The Activation Sequence of Thrombospondin-1 Interacts with the Latency-associated Peptide to Regulate Activation of Latent Transforming Growth Factor-β

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

1994 • 1,460 citations

Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

1998 • 1,151 citations

Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.

1988 • 648 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

Latent transforming growth factor-β: Structural features and mechanisms of activation

1997 • 511 citations

Thrombospondin causes activation of latent transforming growth factor- beta secreted by endothelial cells by a novel mechanism [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143]

1993 • 467 citations

Regulation of Transforming Growth Factor-β Activation by Discrete Sequences of Thrombospondin 1

1995 • 413 citations

Transforming growth factor-beta: a general review.

1996 • 400 citations

A new type of transforming growth factor-beta, TGF-beta 3.

1988 • 396 citations

Thrombospondins: structure and regulation of expression

1992 • 345 citations

Physicochemical Activation of Recombinant Latent Transforming Growth Factor-beta's 1, 2, and 3

1990 • 343 citations

cDNA cloning by PCR of rat transforming growth factor β-1

1990 • 274 citations

Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in a chemically defined system.

1994 • 274 citations

Molecular events in the processing of recombinant type 1 pre-pro-transforming growth factor beta to the mature polypeptide.

1988 • 273 citations

Transforming growth factor-beta complexes with thrombospondin.

1992 • 256 citations

The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta.

1994 • 250 citations

Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells.

1993 • 241 citations

Murine Transforming Growth Factor-β2 cDNA Sequence and Expression in Adult Tissues and Embryos

1989 • 220 citations

Hydropathic anti-complementarity of amino acids based on the genetic code

1984 • 216 citations

Similarity between the corticotropin (ACTH) receptor and a peptide encoded by an RNA that is complementary to ACTH mRNA.

1985 • 198 citations

Physiology of Thrombospondin

1990 • 195 citations

Identification of a novel transforming growth factor-beta (TGF-beta 5) mRNA in Xenopus laevis.

1990 • 177 citations

Thrombospondins

1991 • 169 citations

Transforming growth factor‐β: activity and efficacy in animal models of wound healing

1995 • 159 citations

Intron-exon structure of the human transforming growth factor-β precursor gene

1987 • 159 citations

The thrombospondin family

1993 • 139 citations

[4] Thrombospondins

1994 • 137 citations

Smooth muscle cell immediate-early gene and growth factor activation follows vascular injury. A putative in vivo mechanism for autocrine growth.

1993 • 130 citations

The functions of thrombospondin and its involvement in physiology and pathophysiology

1993 • 118 citations

Thrombospondin 1 precedes and predicts the development of tubulointerstitial fibrosis in glomerular disease in the rat

1998 • 97 citations

Genes induced by serum growth factors

1991 • 97 citations

Structural characterization of the latent complex between transforming growth factor β1 and β1-latency-associated peptide

1996 • 76 citations

Genetic origins of protein shape and interaction rules

1995 • 73 citations

Complete thrombospondin mRNA sequence includes potential regulatory sites in the 3' untranslated region.

1989 • 72 citations

Identification and analysis of discrete functional domains in the pro region of pre-pro-transforming growth factor beta 1.

1991 • 69 citations

Characterization of the cellular receptor for fibronectin through a hydropathic complementarity approach.

1988 • 67 citations

Determination of the Putative Binding site for Fibronectin on Platelet Glycoprotein IIb-IIIa Complex through a Hydropathic Complementarity Approach

1989 • 41 citations

Analysis of Small Latent Transforming Growth Factor-β Complex Formation and Dissociation by Surface Plasmon Resonance

1997 • 36 citations

Characterization of the binding of transforming growth factor-beta 1, -beta 2, and -beta 3 to recombinant beta 1-latency-associated peptide.

1992 • 33 citations

Correction: a new interpretation of a chicken transforming growth factor-beta 4 complementary DNA.

1992 • 27 citations

Role of Carbohydrate Structures in the Binding of β1-Latency-Associated Peptide to Ligands

1997 • 26 citations

Identification of Interactive Determinants on Idiotypic-Anti-idiotypic Antibodies through Comparison of Their Hydropathic Profiles

1994 • 17 citations

Characterization of latent recombinant TGF‐β2 produced by chinese hamster ovary cells

1991 • 17 citations

Thrombospondin co-localises with TGFβ and IGF-I in the extracellular matrix of human osteoblast-like cells and is modulated by 17β estradiol

1995 • 17 citations

Binding of Type I IL-1β Receptor Fragment 151–162 to Interleukin-1β

1994 • 3 citations