Role of replication time in the control of tissue-specific gene expression.

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

Flow cytometric measurement of total DNA content and incorporated bromodeoxyuridine.

1983 • 978 citations

Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination

1985 • 978 citations

The Mosaic Genome of Warm-Blooded Vertebrates

1985 • 887 citations

A fixed site of DNA replication in eucaryotic cells

1980 • 669 citations

Transcriptional control in the production of liver-specific mRNAs

1981 • 593 citations

Replication Timing of Genes and Middle Repetitive Sequences

1984 • 561 citations

Assembly and propagation of repressed and derepressed chromosomal states

1985 • 518 citations

The Role of X-Chromosome Inactivation during Spermatogenesis

1972 • 508 citations

Eucaryotic DNA: Organization of the genome for replication

1978 • 476 citations

Regulation of human histone gene expression: kinetics of accumulation and changes in the rate of synthesis and in the half-lives of individual histone mRNAs during the HeLa cell cycle.

1983 • 452 citations

Adult frogs derived from the nuclei of single somatic cells

1962 • 441 citations

Transformation of white locus DNA in Drosophila: Dosage compensation, zeste interaction, and position effects

1984 • 388 citations

The effect of chromosomal position on the expression of the drosophila xanthine dehydrogenase gene

1983 • 368 citations

Multienzyme complex for metabolic channeling in mammalian DNA replication.

1980 • 349 citations

Chromosomal position and activation of retroviral genomes inserted into the germ line of mice

1981 • 344 citations

Studies on unbalanced growth in tissue culture. I. Induction and consequences of thymidine deficiency.

1960 • 340 citations

Adenosine deaminase: characterization and expression of a gene with a remarkable promoter.

1985 • 329 citations

The Structure and Function of Chromatin

1972 • 286 citations

Differential Gene Expression in the Gastrula of Xenopus laevis

1983 • 270 citations

Characterization of Giemsa dark- and light-band DNA

1982 • 251 citations

Correct developmental expression of a cloned alcohol dehydrogenase gene transduced into the drosophila germ line

1983 • 248 citations

A foreign β-globin gene in transgenic mice: Integration at abnormal chromosomal positions and expression in inappropriate tissues

1983 • 245 citations

Changes in calmodulin and its mrna accompany reentry of quiescent (G0) cells into the cell cycle

1984 • 229 citations

Selective Silencing of Eukaryotic DNA

1975 • 224 citations

The cloned dopa decarboxylase gene is developmentally regulated when reintegrated into the drosophila genome

1983 • 202 citations

Mid-prophase human chromosomes. The attainment of 2000 bands

1981 • 198 citations

Assembly of transcriptionally active 5S RNA gene chromatin in vitro

1982 • 195 citations

Gene amplification in a single cell cycle in Chinese hamster ovary cells.

1984 • 190 citations

Analysis of the complexity and diversity of mRNA from chicken liver and oviduct

1976 • 184 citations

Microinjection of cloned retroviral genomes into mouse zygotes: integration and expression in the animal

1981 • 179 citations

Expression of the immunoglobulin C mu gene in mouse T and B lymphoid and myeloid cell lines.

1980 • 170 citations

Genetic Expression in the Developing Brain

1983 • 167 citations

Sequence of DNA replication in 277 R- and Q-bands of human chromosomes using a BrdU treatment

1976 • 165 citations

The distribution of interspersed repeats is nonuniform and conserved in the mouse and human genomes.

1983 • 151 citations

Transcriptional Regulation of Globin Gene Expression in the Human Erythroid Cell Line K562

1983 • 149 citations

Changes in gene position are accompanied by a change in time of replication

1984 • 147 citations

Sequence complexity of nuclear RNAs in adult rat tissues

1978 • 146 citations

Chromosomal and nuclear distribution of the HindIII 1.9-kb human DNA repeat segment

1984 • 143 citations

Complexity of cytoplasmic polyadenylated and nonpolyadenylated rat brain ribonucleic acids

1979 • 137 citations

Patterns of DNA replication of human chromosomes. II. Replication map and replication model.

1982 • 132 citations

The Creeping Vole (<i>Microtus oregoni</i>) as a Gonosomic Mosaic. I. The OY/XY Constitution of the Male

1963 • 127 citations

Expression of the chicken transferrin gene in transgenic mice

1983 • 126 citations

Analysis of deoxyribonucleic acid replication in human X chromosomes by fluorescence microscopy.

1976 • 123 citations

Irreversible Gene Repression Model for Control of Development

1978 • 117 citations

Initiation points for DNA replication in nontransformed and simian virus 40-transformed Chinese hamster lung cells

1977 • 112 citations

DNA replication patterns of human chromosomes from fibroblasts and amniotic fluid cells revealed by a Giemsa staining technique

1975 • 110 citations

Use of a cloned library for the study of abundant poly(A)+RNA during Xenopus laevis development

1980 • 107 citations

Chromosomal position effects determine transcriptional potential of integrated mammary tumor virus DNA

1982 • 101 citations

On the cloning of eukaryotic total poly(A)-RNA populations in Escherichia coli.

1980 • 98 citations

Sex determination in the European eel (<i>Anguilla anguilla, </i>L.)

1983 • 94 citations

The temporal order of replication of murine immunoglobulin heavy chain constant region sequences corresponds to their linear order in the genome

1982 • 93 citations

Temporal order of replication of Xenopus laevis 5S ribosomal RNA genes in somatic cells.

