Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

The T Lymphocyte in Experimental Allergic Encephalomyelitis

1990 • 1,005 citations

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

1992 • 877 citations

IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.

1992 • 709 citations

γ Interferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites

1987 • 699 citations

Widespread tissue distribution, species distribution and changes in activity of Ca²⁺‐dependent and Ca²⁺‐independent nitric oxide synthases

1991 • 645 citations

Interferon‐γ and tumor necrosis factor induce the L‐arginine‐dependent cytotoxic effector mechanism in murine macrophages^*

1988 • 511 citations

Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus.

1988 • 462 citations

Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype

1989 • 390 citations

Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages

1992 • 384 citations

The Role of T _H 1 and T _H 2 Cells in a Rodent Malaria Infection

1993 • 352 citations

Cytokine-Induced Synthesis of Nitrogen Oxides in Macrophages: A Protective Host Response to Leishmania and Other Intracellular Pathogens

1991 • 267 citations

A possible novel pathway of regulation by murine T helper type‐2 (T_h2) cells of a T_h1 cell activity via the modulation of the induction of nitric oxide synthase on macrophages

1991 • 226 citations

Possible central role of nitric oxide in conditions clinically similar to cerebral malaria

1992 • 140 citations

Inhibitory activity of interferons and interleukin 1 on the development of Plasmodium falciparum in human hepatocyte cultures.

1987 • 112 citations

The role of nitrogen oxides as effector molecules of parasite killing

1990 • 72 citations

Functional characterization of protective CD4+ T-cell clones reactive to the murine malaria parasite Plasmodium chabaudi.

1992 • 59 citations

T-cell subsets in autoimmunity

1992 • 49 citations

T_h1 and T_h2 CD4⁺ T cell clones specific for Plasmodium chabaudi but not for an unrelated antigen protect against blood stage P. chabaudi infection

1994 • 41 citations

Inhibition of pathogenic effect of effector T cells by specific suppressor T cells during influenza virus infection in mice

1983 • 41 citations