Excitotoxicity in glial cells

Mitochondria and Apoptosis

1998 • 8,909 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Cloned Glutamate Receptors

1994 • 3,989 citations

Glutamate uptake

2001 • 3,867 citations

Glutamate receptor ion channels

2005 • 3,667 citations

Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders

1994 • 2,668 citations

Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate

1996 • 2,470 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

Greenfield's Neuropathology

1964 • 1,429 citations

Glutamate neurotoxicity in cortical cell culture

1987 • 1,400 citations

Calcium-binding proteins in the nervous system

1992 • 1,321 citations

Pathways to neuronal injury and apoptosis in HIV-associated dementia

2001 • 1,190 citations

The changing landscape of ischaemic brain injury mechanisms

1999 • 1,111 citations

Glutamate release in severe brain ischaemia is mainly by reversed uptake

2000 • 1,105 citations

The Toxic Effect of Sodium L-Glutamate on the Inner Layers of the Retina

1957 • 1,061 citations

CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity

2001 • 1,024 citations

Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus

2000 • 967 citations

Glutamate excitotoxicity in a model of multiple sclerosis

2000 • 832 citations

Greenfield's Neuropathology

1997 • 811 citations

Glutamate-induced neuron death requires mitochondrial calcium uptake

1998 • 623 citations

Demyelination: The Role of Reactive Oxygen and Nitrogen Species

1999 • 579 citations

Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging

1998 • 575 citations

Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity

1998 • 538 citations

Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention

1993 • 512 citations

Ion channels in glial cells

2000 • 495 citations

Brain Lesions in an Infant Rhesus Monkey Treated with Monosodium Glutamate

1969 • 471 citations

Autoimmune encephalomyelitis ameliorated by AMPA antagonists

2000 • 467 citations

Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes

1994 • 462 citations

Glutamate neurotoxicity, oxidative stress and mitochondria

2001 • 354 citations

Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes

1997 • 352 citations

The link between excitotoxic oligodendroglial death and demyelinating diseases

2001 • 345 citations

Bax Involvement in p53-Mediated Neuronal Cell Death

1998 • 337 citations

Rapid Ischemic Cell Death in Immature Oligodendrocytes: A Fatal Glutamate Release Feedback Loop

2000 • 320 citations

Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo

1996 • 311 citations

Mitochondria in Neurodegeneration: Bioenergetic Function in Cell Life and Death

1999 • 294 citations

Mechanisms of Ionotropic Glutamate Receptor-Mediated Excitotoxicity in Isolated Spinal Cord White Matter

2000 • 292 citations

Anoxic and Ischemic Injury of Myelinated Axons in CNS White Matter: From Mechanistic Concepts to Therapeutics

1998 • 290 citations

Ca2+–Zn2+ permeable AMPA or kainate receptors: possible key factors in selective neurodegeneration

2000 • 246 citations

Assessment of Animal Models for MS and Demyelinating Disease in the Design of Rational Therapy

1999 • 245 citations

Oxidative Glutamate Toxicity Can Be a Component of the Excitotoxicity Cascade

2001 • 244 citations

Delayed Mitochondrial Dysfunction in Excitotoxic Neuron Death: CytochromecRelease and a Secondary Increase in Superoxide Production

2000 • 233 citations

Selective Glial Vulnerability following Transient Global Ischemia in Rat Brain

1998 • 206 citations

Rapid Ca²⁺Entry through Ca²⁺-Permeable AMPA/Kainate Channels Triggers Marked Intracellular Ca²⁺Rises and Consequent Oxygen Radical Production

1998 • 203 citations

Shaping excitation at glutamatergic synapses

1999 • 202 citations

Fast Removal of Synaptic Glutamate by Postsynaptic Transporters

2000 • 173 citations

Neurotransmitters in cerebrospinal fluid reflect pathological activity

1997 • 168 citations

NEURONAL INJURY ASSOCIATED WITH HIV-1: Approaches to Treatment

1998 • 168 citations

Gliotoxic Action of Glutamate on Cultured Astrocytes

2000 • 166 citations

AMPA and Kainate Receptors Each Mediate Excitotoxicity in Oligodendroglial Cultures

1999 • 150 citations

Expression of Ionotropic Glutamate Receptor Subunits in Glial Cells of the Hippocampal CA1 Area following Transient Forebrain Ischemia

1997 • 146 citations

Glutamate release from microglia via glutamate transporter is enhanced by amyloid-beta peptide

1999 • 144 citations

Apoptotic Pathways Mobilized in Microglia and Neurones as a Consequence of Chromogranin A‐Induced Microglial Activation

1999 • 142 citations

Pathophysiology of oligodendroglial excitotoxicity

1996 • 137 citations

Characteristics of acute and chronic kainate excitotoxic damage to the optic nerve

1998 • 124 citations

Expression of glutamate transporters in rat optic nerve oligodendrocytes

1999 • 119 citations

Ischemic damage and subsequent proliferation of oligodendrocytes in focal cerebral ischemia

1997 • 116 citations

Ca2+ Influx through AMPA or Kainate Receptors Alone Is Sufficient to Initiate Excitotoxicity in Cultured Oligodendrocytes

2002 • 115 citations

AMPA receptor activation is rapidly toxic to cortical astrocytes when desensitization is blocked

1996 • 108 citations

Ionotropic Glutamate Receptors in the CNS

1999 • 105 citations

Calcium permeability of glutamate-gated channels in the central nervous system

1996 • 98 citations

Mitochondria Control AMPA/Kainate Receptor-Induced Cytoplasmic Calcium Deregulation in Rat Cerebellar Granule Cells

2001 • 60 citations

Chapter 9 Pharmacology of AMPA Antagonists and their Role in Neuroprotection

1996 • 57 citations

Altered Expression of the Glutamate Transporter EAAC1 in Neurons and Immature Oligodendrocytes after Transient Forebrain Ischemia

2000 • 54 citations

Australians seek international allies in battle over uranium mine

1999 • 41 citations

On How Altered Glutamate Homeostasis May Contribute to Demyelinating Diseases of the Cns

1999 • 23 citations

Ischemic damage and subsequent proliferation of oligodendrocytes in focal cerebral ischemia

1997 • 18 citations

Differential Sensitivity of Cultured Tanycytes and Astrocytes to Hydrogen Peroxide Toxicity

1999 • 13 citations

Kainate Receptors

1999 • 7 citations