Multiple Sclerosis and Glutamate

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain

1999 • 2,023 citations

Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis

1993 • 1,908 citations

Copolymer 1 reduces relapse rate and improves disability in relapsing‐remitting multiple sclerosis

1995 • 1,903 citations

Glutamate-mediated astrocyte–neuron signalling

1994 • 1,688 citations

Axonal damage in acute multiple sclerosis lesions

1997 • 1,543 citations

Glia: listening and talking to the synapse

2001 • 1,401 citations

From charcot to lou gehrig: deciphering selective motor neuron death in als

2001 • 1,373 citations

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a Neuroprotectant for Cerebral Ischemia

1990 • 1,125 citations

CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity

2001 • 1,024 citations

Placebo-controlled multicentre randomised trial of interferon β-1b in treatment of secondary progressive multiple sclerosis

1998 • 931 citations

Interferon beta‐lb in the treatment of multiple sclerosis

1995 • 899 citations

Acute axonal injury in multiple sclerosis: Correlation with demyelination and inflammation

2000 • 889 citations

A randomized trial of plasma exchange in acute central nervous system inflammatory demyelinating disease

1999 • 878 citations

Glutamate excitotoxicity in a model of multiple sclerosis

2000 • 832 citations

N-Acetyl-L-Aspartic acid: A literature review of a compound prominent in 1H-NMR spectroscopic studies of brain

1989 • 775 citations

Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein.

1988 • 721 citations

Autoantibodies to Glutamate Receptor GluR3 in Rasmussen's Encephalitis

1994 • 675 citations

OBSERVATIONS ON ATTEMPTS TO PRODUCE ACUTE DISSEMINATED ENCEPHALOMYELITIS IN MONKEYS

1933 • 629 citations

Neurological disability correlates with spinal cord axonal loss and reducedN-acetyl aspartate in chronic multiple sclerosis patients

2000 • 559 citations

Multiple sclerosis: Remyelination of nascent lesions: Remyelination of nascent lesions

1993 • 556 citations

Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists

1991 • 554 citations

Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity

1998 • 538 citations

Regulation of Class I MHC Gene Expression in the Developing and Mature CNS by Neural Activity

1998 • 538 citations

Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions

1994 • 534 citations

Recent stereological methods for cell biology: a brief survey

1990 • 504 citations

Imaging axonal damage of normal-appearing white matter in multiple sclerosis

1998 • 483 citations

Axonal pathology in multiple sclerosis: relationship to neurologic disability

1999 • 481 citations

Autoimmune encephalomyelitis ameliorated by AMPA antagonists

2000 • 467 citations

Multiple sclerosis: Altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage

2001 • 461 citations

Induction of MHC Class I Genes in Neurons

1995 • 446 citations

Murine brain macrophages induce NMDA receptor mediated neurotoxicity in vitro by secreting glutamate

1991 • 421 citations

Patterns of oligodendroglia pathology in multiple sclerosis

1994 • 403 citations

Randomised placebo-controlled trial of monthly intravenous immunoglobulin therapy in relapsing-remitting multiple sclerosis

1997 • 386 citations

Quantitative pathological evidence for axonal loss in normal appearing white matter in multiple sclerosis

2000 • 367 citations

Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes

1997 • 352 citations

Molecular dissection of the myelinated axon

1993 • 352 citations

Interferon beta in the treatment of multiple sclerosis

1998 • 340 citations

Spontaneous recovery of rats from experimental allergic encephalomyelitis is dependent on regulation of the immune system by endogenous adrenal corticosteroids.

1989 • 339 citations

Glial cells of the oligodendrocyte lineage express both kainate- and AMPA-preferring subtypes of glutamate receptor

1994 • 318 citations

Biological Interaction Between Lymphocytes and. Other Cells

1956 • 317 citations

Tumor Necrosis Factor α Inhibits Glutamate Uptake by Primary Human Astrocytes

1996 • 317 citations

AMPA–Kainate Subtypes of Glutamate Receptor in Rat Cerebral Microglia

2000 • 304 citations

Glutamate, excitotoxicity and amyotrophic lateral sclerosis

1997 • 294 citations

Mechanisms of Ionotropic Glutamate Receptor-Mediated Excitotoxicity in Isolated Spinal Cord White Matter

2000 • 292 citations

Kir4.1 Potassium Channel Subunit Is Crucial for Oligodendrocyte Development andIn VivoMyelination

2001 • 291 citations

Animal models for autoimmune demyelinating disorders of the nervous system

2000 • 287 citations

Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury

1999 • 281 citations

Parvalbumin and calbindin D‐28k in the human motor system and in motor neuron disease

1993 • 279 citations

Randomized placebo-controlled trial of mitoxantrone in relapsing-remitting multiple sclerosis: 24-month clinical and MRI outcome

1997 • 274 citations

AMPA/Kainate Receptor Activation Mediates Hypoxic Oligodendrocyte Death and Axonal Injury in Cerebral White Matter

