates in killing of staphylococci by human neutrophil cytoplasts. A new microbicidal pathway for polymorphonuclear leukocytes.

1992 • 186 citations

Nitric oxide production in host-versus-graft and graft-versus-host reactions in the rat.

1992 • 179 citations

Nitric oxide signaling: a possible role for G proteins.

1993 • 175 citations

Nitric oxide involvement in tumor-induced immunosuppression.

1994 • 171 citations

Inhibition by nitric oxide‐donors of human polymorphonuclear leucocyte functions

1993 • 161 citations

Induction of nitric oxide synthase in rat peritoneal neutrophils and its inhibition by dexamethasone

1991 • 161 citations

The protective role of endogenously synthesized nitric oxide in staphylococcal enterotoxin B-induced shock in mice.

1994 • 156 citations

Role of nitric oxide in eicosanoid synthesis and uterine motility in estrogen-treated rat uteri.

1994 • 152 citations

Nitric oxide and cyclic GMP formation induced by interleukin 1β in islets of Langerhans. Evidence for an effector role of nitric oxide in islet dysfunction

1992 • 140 citations

Time‐dependent enhancement or inhibition of endotoxin‐induced vascular injury in rat intestine by nitric oxide synthase inhibitors

1994 • 137 citations

Nitric oxide and human skin blood flow responses to acetylcholine and ultraviolet light

1994 • 135 citations

Nitric oxide regulates endotoxin-induced TNF-alpha production by human neutrophils.

1994 • 134 citations

Reactive nitrogen intermediates suppress the primary immunologic response to Listeria.

1993 • 130 citations

Increased Circulating Nitrogen Oxides After Human Tumor Immunotherapy: Correlation With Toxic Hemodynamic Changes

1992 • 129 citations

Nitric Oxide Mediates Interleukin-1-Induced Prostaglandin E2 Production by Vascular Smooth Muscle Cells

1993 • 128 citations

Depletion of gamma interferon and tumor necrosis factor alpha in mice with Rickettsia conorii-infected endothelium: impairment of rickettsicidal nitric oxide production resulting in fatal, overwhelming rickettsial disease

1994 • 127 citations

Differential mechanisms of intracellular killing ofMycobacterium aviumandListeria monocytogenesby activated human and murine macrophages. The role of nitric oxide

1993 • 122 citations

Vimentin is transiently co-localized with and phosphorylated by cyclic GMP-dependent protein kinase in formyl-peptide-stimulated neutrophils.

1991 • 118 citations

Role of prostaglandins and nitric oxide in acute inflammatory reactions in guinea‐pig skin

1993 • 107 citations

Nitric oxide mediates intestinal pathology in graft-vs.-host disease

1992 • 103 citations

Inhibitors of nitric oxide synthase attenuate human neutrophil chemotaxis in vitro.

1993 • 100 citations

EDRF increases cyclic GMP in platelets during passage through the coronary vascular bed.

1989 • 98 citations

Mechanisms of vasodilatation

1980 • 90 citations

Glucocorticoids do not affect the induction of a novel calcium-dependent nitric oxide synthase in rabbit chondrocytes

1992 • 80 citations

Identification of cytosolic peroxisome proliferator binding protein as a member of the heat shock protein HSP70 family.

1990 • 79 citations

The inducible production of nitric oxide by articular cell types

1994 • 77 citations

Nitric oxide mediates interleukin‐1 induced inhibition of glycosaminoglycan synthesis in rat articular cartilage

1995 • 77 citations

Rapid Induction of Messenger RNA for Nitric Oxide Synthase II in Rat Neutrophils In Vivo by Endotoxin and its Suppression by Prednisolone

1994 • 75 citations

Involvement of Fcε:RII/CD23 and L-argininedependent pathway in IgE-mediated stimulation of human monocyte functions

1994 • 68 citations

Nitric Oxide Stimulates the ADP-Ribosylation of Actin in Human Neutrophils

1993 • 68 citations

Exogenous nitric oxide (NO) generation or IL-1 beta-induced intracellular NO production stimulates inhibitory auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase in RINm5F cells.

1993 • 66 citations

Cyclic GMP mediates SIN-1-induced inhibition of human polymorphonuclear leukocytes

1990 • 60 citations

Mechanisms of Vasodilatation

1986 • 59 citations

Nitric oxide and superoxide radical are involved in both initiation and development of adjuvant arthritis in rats

1994 • 55 citations

Regulation of human neutrophil degranulation by LY-83583 and L-arginine: role of cGMP-dependent protein kinase

1993 • 53 citations

Modulation of human t cell responses by nitric oxide and its derivative, s‐nitrosoglutathione

1993 • 51 citations

Nitric Oxide Production by Human Peripheral Blood Polymorphonuclear Leucocytes

1994 • 45 citations

Stimulatory and inhibitory action of nitric oxide donor agents vs. nitrovasodilators on reactive oxygen production by isolated polymorphonuclear leukocytes.

1994 • 45 citations

Co-purification of 130 KD nitric oxide synthase and A 22 KD link protein from human neutrophils

1992 • 44 citations

Comparative platelet inhibitory effects of human neutrophils and lymphocytes.

1990 • 38 citations

Feedback suppression of staphylococcal enterotoxin-stimulated T-lymphocyte proliferation by macrophages through inductive nitric oxide synthesis

1992 • 37 citations

Platelet aggregation is inhibited by a nitric oxide-like factor released from human neutrophils in vitro

2008 • 35 citations

Nitrovasodilator-induced inhibition of LTB4 release from human PMN may be mediated by cyclic GMP.

1990 • 35 citations

NITRIC OXIDE PRODUCTION BY MOUSE SPONGE MATRIX ALLOGRAFT-INFILTRATING CELLS COMPARISON WITH THE RAT SPECIES

1993 • 26 citations

Expression of cellular effector functions and production of reactive nitrogen intermediates: A comparative study including T lymphocytes, T-like cells, neutrophil granulocytes, and mononuclear phagocytes

1990 • 25 citations

The effects of the nitric oxide donors molsidomine and SIN-1 on human polymorphonuclear leucocyte functionin vitro andex vivo

1992 • 19 citations

The Effects of Nitric Oxide on Chondrocytes and Lymphocytes

1993 • 9 citations

Inhibition by a stable factor derived from neutrophils of endothelium-dependent relaxation in rat aorta

1993 • 7 citations

Efffects of NO-Donors, SIN-1 and GEA 3175 on Prostacyclin and cGMP Synthesis in Cultured Rat Endothelial Cells

1995 • 7 citations

Exogenous Modification of Nitrovasodilator‐Induced Cyclic GMP Formation in Human Lymphocytes

1992 • 5 citations