CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4⁺T cells

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

1996 • 4,184 citations

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

1996 • 1,973 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1

1996 • 1,678 citations

The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis

1988 • 1,496 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120

1995 • 983 citations

Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

1995 • 951 citations

Programmed Death of T Cells in HIV-1 Infection

1992 • 932 citations

Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals.

1992 • 907 citations

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

1992 • 689 citations

CD4-Independent Infection by HIV-2 Is Mediated by Fusin/CXCR4

1996 • 669 citations

HIV Coreceptor Downregulation as Antiviral Principle: SDF-1α–dependent Internalization of the Chemokine Receptor CXCR4 Contributes to Inhibition of HIV Replication

1997 • 564 citations

Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression.

1996 • 499 citations

Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals.

1995 • 438 citations

Cell nucleus and DNA fragmentation are not required for apoptosis.

1994 • 436 citations

Programmed Cell Death in AIDS-Related HIV and SIV Infections

1993 • 316 citations

Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals

1993 • 242 citations

Cell death: programmed, apoptosis, necrosis, or other?

1995 • 220 citations

Membrane Expression of HIV Envelope Glycoproteins Triggers Apoptosis in CD4 Cells

1993 • 210 citations

HIV-1 Directly Kills CD4+ T Cells by a Fas-independent Mechanism

1998 • 199 citations

Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals

1993 • 197 citations

Functional expression of the CXC-chemokine receptor-4/fusin on mouse microglial cells and astrocytes.

1997 • 182 citations

High expression of APO-1 (CD95) on T lymphocytes from human immunodeficiency virus-1-infected children [letter]

1994 • 174 citations

Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1-infected children

1996 • 150 citations

Interleukin 1β-converting Enzyme Related Proteases/Caspases Are Involved in TRAIL-induced Apoptosis of Myeloma and Leukemia Cells

1997 • 142 citations

The caspase-RB connection in cell death

1998 • 138 citations

Envelope glycoproteins from biologically diverse isolates of immunodeficiency viruses have widely different affinities for CD4.

1991 • 130 citations

Detection and characterization of apoptotic peripheral blood lymphocytes in human immunodeficiency virus infection and cancer chemotherapy by a novel flow immunocytometric method

1994 • 117 citations

Structure and expression of Ick transcripts in human lymphoid cells

1988 • 104 citations

Involvement of the CD4 molecule in a post‐activation event on T cell proliferation

1987 • 102 citations

The small GTPase Cdc42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes.

1997 • 88 citations

CD4+ CD8+ thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway.

1997 • 86 citations

The inhibition of pro-apoptotic ICE-like proteases enhances HIV replication

1997 • 85 citations

AIDS: a disease of impaired Th-cell renewal?

1995 • 83 citations

CD4+ blood lymphocytes are rapidly killed in vitro by contact with autologous human immunodeficiency virus-infected cells.

1995 • 78 citations

Ligation of Major Histocompatability Complex (MHC) Class I Molecules on Human T Cells Induces Cell Death through PI-3 Kinase–induced c-Jun NH2-terminal Kinase Activity: A Novel Apoptotic Pathway Distinct from Fas-induced Apoptosis

1997 • 77 citations

Two murine homologues of the human chemokine receptor CXCR4 mediating stromal cell‐derived factor 1α activation of G_i2 are differentially expressed in vivo

1997 • 75 citations

Early detection of antibody to human immunodeficiency virus type 1 by using an antigen conjugate immunoassay correlates with the presence of immunoglobulin M antibody

1992 • 68 citations

Rapid induction of apoptosis by cell-to-cell transmission of human immunodeficiency virus type 1

1995 • 64 citations

Role of the Heterotrimeric G Proteins in Stromal-Derived Factor-1α-Induced Natural Killer Cell Chemotaxis and Calcium Mobilization

1997 • 49 citations

Deletion of T lymphocytes in human CD4 transgenic mice induced by HIV‐gp120 and gp120‐specific antibodies from AIDS patients

1994 • 47 citations

Apoptosis induced by HIV infection in H9 T cells is blocked by ICE-family protease inhibition but not by a Fas(CD95) antagonist.

1996 • 46 citations