2001 • 259 citations

Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement

1989 • 243 citations

In Vitro Expression of N‐Acetyl Aspartate by Oligodendrocytes

2000 • 233 citations

Apoptosis in the nervous system in experimental allergic encephalomyelitis

1991 • 229 citations

Comparing Deficits Following Excitotoxic and Contusion Injuries in the Thoracic and Lumbar Spinal Cord of the Adult Rat

1999 • 220 citations

Oligodendrocytes in the early course of multiple sclerosis

1994 • 215 citations

Calcium‐permeable α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid receptors: A molecular determinant of selective vulnerability in amyotrophic lateral sclerosis

1997 • 210 citations

The role of the neuroendocrine system in determining genetic susceptibility to experimental allergic encephalomyelitis in the rat.

1990 • 201 citations

Hypothesis: A role for tumor necrosis factor in immune-mediated demyelination and its relevance to multiple sclerosis

1988 • 199 citations

Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis

1998 • 198 citations

Induction of chronic relapsing experimental allergic encephalomyelitis in Biozzi mice

1990 • 194 citations

Tumor Necrosis Factor-α Induces cFOS and Strongly Potentiates Glutamate-Mediated Cell Death in the Rat Spinal Cord

2001 • 187 citations

Selective Blocking of Voltage-Gated K+ Channels Improves Experimental Autoimmune Encephalomyelitis and Inhibits T Cell Activation

2001 • 187 citations

Astrocyte-induced modulation of synaptic transmission

1999 • 183 citations

Distribution of a calcium channel subunit in dystrophic axons in multiple sclerosis and experimental autoimmune encephalomyelitis

2001 • 183 citations

Glutamate receptor subunit 2-selective antibody shows a differential distribution of calcium-impermeable AMPA receptors among populations of neurons

1997 • 183 citations

Paraneoplastic Neurologic Syndromes: Pathogenesis and Physiopathology

1999 • 179 citations

Chromatin changes in apoptosis

1981 • 177 citations

Relating axonal injury to functional recovery in MS

2000 • 171 citations

Neurotransmitters in cerebrospinal fluid reflect pathological activity

1997 • 168 citations

ZK200775: A phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauma

1998 • 162 citations

Pathology, histochemistry and immunocytochemistry of lesions in acute multiple sclerosis

1989 • 160 citations

Amino acid sequence of the smaller basic protein from rat brain myelin

1974 • 159 citations

Increased severity of experimental autoimmune encephalomyelitis, chronic macrophage/microglial reactivity, and demyelination in transgenic mice producing tumor necrosis factor‐α in the central nervous system

1997 • 142 citations

Light and electron microscopic immunocytochemical localization of AMPA‐selective glutamate receptors in the rat spinal cord

1994 • 141 citations

Pathophysiology of oligodendroglial excitotoxicity

1996 • 137 citations

α‐Amino‐3‐Hydroxy‐5‐Methyl‐4‐Isoxazolepropionate (AMPA) Receptors Mediate Excitotoxicity in the Oligodendroglial Lineage

1995 • 136 citations

A longitudinal study of T1 hypointense lesions in relapsing MS

2000 • 134 citations

Drug therapy for acquired pendular nystagmus in multiple sclerosis

1996 • 131 citations

Tumour necrosis factor alpha mRNA expression in early multiple sclerosis lesions: Correlation with demyelinating activity and oligodendrocyte pathology

2000 • 131 citations

TNF-α mediates SDF-1α–induced NF-κB activation and cytotoxic effects in primary astrocytes

2001 • 128 citations

Characteristics of acute and chronic kainate excitotoxic damage to the optic nerve

1998 • 124 citations

Disease-modifying drugs for multiple sclerosis: a rapid and systematic review.

2000 • 120 citations

Phosphorylation of selected serine and threonine residues in myelin basic protein by endogenous and exogenous protein kinases

1974 • 115 citations

Motor Neuron Degeneration Induced by Excitotoxin Agonists Has Features in Common with those Seen in the SOD-1 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

1996 • 114 citations

Memantine abrogates neurological deficits, but not CNS inflammation, in Lewis rat experimental autoimmune encephalomyelitis

1996 • 112 citations

Cerebrospinal fluid hypoxanthine, xanthine and uric acid levels may reflect glutamate-mediated excitotoxicity in different neurological diseases

1997 • 110 citations

Cellular pathology of the central nervous system.

2002 • 105 citations

Glutamate metabolism is down-regulated in astrocytes during experimental allergic encephalomyelitis

1997 • 102 citations

Axonal Injury or Loss in the Internal Capsule and Motor Impairment in Multiple Sclerosis

2000 • 98 citations

Kainic acid induces early and delayed degenerative neuronal changes in rat spinal cord

1989 • 94 citations

The Neuropathology of Paraneoplastic Syndromes

1999 • 93 citations

Axonal L-Type Ca²⁺ Channels and Anoxic Injury in Rat CNS White Matter

2001 • 92 citations

Capillary NMDA receptors regulate blood-brain barrier function and breakdown

1992 • 88 citations

The active role of astrocytes in synaptic transmission

1999 • 86 citations

The role of excitotoxicity in ALS - what is the evidence?

