An Immunodeficiency Characterized by Defective Signal Transduction in T Lymphocytes

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein

1984 • 1,132 citations

The Metabolism of Phosphoinositide-Derived Messenger Molecules

1986 • 717 citations

T Cell Subsets and the Recognition of MHC Class

1983 • 702 citations

Ion channels activated by inositol 1,4,5-trisphosphate in plasma membrane of human T-lymphocytes

1987 • 676 citations

The Role of the T3/Antigen Receptor Complex in T-Cell Activation

1986 • 627 citations

Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride.

1982 • 618 citations

The Role of Protein Kinase C in Transmembrane Signalling

1986 • 557 citations

[31] Calcium-activated, phospholipid-dependent protein kinase (protein kinase C) from rat brain

1983 • 281 citations

Human recombinant interleukin 4 induces Fc epsilon R2/CD23 on normal human monocytes.

1988 • 280 citations

Resistance to multiple hormones in patients with pseudohypoparathyroidism

1983 • 246 citations

Characteristics of a monoclonal antibody (WT-31) that recognizes a common epitope on the human T cell receptor for antigen.

1985 • 240 citations

Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes

1987 • 232 citations

A T3-like protein complex associated with the antigen receptor on murine T cells

1986 • 213 citations

Characterization of a human lymphocyte surface sialoglycoprotein that is defective in Wiskott-Aldrich syndrome.

1984 • 203 citations

Early Signal Transduction by the Antigen Receptor Without Commitment to T Cell Activation

1988 • 169 citations

Polyclonal Immunoglobulin Secretion by Human B Lymphocytes Exposed to Epstein-Barr Virus in Vitro

1979 • 155 citations

The T11 (CD2) molecule is functionally linked to the T3/Ti T cell receptor in the majority of T cells.

1987 • 148 citations

Association of protein kinase C activation with IL 2 receptor expression.

1986 • 146 citations

Sialophorin, a surface sialoglycoprotein defective in the Wiskott-Aldrich syndrome, is involved in human T lymphocyte proliferation.

1987 • 145 citations

Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor.

1987 • 141 citations

Pseudohypoparathyroidism: inheritance of deficient receptor-cyclase coupling activity.

1981 • 97 citations

Aluminum fluoride induces phosphatidylinositol turnover, elevation of cytoplasmic free calcium, and phosphorylation of the T cell antigen receptor in murine T cells.

1987 • 86 citations

Calcium and inositolphosphates in the activation of T cell-mediated cytotoxicity.

1987 • 72 citations

Population kinetics of precursors of IL 2-producing peripheral T lymphocytes: evidence for short life expectancy, continuous renewal, and post-thymic expansion.

1987 • 53 citations

Toxic shock syndrome toxin-1 induces inositol phospholipid turnover, protein kinase C translocation, and calcium mobilization in human T cells.

1988 • 52 citations

Defective expression of T cell-associated glycoprotein in severe combined immunodeficiency.

1986 • 52 citations

Requirement for mitogen, T cell-accessory cell contact, and interleukin 1 in the induction of resting T-cell proliferation

1987 • 48 citations

One-dimensional thin-layer chromatographic separation of the lipids involved in arachidonic acid metabolism

1984 • 13 citations