Multiple sclerosis: from basic immunopathology to immune intervention

Axonal Transection in the Lesions of Multiple Sclerosis

1998 • 4,007 citations

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

A randomized trial of plasma exchange in acute central nervous system inflammatory demyelinating disease

1999 • 878 citations

Matrix metalloproteinases: structures, evolution, and diversification

1998 • 759 citations

Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy

2001 • 630 citations

Neurological disability correlates with spinal cord axonal loss and reducedN-acetyl aspartate in chronic multiple sclerosis patients

2000 • 559 citations

Matrix metalloproteinases in immunity.

1996 • 554 citations

Imaging axonal damage of normal-appearing white matter in multiple sclerosis

1998 • 483 citations

Antigen-driven bystander suppression after oral administration of antigens.

1991 • 438 citations

Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.

1994 • 338 citations

Oligodendrocyte Apoptosis and Primary Demyelination Induced by Local TNF/p55TNF Receptor Signaling in the Central Nervous System of Transgenic Mice

1998 • 317 citations

Interferon beta‐1b inhibits gelatinase secretion and in vitro migration of human T cells: A possible mechanism for treatment efficacy in multiple sclerosis

1996 • 302 citations

Matrix metalloproteinases degrade myelin basic protein

1995 • 291 citations

Matrix Metalloproteinases in the Normal Human Central Nervous System, Microglial Nodules, and Multiple Sclerosis Lesions

1996 • 290 citations

TIMP-2 reduces proteolytic opening of blood-brain barrier by type IV collagenase

1992 • 282 citations

The Expression of Tissue-type Plasminogen Activator, Matrix Metalloproteases and Endogenous Inhibitors in the Central Nervous System in Multiple Sclerosis

1996 • 247 citations

Serum MMP-9 and TIMP-1 levels are related to MRI activity in relapsing multiple sclerosis

1999 • 232 citations

Treatment of multiple sclerosis with Copolymer-1 (Copaxone®): implicating mechanisms of Th1 to Th2/Th3 immune-deviation

1998 • 226 citations

New prospects for human stem-cell therapy in the nervous system

1999 • 219 citations

Cytokine-regulated proteases in autoimmune diseases

1994 • 214 citations

Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-α inhibitor

1997 • 205 citations

Cytokine and chemokine regulation of proMMP-9 and TIMP-1 production by human peripheral blood lymphocytes.

1997 • 205 citations

Serum gelatinase B, TIMP-1 and TIMP-2 levels in multiple sclerosis

1999 • 199 citations

Gelatinase B is present in the cerebrospinal fluid during experimental autoimmune encephalomyelitis and cleaves myelin basic protein

1993 • 192 citations

Matrix metalloproteinase-9 and -7 are regulated in experimental autoimmune encephalomyelitis

1998 • 166 citations

Matrix metalloproteinases and TIMPs: properties and implications for the rheumatic diseases

1998 • 158 citations

Suppression of experimental allergic encephalomyelitis in the Lewis rat by the matrix metalloproteinase inhibitor Ro31-9790

1995 • 146 citations

Matrix metalloproteinases and their tissue inhibitors as markers of disease subtype and response to interferon‐β therapy in relapsing and secondary‐progressive multiple sclerosis patients

2001 • 125 citations

Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors

1998 • 124 citations

Defective T cell Fas function in patients with multiple sclerosis

2000 • 110 citations

Expression of matrix metalloproteinase-9 and its inhibitors in mononuclear blood cells of patients with multiple sclerosis

1999 • 95 citations

Interferon-? secretion by peripheral blood T-cell subsets in multiple sclerosis: Correlation with disease phase and interferon-? therapy

1999 • 95 citations

Overexpression of the apoptosis inhibitor FLIP in T cells correlates with disease activity in multiple sclerosis

2001 • 76 citations

Apoptotic and effector pathways in autoimmunity

1999 • 65 citations

Metalloproteinases and their Tissue Inhibitors in Multiple Sclerosis

1999 • 63 citations

Corticosteroids protect oligodendrocytes from cytokine-induced cell death

2000 • 46 citations

Antibody-mediated Remyelination: Relevance to Multiple Sclerosis

2000 • 18 citations

Brain Disease: Therapeutic Strategies and Repair

2001 • 15 citations

Is the Routine Use of Intravenous Immunoglobulin Treatment in Neurologic Disorders Justified?

1999 • 4 citations