2000 • 85 citations

The nature of inflammatory components during demyelination in multiple sclerosis

1988 • 85 citations

Experimental Autoimmune Encephalomyelitis

2004 • 84 citations

The determinants of screening uptake and interventions for increasing uptake

2000 • 78 citations

Expression of MHC class I heavy chain and β2-microglobulin in rat brainstem motoneurons and nigral dopaminergic neurons

1999 • 75 citations

MK-801 limits neurovascular dysfunction during experimental allergic encephalomyelitis.

1997 • 70 citations

Neurotoxin Quinolinic Acid Is Selectively Elevated in Spinal Cords of Rats with Experimental Allergic Encephalomyelitis

1995 • 69 citations

Does the extent of axonal loss and demyelination from chronic lesions in multiple sclerosis correlate with the clinical subgroup?

1999 • 61 citations

Demyelination and neurological signs in experimental allergic encephalomyelitis

1987 • 58 citations

Excitotoxicity in the embryonic chick spinal cord

1991 • 57 citations

Experimental Allergic Encephalomyelitis and the 'Auto-Allergic' Diseases

1958 • 55 citations

The pathophysiology of myelin basic protein-induced acute experimental allergic encephalomyelitis in the Lewis rat

1988 • 52 citations

Concomitant detection of changes in myelin basic protein and permeability of blood-spinal cord barrier in acute experimental autoimmune encephalomyelitis by electroimmunoblotting

1985 • 52 citations

Apoptosis of T cells and Macrophages in the Central Nervous System of Intact and Adrenalectomized Lewis Rats During Experimental Allergic Encephalomyelitis

1996 • 50 citations

Control of myelination, axonal growth, and synapse formation in spinal cord explants by ion channels and electrical activity

1995 • 50 citations

The effects of N-acetylated alpha-linked acidic dipeptidase (NAALADase) inhibitors on [3H]NAAG catabolism in vivo

1989 • 49 citations

Experimental autoimmune encephalomyelitis

1982 • 45 citations

Measures of brain and spinal cord atrophy in multiple sclerosis.

1998 • 44 citations

2,3-Benzodiazepine AMPA Antagonists

1998 • 43 citations

Effectiveness of Amantadine in Reducing Relapses in Multiple Sclerosis

1987 • 40 citations

Experimental Allergic Encephalomyelitis and the "Auto-Allergic" Diseases

1960 • 40 citations

Regulation of Chronic Relapsing Experimental Allergic Encephalomyelitis by Endogenous and Exogenous Glucocorticoids

1997 • 36 citations

Autoantibodies to neuronal glutamate receptors in patients with paraneoplastic neurodegenerative syndrome enhance receptor activation.

1995 • 35 citations

Autoantibodies to Neuronal Glutamate Receptors in Patients with Paraneoplastic Neurodegenerative Syndrome Enhance Receptor Activation

1995 • 33 citations

Induction of experimental autoimmune encephalomyelitis by CD4+ T cells specific for an astrocyte protein, Sl00ß

1997 • 33 citations

Oligoclonal Banding in MS^a

1984 • 31 citations

The effect of oral and intravenous methylprednisolone treatment on subsequent relapse rate in multiple sclerosis

2000 • 30 citations

Acute and late neurotoxicity in the rat spinal cord in vivo induced by glutamate receptor agonists

1995 • 29 citations

Effect of central administration of the non-NMDA receptor antagonist DNQX on ACTH and corticosterone release before and during immobilization stress.

1997 • 29 citations

Myelin/Axonal Pathology in Interleukin-12 Induced Serial Relapses of Experimental Allergic Encephalomyelitis in the Lewis Rat

2001 • 29 citations

Amino acid concentrations in cerebrospinal fluid of patients with multiple sclerosis

1997 • 17 citations

Reactive gliosis in the brains of Lewis rats with experimental allergic encephalomyelitis

1990 • 14 citations

Glycine in the Central Nervous System in Experimental Allergic Encephalomyelitis

1980 • 13 citations

Changes in Amino Acid Contents in the Spinal Cord and Brainstem of Rats with Experimental Autoimmune Encephalomyelitis

1989 • 11 citations

Does glutamate mediate brain damage in acute encephalitis?

1998 • 9 citations

Calcium antagonists suppress experimental allergic neuritis (EAN)

1992 • 7 citations

Invasion of neurones in vitro by non-immune lymphocytes.

1967 • 4 citations

Excitotoxicity, Genetics and Neurodegeneration in Amyotrophic Lateral Sclerosis

1998 • 1 citations