Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation

Integrins

2002 • 8,127 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

Regulation of Cell Motility by Mitogen-activated Protein Kinase

1997 • 1,238 citations

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.

1995 • 1,202 citations

Autophosphorylation of the Focal Adhesion Kinase, ppl25^FAK, Directs SH2-Dependent Binding of pp60^src

1994 • 1,168 citations

IL-1 is required for tumor invasiveness and angiogenesis

2003 • 986 citations

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

1999 • 970 citations

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.

1995 • 620 citations

Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation.

1996 • 514 citations

Integrins and cell proliferation

2001 • 509 citations

A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK

1996 • 488 citations

Imatinib mesylate blocks a non‐Smad TGF‐β pathway and reduces renal fibrogenesis in vivo

2005 • 452 citations

Targeted disruption of β1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction

2004 • 402 citations

Focal Adhesion Kinase Overexpression Enhances Ras-dependent Integrin Signaling to ERK2/Mitogen-activated Protein Kinase through Interactions with and Activation of c-Src

1997 • 380 citations

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.

1996 • 371 citations

Inhibition of Cell Spreading by Expression of the C-Terminal Domain of Focal Adhesion Kinase (FAK) Is Rescued by Coexpression of Src or Catalytically Inactive FAK: a Role for Paxillin Tyrosine Phosphorylation

1997 • 329 citations

Hypersialylation of β1 Integrins, Observed in Colon Adenocarcinoma, May Contribute to Cancer Progression by Up-regulating Cell Motility

2005 • 305 citations

Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells.

1996 • 265 citations

Focal Adhesion Kinase Mediates the Integrin Signaling Requirement for Growth Factor Activation of Map Kinase

1999 • 205 citations

PTEN Gene and Integrin Signaling in Cancer

1999 • 186 citations

Ras Activation Is Necessary for Integrin-mediated Activation of Extracellular Signal-regulated Kinase 2 and Cytosolic Phospholipase A2 but Not for Cytoskeletal Organization

1996 • 167 citations

Apoptosis detection: an overview

1998 • 165 citations

Focal Adhesion Kinase Suppresses Apoptosis by Binding to the Death Domain of Receptor-Interacting Protein

2004 • 165 citations

Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells

2004 • 153 citations

Interleukin-1 receptor blockade reduces the number and size of murine B16 melanoma hepatic metastases.

1994 • 145 citations

Interleukin-1 stimulates cytokines, prostaglandin E2 and matrix metalloproteinase-1 production via activation of MAPK/AP-1 and NF-κB in human gingival fibroblasts

2004 • 124 citations

Focal adhesion kinase is overexpressed in hepatocellular carcinoma and can be served as an independent prognostic factor

2004 • 102 citations

Nerve growth factor stimulates MMP-2 expression and activity and increases invasion by human pancreatic cancer cells

2004 • 96 citations

ROLE OF P38 MAPK, AP-1, AND NF-κB IN INTERLEUKIN-1β-INDUCED IL-8 EXPRESSION IN HUMAN VASCULAR SMOOTH MUSCLE CELLS

2002 • 93 citations

Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and Caveolin-1

2005 • 89 citations

Collagen IV-dependent ERK Activation in Human Caco-2 Intestinal Epithelial Cells Requires Focal Adhesion Kinase

2000 • 81 citations

Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR–β1 integrin complex in colon cancer cells

2003 • 77 citations

High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome

2005 • 75 citations

Integrin β1 is required for the invasive behaviour but not proliferation of squamous cell carcinoma cells in vivo

2004 • 66 citations

Butyrate downregulates alpha2beta1 integrin: a possible role in the induction of apoptosis in colorectal cancer cell lines

2003 • 65 citations

Pancreatic Stellate Cells (PSCs) express Cyclooxygenase-2 (COX-2) and pancreatic cancer stimulates COX-2 in PSCs

2005 • 64 citations

Human intestinal epithelial crypt cell survival and death: Complex modulations of Bcl‐2 homologs by Fak, PI3‐K/Akt‐1, MEK/Erk, and p38 signaling pathways

2003 • 62 citations

Recruitment of focal adhesion kinase and paxillin to β1 integrin promotes cancer cell migration via mitogen activated protein kinase activation

2004 • 60 citations

Perlecan Up-Regulation of FRNK Suppresses Smooth Muscle Cell Proliferation via Inhibition of FAK Signaling

2003 • 55 citations

Overexpression of RhoA-GTP induces activation of the Epidermal Growth Factor Receptor, dephosphorylation of focal adhesion kinase and increased motility in breast cancer cells

2005 • 54 citations

Interleukin-1α Enhances Integrin α<sub>6</sub>β<sub>1</sub> Expression and Metastatic Capability of Human Pancreatic Cancer

2003 • 53 citations

Integrin-Linked Kinase Mediates Bone Morphogenetic Protein 7-Dependent Renal Epithelial Cell Morphogenesis

2005 • 51 citations

Interleukin‐1β induces cyclo‐oxygenase‐2 expression in gastric cancer cells by the p38 and p44/42 mitogen‐activated protein kinase signaling pathways

2001 • 46 citations

Study of the PTEN gene expression and FAK phosphorylation in human hepatocarcinoma tissues and cell lines

2004 • 45 citations

N-Myc overexpression leads to decreased β1 integrin expression and increased apoptosis in human neuroblastoma cells

2003 • 42 citations

IL-1α gene-transfected human melanoma cells increase tumor-cell adhesion to endothelial cells and their retention in the lung of nude mice

1996 • 41 citations

Role of Raf-1 and FAK in cell density-dependent regulation of integrin-dependent activation of MAP kinase

2002 • 32 citations

Activation of focal adhesion kinase in human lung cancer cells involves multiple and potentially parallel signaling events

2005 • 29 citations

Formation of focal adhesion and spreading of polarized human colon cancer cells in association with tyrosine phosphorylation of paxillin in response to phorbol ester.

1996 • 29 citations

Expression and prognostic roles of integrins and interleukin-1 receptor type I in patients with ductal adenocarcinoma of the pancreas.

2003 • 28 citations

Epidermal growth factor mediates detachment from and invasion through collagen I and Matrigel in Capan-1 pancreatic cancer cells

2005 • 25 citations

A p130Cas tyrosine phosphorylated substrate domain decoy disrupts v-crk signaling.

2002 • 24 citations

Apoptosis of rat hepatic stellate cells induced by anti-focal adhesion kinase antibody

2002 • 22 citations

Rel/Nuclear factor-kappa B apoptosis pathways in human cervical cancer cells

2005 • 21 citations

Mitochondrial function is a critical determinant of IL‐1‐induced ERK activation

2005 • 17 citations

Type I IL-1 receptor: ligand specific conformation differences and the role of glycosylation in ligand binding

1996 • 12 citations

Loss of cellular adhesion to matrix induces p53-independent expression of PTEN tumor suppressor.

2002 • 5 citations