Integrin-Linked Kinase Mediates Bone Morphogenetic Protein 7-Dependent Renal Epithelial Cell Morphogenesis

A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.

1995 • 1,118 citations

Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase

1996 • 1,106 citations

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

1998 • 1,097 citations

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.

1995 • 1,021 citations

Integrin-linked kinase: a cancer therapeutic target unique among its ILK

2005 • 593 citations

Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects inBMP7 deficient embryos

1997 • 448 citations

Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells

2000 • 430 citations

Integrin cytoplasmic interactions and bidirectional transmembrane signalling

1996 • 396 citations

Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation

2003 • 389 citations

Integrin α8β1 Is Critically Important for Epithelial–Mesenchymal Interactions during Kidney Morphogenesis

1997 • 359 citations

The LIM-Only Protein PINCH Directly Interacts with Integrin-Linked Kinase and Is Recruited to Integrin-Rich Sites in Spreading Cells

1999 • 300 citations

Regulation of tumor angiogenesis by integrin-linked kinase (ILK)

2004 • 261 citations

An osmotically tolerant inner medullary collecting duct cell line from an SV40 transgenic mouse

1993 • 260 citations

The Integrin-linked Kinase Regulates the Cyclin D1 Gene through Glycogen Synthase Kinase 3β and cAMP-responsive Element-binding Protein-dependent Pathways

2000 • 243 citations

Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling

1999 • 237 citations

Cell–substrate interactions and signaling through ILK

2000 • 228 citations

Nck-2, a Novel Src Homology2/3-containing Adaptor Protein That Interacts with the LIM-only Protein PINCH and Components of Growth Factor Receptor Kinase-signaling Pathways

1998 • 188 citations

Glypican-3 Modulates BMP- and FGF-Mediated Effects during Renal Branching Morphogenesis

2001 • 179 citations

Identification of Osteopontin as a Novel Ligand for the Integrin α8β1 and Potential Roles for This Integrin–Ligand Interaction in Kidney Morphogenesis

1998 • 177 citations

The role of integrin-linked kinase (ILK) in cancer progression.

2003 • 173 citations

Regulation of BMP7 expression during kidney development

1998 • 147 citations

BMP-2 and OP-1 exert direct and opposite effects on renal branching morphogenesis

1997 • 138 citations

Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1

2001 • 137 citations

Laminin and β1 Integrins Are Crucial for Normal Mammary Gland Development in the Mouse

1999 • 136 citations

Regulation of mitogenesis, motogenesis, and tubulogenesis by hepatocyte growth factor in renal collecting duct cells

1994 • 127 citations

Update of extracellular matrix, its receptors, and cell adhesion molecules in mammalian nephrogenesis

2004 • 124 citations

Mammary epithelial-specific expression of the integrin linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice

2001 • 122 citations

Genes and Proteins in Renal Development

2002 • 118 citations

Loss of mdck cell α2β1 integrin expression results in reduced cyst formation, failure of hepatocyte growth factor/scatter factor-induced branching morphogenesis, and increased apoptosis

1995 • 118 citations

Integrin-linked kinase and PINCH: partners in regulation of cell-extracellular matrix interaction and signal transduction

1999 • 115 citations

Overexpression of the integrin-linked kinase mesenchymally transforms mammary epithelial cells

2001 • 108 citations

Role of Integrin-Linked Kinase in Nerve Growth Factor-Stimulated Neurite Outgrowth

2003 • 100 citations

Distribution of beta 1 and beta 3 integrins in human fetal and adult kidney.

1990 • 99 citations

BMP7 controls collecting tubule cell proliferation and apoptosis via Smad1-dependent and -independent pathways

2001 • 95 citations

Role of BMP family members during kidney development.

1999 • 87 citations

The molecular control of renal branching morphogenesis: current knowledge and emerging insights

2002 • 85 citations

ILKAP regulates ILK signaling and inhibits anchorage-independent growth

2004 • 84 citations

Involvement of Laminin Binding Integrins and Laminin-5 in Branching Morphogenesis of the Ureteric Bud during Kidney Development

2001 • 84 citations

Integrin-linked Kinase Regulates Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression in an NF-κB-dependent Manner

2002 • 75 citations

Elevated SMAD1/β-catenin molecular complexes and renal medullary cystic dysplasia in ALK3 transgenic mice

2003 • 69 citations

Integrin-linked kinase, a promising cancer therapeutic target: biochemical and biological properties

2002 • 62 citations

p38MAPK Acts in the BMP7-dependent Stimulatory Pathway during Epithelial Cell Morphogenesis and Is Regulated by Smad1

2004 • 61 citations

Integrin-linked Kinase Controls Neurite Outgrowth in N1E-115 Neuroblastoma Cells

2001 • 57 citations

Integrin-linked kinase regulates vascular morphogenesis induced by vascular endothelial growth factor

2003 • 57 citations

ERK and p38 MAP kinase are required for rat renal development

2002 • 55 citations

Role of Integrin-linked Kinase in Leukocyte Recruitment

2002 • 49 citations

Identification of PINCH in Schwann cells and DRG neurons: Shuttling and signaling after nerve injury

2003 • 43 citations

BMP-2/ALK3 and HGF signal in parallel to regulate renal collecting duct morphogenesis

2000 • 41 citations

BMPs and BMP receptors in mouse metanephric development: in vivo and in vitro studies.

2002 • 36 citations

Integrin-linked kinase is a positive mediator of L6 myoblast differentiation

2003 • 25 citations

Laminin and β1 Integrin Distribution in the Early Stages of Human Kidney Development

1999 • 21 citations