Na+ currents that fail to inactivate

A quantitative description of membrane current and its application to conduction and excitation in nerve

1952 • 21,965 citations

The Intrinsic Electrophysiological Properties of Mammalian Neurons: Insights into Central Nervous System Function

1988 • 2,304 citations

Effect of anoxia on ion distribution in the brain

1985 • 1,341 citations

Ionic basis for the electro‐responsiveness and oscillatory properties of guinea‐pig thalamic neurones in vitro.

1984 • 1,084 citations

Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices.

1980 • 1,043 citations

Intrinsic Oscillations of Neocortex Generated by Layer 5 Pyramidal Neurons

1991 • 694 citations

Subthreshold Na+-dependent theta-like rhythmicity in stellate cells of entorhinal cortex layer II

1989 • 571 citations

Differential subcellular localization of the RI and RII Na+ channel subtypes in central neurons

1989 • 467 citations

Properties of persistent sodium conductance and calcium conductance of layer V neurons from cat sensorimotor cortex in vitro

1985 • 430 citations

A voltage-dependent persistent sodium current in mammalian hippocampal neurons.

1990 • 377 citations

Infarct Rim: Effect of Hyperglycemia on Direct Current Potential and [¹⁴C]2-Deoxyglucose Phosphorylation

1986 • 334 citations

Functional Modulation of Brain Sodium Channels by Protein Kinase C Phosphorylation

1991 • 325 citations

Coagulation factors and the increased risk of stroke in nonvalvular atrial fibrillation.

1990 • 310 citations

Modal gating of Na+ channels as a mechanism of persistent Na+ current in pyramidal neurons from rat and cat sensorimotor cortex

1993 • 303 citations

The Effect of MK-801 on Cortical Spreading Depression in the Penumbral Zone following Focal Ischaemia in the Rat

1992 • 290 citations

Common modes of drug action on Na+ channels: local anesthetics, antiarrhythmics and anticonvulsants

1987 • 287 citations

Ion channel expression by white matter glia: The type-1 astrocyte

1990 • 262 citations

Negative slope conductance due to a persistent subthreshold sodium current in cat neocortical neurons in vitro

1982 • 259 citations

Anomalous inward rectification in hippocampal neurons

1979 • 248 citations

Inward sodium current at resting potentials in single cardiac myocytes induced by the ischemic metabolite lysophosphatidylcholine.

1992 • 247 citations

Frequency and voltage-dependent inhibition of type IIA Na+ channels, expressed in a mammalian cell line, by local anesthetic, antiarrhythmic, and anticonvulsant drugs.

1991 • 222 citations

Electrophysiological characteristics of neurones in the guinea‐pig deep cerebellar nuclei in vitro.

1986 • 181 citations

Voltage dependence of excitatory postsynaptic potentials of rat neocortical neurons

1991 • 169 citations

Fast and slow gating of sodium channels encoded by a single mRNA

1990 • 162 citations

Gating of Na channels. Inactivation modifiers discriminate among models.

1987 • 150 citations

The regional vulnerability to hypoglycemia-induced neurotoxicity in organotypic hippocampal culture: protection by early tetrodotoxin or delayed MK-801

1992 • 140 citations

Dependence of hypoxic cellular calcium loading on Na(+)-Ca2+ exchange.

1992 • 131 citations

Tertiary and quaternary local anesthetics protect CNS white matter from anoxic injury at concentrations that do not block excitability

1992 • 121 citations

Threshold channels—a novel type of sodium channel in squid giant axon

1984 • 113 citations

Reduction of glutamate release and protection against ischemic brain damage by BW 1003C87

1992 • 107 citations

The effect of blocking sodium influx on anoxic damage in the rat hippocampal slice

1989 • 94 citations

A novel tetrodotoxin-insensitive, slow sodium current in striatal and hippocampal beurons

1993 • 88 citations

Conditions for pharmacologic evaluation in the gerbil model of forebrain ischemia.

1989 • 87 citations

The barbiturate thiopental reduces ATP levels during anoxia but improves electrophysiological recovery and ionic homeostasis in the rat hippocampal slice

1992 • 66 citations

Cerebral cation shifts in hypoxic-ischemic brain damage are prevented by the sodium channel blocker tetrodotoxin

1988 • 65 citations

Effects of lignocaine and quinidine on the persistent sodium current in rat ventricular myocytes

1992 • 63 citations

The possible involvement of tetrodotoxin-sensitive ion channels in ischemic neuronal damage in the rat hippocampus

1991 • 63 citations

Depolarizing prepotentials are Na+ dependent in CA1 pyramidal neurons

1985 • 56 citations

Modification of slow inactivation of single sodium channels by phenytoin in neuroblastoma cells.

1988 • 56 citations

Lidocaine accelerates neuroelectrical recovery after incomplete global ischemia in rabbits.

1990 • 53 citations

Multiple kinetic components of sodium channel inactivation in rabbit Schwann cells.

1992 • 40 citations

Drugs acting on calcium channels: potential treatment for ischaemic stroke.

1992 • 37 citations

Preferential block of the veratridine-induced, non-inactivating Na+ current by R56865 in single cardiac Purkinje cells

1991 • 37 citations

Membrane conductances involved in amplification of small signals by sodium channels in photoreceptors of drone honey bee.

1992 • 34 citations

Ca-sensitive slow inactivation and lidocaine-induced block of sodium channels in rat cardiac cells

1991 • 18 citations

Glutamate-induced action potentials are preceded by regenerative prepotentials in rat hippocampal pyramidal cells in vitro

1992 • 10 citations