Interleukin-2 inhibits graft-versus-host disease-promoting activity of CD4+ cells while preserving CD4- and CD8-mediated graft-versus-leukemia effects

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.

1979 • 1,301 citations

Mac‐1: a macrophage differentiation antigen identified by monoclonal antibody

1979 • 1,144 citations

Human TH1 and TH2 subsets: doubt no more

1991 • 1,103 citations

Marrow Transplantation from Related Donors Other Than HLA-Identical Siblings

1985 • 844 citations

IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement.

1980 • 835 citations

Cytokine dysregulation and acute graft-versus-host disease

1992 • 617 citations

Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease.

1987 • 609 citations

MONOCLONAL ANTIBODIES TO MOUSE MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS

1982 • 471 citations

A functional dichotomy in CD4+ T lymphocytes

1988 • 369 citations

Regulation of T‐Cell Activation; Differences among T‐Cell Subsets

1989 • 271 citations

Marrow transplantation from unrelated donors for treatment of hematologic malignancies: effect of mismatching for one HLA locus

1993 • 234 citations

Unusual T cell populations in adult murine bone marrow. Prevalence of CD3+CD4-CD8- and alpha beta TCR+NK1.1+ cells.

1990 • 196 citations

Graft failure in patients receiving T cell-depleted HLA-identical allogeneic marrow transplants.

1988 • 195 citations

Selective depletion of CD8+ T lymphocytes for prevention of graft- versus-host disease after allogeneic bone marrow transplantation

1990 • 180 citations

Myelosuppressive conditioning is required to achieve engraftment of pluripotent stem cells contained in moderate doses of syngeneic bone marrow

1994 • 163 citations

Graft-versus-leukaemia reactivity induced by alloimmunisation without augmentation of graft-versus-host reactivity

1979 • 157 citations

Contribution of CD4+ and CD8+ T cells to graft-versus-host disease and graft-versus-leukemia reactivity after transplantation of MHC-compatible bone marrow.

1991 • 154 citations

Graft-versus-leukemia following bone marrow transplantation.

1987 • 149 citations

The systemic administration of purified interleukin 2 enhances the ability of sensitized murine lymphocytes to cure a disseminated syngeneic lymphoma.

1984 • 137 citations

Specific adoptive therapy of established leukemia with syngeneic lymphocytes sequentially immunized in vivo and in vitro and nonspecifically expanded by culture with Interleukin 2.

1981 • 130 citations

Surface markers of T cells causing lethal graft-vs-host disease to class I vs class II H-2 differences.

1985 • 125 citations

Interleukin 2 prevents graft-versus-host disease while preserving the graft-versus-leukemia effect of allogeneic T cells.

1990 • 122 citations

Dissociating graft-vs-host disease from the graft-vs-leukemia effect of allogeneic T cells: the potential role of IL-2.

1992 • 118 citations

IL-2 reduces graft-versus-host disease and preserves a graft-versus-leukemia effect by selectively inhibiting CD4+ T cell activity.

1993 • 115 citations

ENDOGENOUS IFN-GAMMA DURING HUMAN BONE MARROW TRANSPLANTATION

1990 • 110 citations

In vivo administration of interleukin 2 plus T cell-depleted syngeneic marrow prevents graft-versus-host disease mortality and permits alloengraftment.

1990 • 98 citations

Eradication of murine leukemia with histoincompatible marrow grafts in mice conditioned with total lymphoid irradiation (TLI)

1981 • 97 citations

T cell depletion in bone marrow transplantation for leukemia: current results and future directions.

1988 • 90 citations

T cell depletion in bone marrow transplantation.

1988 • 85 citations

Monoclonal anti-H-2Kb antibodies detect serological differences betweenH-2K b mutants

1981 • 74 citations

Immunosuppression and lymphoid hypoplasia associated with chronic graft versus host disease is dependent upon IFN-gamma production.

1990 • 68 citations

Protection against syngeneic lymphoma by a long-lived cytotoxic T-cell clone.

1982 • 63 citations

Lethal graft-vs-host disease across major histocompatibility barriers: requirement for leucyl-leucine methyl ester sensitive cytotoxic T cells.

1987 • 61 citations

BONE MARROW TRANSPLANTATION USING UNRELATED DONORS FOR PATIENTS WITH ADVANCED LEUKEMIA OR BONE MARROW FAILURE

1990 • 54 citations

Effects of T cell depletion in radiation bone marrow chimeras. III. Characterization of allogeneic bone marrow cell populations that increase allogeneic chimerism independently of graft-vs-host disease in mixed marrow recipients.

1989 • 53 citations

The role of T-cells in preventing relapse in chronic myelogenous leukemia.

1987 • 47 citations

Bone marrow transplantation across major histocompatability barriers in mice. III. Treatment of donor grafts with monoclonal antibodies directed against Lyt determinants.

1982 • 46 citations

Retention of graft-versus-leukemia using selective depletion of CD8-positive T lymphocytes for prevention of graft-versus-host disease following bone marrow transplantation for chronic myelogenous leukemia.

1991 • 41 citations

A chronic inflammatory response. Its role in supporting the development of c-myb and c-myc related promonocytic and monocytic tumors in BALB/c mice.

1988 • 35 citations

Graft-versus-leukemia effect using mixed allogeneic bone marrow transplantation.

1989 • 33 citations

Natural suppressor cells in spleens of irradiated, bone marrow-reconstituted mice and normal bone marrow: Lack of SCA-1 expression and enrichment by depletion of MAC1-positive cells

1990 • 33 citations

THE EFFECT OF T SUBSET DEPLETION ON THE INCIDENCE OF LETHAL GRAFT-VERSUS-HOST DISEASE IN AMURINE MAJOR-HISTOCOMPATIBILITY-COMPLEX-MISMATCHED TRANSPLANTATION SYSTEM

1987 • 21 citations

REACTIVITY OF IN-VITRO-EXPANDED ALLOIMMUNE CYTOTOXIC T LYMPHOCYTES and Qa-1-SPECIFIC CYTOTOXIC T LYMPHOCYTES AGAINST AKR LEUKEMIA IN VIVO1

1985 • 20 citations

Lethal graft-vs-host disease induced by a class II MHC antigen only disparity is not mediated by cytotoxic T cells.

1988 • 19 citations

Genetic analysis of the anti-leukemic effect of mixed allogeneic bone marrow transplantation.

1989 • 17 citations

THE MECHANISM OF IL-2-MEDIATED PROTECTION AGAINST GVHD IN MICE

1992 • 16 citations

Strain Dependence of Interleukin-2-Induced Graft-Versus-Host Disease Protection

1994 • 12 citations

Adoptive Immunotherapy of Leukemia in the Rat, without Graft-vs-Host Complications

1979 • 11 citations

Effector cells of lethal graft-versus-host disease (GVHD) in nude mice.

1989 • 9 citations

Bone marrow transplantation in leukemia using family donors other than HLA-identical siblings: a preliminary report from the International Bone Marrow Transplant Registry.

1987 • 8 citations

Alloengraftment in IL-2-treated mice.

1992 • 6 citations

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