Mucosa-Specific Targets for Regulation of IFN-γ Expression: Lamina Propria T Cells Use Differentcis-Elements than Peripheral Blood T Cells to Regulate Transactivation of IFN-γ Expression

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

1986 • 1,591 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.

1989 • 662 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression

1987 • 522 citations

Structure of the human immune interferon gene

1982 • 510 citations

Interaction of NF-κB and NFAT with the Interferon-γ Promoter

1997 • 427 citations

Role of interferon-gamma in immune cell regulation.

1995 • 374 citations

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression.

1987 • 354 citations

Stabilization of Interleukin-2 mRNA by the c-Jun NH ₂ -Terminal Kinase Pathway

1998 • 353 citations

Monoclonal antibodies identifying a novel T-Cell antigen and Ia antigens of human lymphocytes

1980 • 326 citations

Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

1992 • 322 citations

Role of interferon-γ in immune cell regulation

1995 • 295 citations

Mechanisms of IFN-gamma induction by natural killer cell stimulatory factor (NKSF/IL-12). Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2.

1992 • 284 citations

Cellular and molecular mechanisms for reduced interleukin 4 and interferon-gamma production by neonatal T cells.

1991 • 261 citations

Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells.

1993 • 203 citations

Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene.

1994 • 203 citations

The Proximal Regulatory Element of the Interferon-γ Promoter Mediates Selective Expression in T Cells

1996 • 200 citations

Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway.

1995 • 182 citations

Enzyme amplification — A general method applied to provide an immunoassisted assay for placental alkaline phosphatase

1985 • 178 citations

The Nuclear Factor YY1 Suppresses the Human Gamma Interferon Promoter through Two Mechanisms: Inhibition of AP1 Binding and Activation of a Silencer Element

1996 • 171 citations

Negative Transcriptional Regulation of the Interferon-γ Promoter by Glucocorticoids and Dominant Negative Mutants of c-Jun

1995 • 130 citations

Regulation of T-cell lymphokine gene transcription by the accessory molecule CD28.

1992 • 115 citations

Hypomethylation of the interferon‐γ gene correlates with its expression by primary T‐lineage cells

1995 • 113 citations

Transcriptional Regulation of the Interleukin-2 Gene in Normal Human Peripheral Blood T Cells

1996 • 108 citations

Differential responsiveness to CD3‐Ti vs. CD2‐dependent activation of human intestinal T lymphocytes

1990 • 97 citations

Differential Transcription Directed by Discrete Gamma Interferon Promoter Elements in Naive and Memory (Effector) CD4 T Cells and CD8 T Cells

1997 • 92 citations

Regulation of Interleukin 2 Gene Expression by CD28 Costimulation in Mouse T-Cell Clones: both Nuclear and Cytoplasmic RNAs Are Regulated with Complex Kinetics

1995 • 92 citations

Vitamin A down-regulation of IFN-gamma synthesis in cloned mouse Th1 lymphocytes depends on the CD28 costimulatory pathway.

1996 • 90 citations

DNA sequences that mediate attenuation of transcription from the mouse protooncogene myc.

1989 • 87 citations

IL-7 differentially modulates the expression of IFN-gamma and IL-4 in activated human T lymphocytes by transcriptional and post-transcriptional mechanisms.

1996 • 72 citations

Characterization of a silencer regulatory element in the human interferon-gamma promoter.

1994 • 62 citations

Retinoic Acid-induced Transcriptional Modulation of the Human Interferon-γ Promoter

1996 • 58 citations

Reduced interferon-gamma (IFN-γ) secretion with increased IFN-γ mRNA expression in atopic dermatitis: evidence for a post-transcriptional defect

1994 • 56 citations

Human mucosal cytotoxic effector cells

1987 • 48 citations

Gamma-interferon: an immunoregulatory lymphokine with immunotherapeutic potential.

1990 • 40 citations

Inflammatory bowel disease mucosal biopsies have specialized lymphokine mRNA profiles

1996 • 38 citations

Hypoproliferative human lamina propria T cells retain the capacity to secrete lymphokines when stimulated via CD2/CD28 pathways.

1996 • 37 citations

Constitutive and inducible protein/DNA interactions of the interferon-γ promoter inin vivo CD45RA and CD45RO T helper subsets

1997 • 31 citations

Post-transcriptional Regulation of Human Interleukin-2 Gene Expression at Processing of Precursor Transcripts

1995 • 29 citations

Expression of human IFN-gamma genomic DNA in transgenic mice.

1989 • 28 citations

Activation of the CD2 Pathway in Lamina Propria T Cells Up-Regulates Functionally Active AP-1 Binding to the IL-2 Promoter, Resulting in Messenger RNA Transcription and IL-2 Secretion

1998 • 24 citations

Regulation of interferon‐γ mRNA in a cytolytic T cell clone: Ca²⁺‐induced transcription followed by mRNA stabilization through activation of protein kinase C or increase in cAMP

1995 • 21 citations

Inflammatory Bowel Disease Mucosal Biopsies Have Specialized Lymphokine mRNA Profiles

1996 • 21 citations

CD28 Costimulation Augments IL-2 Secretion of Activated Lamina Propria T Cells by Increasing mRNA Stability Without Enhancing IL-2 Gene Transactivation

1999 • 12 citations

Primary Structural Repeats in Human and in Murine γ-Interferon

1986 • 7 citations