1986 • 87 citations

Fluorescence analysis of late DNA replication in human metaphase chromosomes

1975 • 84 citations

Regulation of human insulin gene expression in transgenic mice

1986 • 82 citations

Molecular events in the reproduction of animal cells

1964 • 75 citations

The temporal structure of S phase

1975 • 75 citations

ON BIOLOGICAL FUNCTIONS MAPPING TO THE HETEROCHROMATIN OF DROSOPHILA MELANOGASTER

1985 • 74 citations

Replication of alpha and beta globin DNA sequences occurs during early S phase in murine erythroleukemia cells.

1981 • 71 citations

alpha-Globulin sequences are located in a region of early-replicating DNA in murine erythroleukemia cells.

1981 • 71 citations

Evidence for a correlation between late replication and autosomal gene inactivation in a familial translocation t(X;21)

1979 • 66 citations

Chromosome banding pattern conservatism in birds and nonhomology of chromosome banding patterns between birds, turtles, snakes and amphibians

1975 • 65 citations

RNA synthesis in relation to DNA replication in synchronized Chinese hamster cell cultures

1967 • 64 citations

Resting state in normal and simian virus 40 transformed Chinese hamster lung cells.

1976 • 64 citations

The level of expression of the rat growth hormone gene in liver tumor cells is at least eight orders of magnitude less than that in anterior pituitary cells.

1983 • 62 citations

Rates of DNA synthesis during the S-phase of HeLa cells.

1978 • 62 citations

Changes in chromosomal DNA replication patterns in developing frog embryos

1970 • 61 citations

Late replication in an X-autosome translocation in the mouse: correlation with genetic inactivation and evidence for selective effects during embryogenesis.

1979 • 61 citations

Complete reactivation of X chromosomes from human chorionic villi with a switch to early DNA replication.

1986 • 58 citations

INTERMITTENT DNA SYNTHESIS AND PERIODIC EXPRESSION OF ENZYME ACTIVITY IN THE CELL CYCLE OF WI-38

1973 • 57 citations

High resolution analysis of the timing of replication of specific DNA sequences during S phase of mammalian cells

1983 • 56 citations

Early replication and expression of oocyte-type 5S RNA genes in a Xenopus somatic cell line carrying a translocation.

1986 • 54 citations

Studies of mammalian chromosome replication

1981 • 52 citations

Differential expression of human globin genes introduced in K562 cells.

1985 • 47 citations

THE GENETIC ANALYSIS OF MAMMALIAN CELL-CYCLE MUTANTS

1985 • 45 citations

RNA synthesis in synchronously growing populations of HeLa S3 cells. II. Rate of synthesis of individual RNA fractions

1968 • 45 citations

Origins of replication and gene regulation

1984 • 43 citations

Messenger RNA sequence complexity and homology in developmental stages of Drosophila

1981 • 41 citations

Decrease of DNA synthesis in amniotic fluid cells during the middle part of S-phase revealed by differential chromosome staining after incorporation of BrdU

1978 • 41 citations

Two phases of DNA replication in human cells

1980 • 40 citations

The time of DNA replication in the cell cycle in relation to RNA synthesis in frog embryos

1971 • 39 citations

Cell-type-specific and regulated expression of a human gamma 1 heavy-chain immunoglobulin gene in transgenic mice.

1986 • 38 citations

Chromosomal replication in Drosophila virilis

1981 • 38 citations

Replication of chromosomal DNA in diploid Drosophila melanogaster cells cultured in vitro

1977 • 36 citations

Effects of controlled exposure of L cells to bromodeoxyuridine (BUdR)

1977 • 34 citations

Reversal of DNA methylation with 5-azacytidine alters chromosome replication patterns in human lymphocyte and fibroblast cultures.

1984 • 34 citations

Replication of viral DNA sequences integrated within the chromatin of SV40-transformed chinese hamster lung cells

1981 • 31 citations

Replication variants of the human inactive X chromosome

1984 • 26 citations

The accumulation of prominent tadpole mRNAs occurs at the beginning of neurulation in Xenopus laevis embryos

1984 • 26 citations

Description of a chromosome replication unit in individual prematurely condensed human S-phase chromosomes

1984 • 24 citations

Cell-cycle dependence and properties of the HeLa cell DNA polymerase system.

1985 • 22 citations

Coordinate replication of members of the multigene family of core and H1 human histone genes.

1984 • 22 citations

ASYNCHRONOUS REPLICATION OF DNA IN A HETEROCHROMATIC SET OF CHROMOSOMES IN PSEUDOCOCCUS OBSCURUS

1965 • 21 citations

Post-transcriptional control of messenger RNA diversity in frog embryos

1979 • 19 citations

Correlation between tumorigenicity and banding pattern of chromosome 15 in murine T-cell leukemia cells and hybrids of normal and malignant cells

1984 • 15 citations

X-Ray Inhibition of DNA Synthesis at Discrete Times during S Phase in Synchronous Human Diploid Fibroblasts

1982 • 13 citations

Dna Synthesis Rate Changes During the S Phase In Mouse Epidermis

1985 • 11 citations

Temporal replication of an interspersed repeated sequence of mouse DNA

1984 • 9 citations

DNA and histone synthesis rate change during the S-period in Ehrlich ascites tumor cells

1981 • 8 citations

Analysis of a Chinese hamster temperature-sensitive cell cycle mutant arrested in early S phase

1984 • 8 citations

Uninterrupted DNA synthesis during S-phase in untransformed diploid hamster fibroblasts

1985 • 7 citations

Cell-specific variation of X chromosome replication in the Syrian hamster (Mesocricetus auratus)

1981 • 5 citations

Complexity transmission during replication

1979 • 4 citations

Cytoplasmic alteration of an established pattern of Rana pipiens chromosomal DNA replication

1974 • 2 citations