Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of IκB kinase and NFκB activation in macrophages

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1991 • 15,563 citations

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1994 • 4,698 citations

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1994 • 2,945 citations

Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.

1994 • 2,216 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

Stability of curcumin in buffer solutions and characterization of its degradation products

1997 • 1,598 citations

Activation of Transcription Factor NF-κB Is Suppressed by Curcumin (Diferuloylmethane)

1995 • 1,352 citations

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

1998 • 1,070 citations

Anti-tumour and antioxidant activity of natural curcuminoids

1995 • 1,068 citations

Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis

1994 • 1,065 citations

Biotransformation of curcumin through reduction and glucuronidation in mice.

1999 • 897 citations

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

1992 • 877 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate.

1988 • 735 citations

Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity.

1999 • 719 citations

Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway

1997 • 712 citations

Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.

1995 • 682 citations

Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.

1987 • 678 citations

Nitric oxide synthase activity in human breast cancer

1995 • 637 citations

Curcumin Blocks Cytokine-Mediated NF-κB Activation and Proinflammatory Gene Expression by Inhibiting Inhibitory Factor I-κB Kinase Activity

1999 • 616 citations

Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice.

1994 • 550 citations

(-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB.

1997 • 547 citations

NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176

1998 • 533 citations

Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

1998 • 531 citations

Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures.

1992 • 484 citations

Curcumin, an Anti-tumor Promoter and Anti-inflammatory Agent, Inhibits Induction of Nitric Oxide Synthase in Activated Macrophages

1995 • 477 citations

(−)-Epigallocatechin-3-gallate Blocks the Induction of Nitric Oxide Synthase by Down-Regulating Lipopolysaccharide-Induced Activity of Transcription Factor Nuclear Factor-κB

1997 • 452 citations

Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis

1996 • 428 citations

Nitric oxide synthase activity in human gynecological cancer.

1994 • 428 citations

Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin

1998 • 399 citations

In Vivo Inhibition of Nitric Oxide Synthase Gene Expression by Curcumin, a Cancer Preventive Natural Product with Anti-Inflammatory Properties

1998 • 395 citations

Potential genotoxicity of chronically elevated nitric oxide: A review

1995 • 385 citations

Involvement of the β-diketone moiety in the antioxidative Mechanism of Tetrahydrocurcumin

1996 • 385 citations

MEKK1 activates both IκB kinase α and IκB kinase β

1998 • 382 citations

Expression of nitric oxide synthase in human central nervous system tumors.

1995 • 370 citations

Nitric Oxide: A Neural Messenger

1995 • 346 citations

Cloning of Inducible Nitric Oxide Synthase in Rat Vascular Smooth Muscle Cells

1993 • 319 citations

Antioxidative Activity of Tetrahydrocurcuminoids

1995 • 295 citations

Heat Shock Protein 70 Suppresses Astroglial-inducible Nitric-oxide Synthase Expression by Decreasing NFκB Activation

1996 • 294 citations

Curcumin inhibits cyclooxygenase-2 transcription in bile acid- and phorbol ester-treated human gastrointestinal epithelial cells

1999 • 288 citations

Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation

1998 • 282 citations

Inhibitory effects of curcumin on tumor initiation by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene

1992 • 266 citations

Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B.

1996 • 265 citations

Metabolism of curcumn-studies with [3H]curcumin

1981 • 245 citations

Suppression of lipopolysaccharide-induced nuclear factor-κB activity by theaflavin-3,3′-digallate from black tea and other polyphenols through down-regulation of IκB kinase activity in macrophages

2000 • 227 citations

Nitric oxide synthases

1996 • 222 citations

Effects of curcumin, demethoxycurcumin, bisdemethoxycurcumin and tetrahydrocurcumin on 12-O-tetradecanoylphorbol-13-acetateinduced tumor promotion

1995 • 194 citations

Chloromethyl ketones block induction of nitric oxide synthase in murine macrophages by preventing activation of nuclear factor-kappa B.

1995 • 167 citations

Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production

1995 • 153 citations

Antimutagenic and anticarcinogenic activity of natural and synthetic curcuminoids

1996 • 136 citations

Tumor necrosis factor-alpha induces expression of monocyte chemoattractant JE via fos and jun genes in clonal osteoblastic MC3T3-E1 cells

1993 • 116 citations

Stimulation of inducible nitric oxide synthase in rat liver by hyaluronan fragments

1998 • 99 citations

Diarylheptanoids from the rhizomes of Curcuma xanthorrhiza and Alpinia officinarum.

1987 • 98 citations

Negative regulation of macrophage activation in response to IFN-gamma and lipopolysaccharide by the STK/RON receptor tyrosine kinase.

1999 • 89 citations

Negative Regulation of Macrophage Activation in Response to IFN-γ and Lipopolysaccharide by the STK/RON Receptor Tyrosine Kinase

1999 • 78 citations

Functional Coupling of Endogenous Serotonin (5‐HT_1B) and Calcitonin (C1a) Receptors in CHO Cells to a Cyclic AMP‐Responsive Luciferase Reporter Gene

1997 • 61 citations

Effects of lactobacillus, antacids and antibiotics on the levels of nitrite in the gastro-intestinal tracts of rats fed sodium nitrate

1982 • 20 citations