Cytoskeletal Activation and Altered Gene Expression in Endothelial Barrier Regulation by Simvastatin

Gene Ontology: tool for the unification of biology

2000 • 38,297 citations

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

1994 • 8,631 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

1994 • 2,615 citations

Rho GTPases and their effector proteins

2000 • 1,941 citations

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

2002 • 1,225 citations

Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase mRNA Stability by Rho GTPase

1998 • 1,034 citations

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2001 • 954 citations

MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data

2003 • 865 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 830 citations

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2000 • 461 citations

Dbl family guanine nucleotide exchange factors

2001 • 414 citations

Cortactin Localization to Sites of Actin Assembly in Lamellipodia Requires Interactions with F-Actin and the Arp2/3 Complex

2000 • 410 citations

An invasion-related complex of cortactin, paxillin and PKCμ associates with invadopodia at sites of extracellular matrix degradation

1999 • 355 citations

The Effect of Statins on Mortality in Patients with Bacteremia

2001 • 338 citations

The Role of Tyrosine Phosphorylation of Cortactin in the Locomotion of Endothelial Cells

1998 • 271 citations

Differential effect of MLC kinase in TNF-α-induced endothelial cell apoptosis and barrier dysfunction

2001 • 216 citations

3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis

2002 • 213 citations

Shear Stress-Mediated Cytoskeletal Remodeling and Cortactin Translocation in Pulmonary Endothelial Cells

2002 • 212 citations

Impact of HMG CoA reductase inhibition on small GTPases in the heart

2002 • 206 citations

Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1

1998 • 197 citations

Involvement of Rho GTPases in the Transcriptional Inhibition of Preproendothelin-1 Gene Expression by Simvastatin in Vascular Endothelial Cells

2000 • 191 citations

Regulation of endothelial cell gap formation and paracellular permeability.

1995 • 165 citations

Withdrawal of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Elicits Oxidative Stress and Induces Endothelial Dysfunction in Mice

2002 • 165 citations

Protein kinase C phosphorylates caldesmon₇₇ and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers

1992 • 163 citations

Attenuation of chronic hypoxic pulmonary hypertension by simvastatin

2003 • 162 citations

A high-density probe array sample preparation method using 10- to 100-fold fewer cells

1999 • 160 citations

Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase‐3β

2002 • 159 citations

Regulation of endothelial cell myosin light chain kinase by Rho, cortactin, and p60^src

1999 • 157 citations

Simvastatin Improves Disturbed Endothelial Barrier Function

2000 • 147 citations

Phosphocreatine content in single fibers of human muscle after sustained submaximal exercise

1997 • 139 citations

The Breast Cancer β4 Integrin and Endothelial Human CLCA2 Mediate Lung Metastasis

2001 • 132 citations

Mechanisms of ionomycin-induced endothelial cell barrier dysfunction

1997 • 98 citations

Simvastatin upregulates coronary vascular endothelial nitric oxide production in conscious dogs

2000 • 98 citations

Differential regulation of Rho GTPases by β1 and β3 integrins: the role of an extracellular domain of integrin in intracellular signaling

2002 • 97 citations

Statins decrease bone turnover in postmenopausal women: a cross‐sectional study

2002 • 79 citations

Location of focal silver staining at endothelial gaps in inflamed venules examined by scanning electron microscopy

1995 • 69 citations

Deoxygenation-induced cation fluxes in sickle cells. IV. Modulation by external calcium

1995 • 49 citations

Further evidence for direct vascular actions of statins: Effect on endothelial nitric oxide synthase and adhesion molecules

2001 • 41 citations

Deficiency of different nitric oxide synthase isoforms activates divergent transcriptional programs in cardiac hypertrophy

2003 • 38 citations

Differential effect of simvastatin on activation of Rac1 vs. activation of the heat shock protein 27-mediated pathway upon oxidative stress, in human smooth muscle cells

2002 • 34 citations

Recombinant Human Soluble Thrombomodulin Delivers Bounded Thrombin to Antithrombin III: Thrombomodulin Associates with Free Thrombin and Is Recycled to Activate Protein C

1993 • 30 citations