Interleukin‐1β induces cyclo‐oxygenase‐2 expression in gastric cancer cells by the p38 and p44/42 mitogen‐activated protein kinase signaling pathways

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Cytoprotection by prostaglandins in rats

1979 • 1,698 citations

cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.

1992 • 838 citations

Nonsteroidal Antiinflammatory Drugs — Differences and Similarities

1991 • 756 citations

Protein kinase cascades activated by stress and inflammatory cytokines

1996 • 722 citations

Expression of mRNA for cyclooxygenase‐1 and cyclooxygenase‐2 in human tissues

1993 • 708 citations

Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice

1997 • 662 citations

Mucosal Tumor Necrosis Factor-or, Interleukin-1/3, and Interleukin-8 Production in Patients with Helicobacter pylori Infection

1994 • 526 citations

Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa

1996 • 332 citations

Chemokines, inflammation and the immune system.

1994 • 302 citations

Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxyl-terminal region of the cyclooxygenase-2.

1993 • 293 citations

Effects of inhibition of prostaglandin endoperoxide synthase‐2 in chronic gastro‐intestinal ulcer models in rats

1998 • 293 citations

Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels.

1997 • 288 citations

Transcriptional Regulation of Prostaglandin Synthase 2 Gene Expression by Platelet-derived Growth Factor and Serum

1996 • 244 citations

Inhibitory effect of non-steroidal anti-inflammatory drugs on mucosal cell proliferation associated with gastric ulcer healing

1990 • 182 citations

p38 Mitogen-activated Protein Kinase Down-regulates Nitric Oxide and Up-regulates Prostaglandin E2 Biosynthesis Stimulated by Interleukin-1β

1997 • 181 citations

Delayed Healing of Acetic Acid-Induced Gastric Ulcers in Rats by Indomethacin

1989 • 166 citations

Yes, but do they still get headaches?

1995 • 155 citations

Ranitidine in the treatment of non-steroidal anti-inflammatory drug associated gastric and duodenal ulcers.

1991 • 149 citations

Pathogenesis of NSAID gastropathy: are neutrophils the culprits?

1992 • 134 citations

Role of cyclooxygenase-2 in the healing of gastric ulcers in rats.

1998 • 131 citations

ERK and p38 MAP Kinase Pathways Are Mediators of Intestinal Epithelial Wound-Induced Signal Transduction

1997 • 100 citations

Localization of cyclooxygenase-2 and regulation of its mRNA expression in gastric ulcers in rats

1998 • 99 citations

Induction of mitogen-activated protein kinase signal transduction pathway during gastric ulcer healing in rats

1998 • 96 citations

HGF triggers activation of the COX‐2 gene in rat gastric epithelial cells: action mediated through the ERK2 signaling pathway

1999 • 90 citations

Gene expression of keratinocyte and hepatocyte growth factors during the healing of rat gastric mucosal lesions

1995 • 84 citations

Effects of 16,16-Dimethyl Prostaglandin E2 on Ethanol-Induced and Aspirin-Induced Gastric Damage in the Rat

1985 • 74 citations

Influence of nonsteroidal anti-inflammatory compounds on healing of chronic gastric ulcers in rats

1982 • 23 citations

Induction of signal transduction pathways in rat gastric epithelial cells stimulated with interleukin-1β

2000 • 13 citations