Curcumin in Management of Chronic Obstructive Pulmonary Disease

NCT04687449

NAINTERVENTIONAL

Danbury Hospital

120 participants

Started 2022-01-01 · Completed 2023-12-15

Status: Unknown (as of 12-23-2025)

Conditions

COPD

Interventions

DIETARY_SUPPLEMENT: Curcumin therapy OTHER: Placebo OTHER: Standard care

Linked Papers (from SciSciNet-V2)

Total Papers15

Background

4

Result

0

Derived

0

Unknown

11

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

In this double-blind, placebo-controlled trial, 120 patients with a diagnosis of COPD will be randomized to receive either a daily curcumin preparation or placebo for 90 days, in addition to the standard of care treatment. The outcomes will be compared between the study arms. No dose escalation will be used.

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Background Papers8

Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Understanding the impact of symptoms on the burden of COPD

Understanding the impact of symptoms on the burden of COPD

Understanding Why Patients With COPD Get Readmitted

Understanding Why Patients With COPD Get Readmitted

Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments

Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers11

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: the GOLD science committee report 2019

1,617 citations

A Qualitative Systematic Overview of the Measurement Properties of Functional Walk Tests Used in the Cardiorespiratory Domain

1,043 citations

Chronic obstructive pulmonary disease

Interpreting thresholds for a clinically significant change in health status in asthma and COPD

Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF- B activation through inhibition of I B kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1

Curcumin attenuates elastase- and cigarette smoke-induced pulmonary emphysema in mice

Curcumin Attenuates Airway Inflammation and Airway Remolding by Inhibiting NF-κB Signaling and COX-2 in Cigarette Smoke-Induced COPD Mice

Introducing the COPD Foundation Guide for Diagnosis and Management of COPD, Recommendations of the COPD Foundation

Curcumin ameliorates alveolar epithelial injury in a rat model of chronic obstructive pulmonary disease

Curcumin Alters the Pharmacokinetics of Warfarin and Clopidogrel in Wistar Rats but Has No Effect on Anticoagulation or Antiplatelet Aggregation

A randomized, double-blind, placebo- controlled study on the anti-haemostatic effects of Curcuma longa, Angelica sinensis and Panax ginseng