Possible role of IL-2 deficiency for hypogammaglobulinaemia in patients with common variable immunodeficiency

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

An improved colorimetric assay for interleukin 2

1986 • 858 citations

Classification of patients with common variable immunodeficiency by B cell secretion of IgM and IgG in response to anti-IgM and interleukin-2

1990 • 170 citations

Accelerated breakdown of immunoglobulin G (IgG) in myotonic dystrophy: a hereditary error of immunoglobulin catabolism.

1966 • 167 citations

Quantitative measurements of T- and B-cell function in "variable" primary hypogammaglobulinaemia: evidence for a consistent B-cell defect.

1977 • 140 citations

Three distinct stages of B-cell defects in common varied immunodeficiency.

1982 • 130 citations

The role of suppressor cells in the pathogenesis of common variable hypogammaglobulinemia and the immunodeficiency associated with myeloma.

1976 • 115 citations

T cell receptor triggering induces responsiveness to interleukin 1 and interleukin 2 but does not lead to T cell proliferation.

1986 • 113 citations

Cellular abnormalities in common variable immunodeficiency.

1990 • 93 citations

T cell unresponsiveness to the mitogenic activity of OKT3 antibody results from a deficiency of monocyte Fc gamma receptors for murine IgG2a and inability to cross-link the T3-Ti complex.

1985 • 90 citations

Peripheral blood lymphocytes of patients with common variable immunodeficiency (CVI) produce reduced levels of interleukin-4, interleukin-2 and interferon-gamma, but proliferate normally upon activation by mitogens.

1989 • 74 citations

Demonstration of the involvement of interleukin 2 in the differentiation of Staphylococcus aureus Cowan I-stimulated B cells.

1984 • 58 citations

Defective low-density cells of dendritic morphology from the blood of patients with common variable hypogammaglobulinaemia: low immunoglobulin production on stimulation of normal B cells.

1985 • 52 citations

Functional 'immaturity' of isolated B cells from patients with hypogammaglobulinaemia.

1980 • 48 citations

Defective Macrophage Function in a Patient with Common Variable Immunodeficiency

1982 • 46 citations

Defective DNA synthesis by T cells in acquired 'common-variable' hypogammaglobulinaemia on stimulation with mitogens.

1989 • 45 citations

Activation and immunoregulation of antigen-specific human b lymphocyte responses: multifaceted role of the monocyte.

1982 • 45 citations

Abnormalities in CD4+ T lymphocyte subsets in patients with common variable immunodeficiency

1991 • 39 citations

B cell function in acquired “common-variable” hypogammaglobulinemia: Proliferative responses to lymphokines

1989 • 36 citations

Elevated serum interleukin-6 associated with a failur in B cell differentiation in common variable immunodeficiecy†

1990 • 32 citations

Induction of IgM production by pokeweed mitogen and interleukin-2: Different responses by human peripheral blood cells and tonsil cells

1986 • 18 citations

Analysis of B cell dysfunction in patients with common variable immunodeficiency by using recombinant interleukin 2.

1987 • 9 citations

[Terminal B-cell maturation and immunoglobulin synthesis in vitro in primary and secondary immune deficiencies].

1984 • 4 citations

[Effects of IL-2 and IL-6 on the immunoglobulin synthesis of lymphocytes from CVID patients].

1990 • 2 citations

[Isolated immunoglobulin G (IgG) deficiency in dystrophia myotonica (Curschmann-Steinert)].

1990 • 1 citations