Metalloproteinases and their Tissue Inhibitors in Multiple Sclerosis

Rating neurologic impairment in multiple sclerosis

1983 • 14,011 citations

New diagnostic criteria for multiple sclerosis: Guidelines for research protocols

1983 • 7,404 citations

The matrix‐degrading metalloproteinases

1992 • 1,383 citations

Processing of tumour necrosis factor-α precursor by metalloproteinases

1994 • 1,200 citations

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

1989 • 1,122 citations

Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2.

1989 • 594 citations

BREAKDOWN OF THE BLOOD-BRAIN BARRIER PRECEDES SYMPTOMS AND OTHER MRI SIGNS OF NEW LESIONS IN MULTIPLE SCLEROSIS

1990 • 571 citations

T cell gelatinases mediate basement membrane transmigration in vitro.

1995 • 507 citations

Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues.

1990 • 428 citations

Interferon β‐1b decreases the migration of T lymphocytes in vitro: Effects on matrix metalloproteinase‐9

1996 • 363 citations

Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.

1994 • 338 citations

Interferon beta‐1b inhibits gelatinase secretion and in vitro migration of human T cells: A possible mechanism for treatment efficacy in multiple sclerosis

1996 • 302 citations

Matrix metalloproteinases degrade myelin basic protein

1995 • 291 citations

Matrix Metalloproteinases in the Normal Human Central Nervous System, Microglial Nodules, and Multiple Sclerosis Lesions

1996 • 290 citations

Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders

1992 • 286 citations

Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview

1997 • 281 citations

Effect of steroids on CSF matrix metalloproteinases in multiple sclerosis

1996 • 278 citations

Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in the mouse central nervous system in normal and inflammatory states.

1998 • 262 citations

The Expression of Tissue-type Plasminogen Activator, Matrix Metalloproteases and Endogenous Inhibitors in the Central Nervous System in Multiple Sclerosis

1996 • 247 citations

The complete primary structure of human matrix metalloproteinase-3. Identity with stromelysin.

1988 • 227 citations

Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-α inhibitor

1997 • 205 citations

Purification and Characterization of Two Related but Distinct Metalloproteinase Inhibitors Secreted by Bovine Aortic Endothelial Cells

1989 • 193 citations

The matrix metalloproteinases and their natural inhibitors: prospects for treating degenerative tissue diseases

1992 • 190 citations

Leukocyte Gelatinase B Cleavage Releases Encephalitogens from Human Myelin Basic Protein

1993 • 181 citations

Activation of the 92-kDa Gelatinase by Stromelysin and 4-Aminophenylmercuric Acetate

1995 • 166 citations

Suppression of experimental allergic encephalomyelitis in the Lewis rat by the matrix metalloproteinase inhibitor Ro31-9790

1995 • 146 citations

Organ‐specific autoantigens induce interferon‐γ and interleukin‐4 mRNA expression in mononuclear cells in multiple sclerosis and myasthenia gravis

1994 • 77 citations

Metastasis Suppressor Genes

1990 • 75 citations

MS: a localized immune disease of the central nervous system

1989 • 72 citations

Characterization of a human corneal metalloproteinase inhibitor (TIMP-1)

1993 • 32 citations

Metastasis suppressor genes.

1991 • 13 citations