The Proximal Regulatory Element of the Interferon-γ Promoter Mediates Selective Expression in T Cells

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

Principles and Practice of Infectious Diseases.

1985 • 1,572 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

Nuclear protein CBP is a coactivator for the transcription factor CREB

1994 • 1,447 citations

Gene Splicing by Overlap Extension: Tailor-Made Genes Using the Polymerase Chain Reaction

2013 • 1,306 citations

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

1991 • 1,300 citations

The essentials of DNA methylation

1992 • 960 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines.

1991 • 835 citations

Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA

1988 • 772 citations

Leucine Repeats and an Adjacent DNA Binding Domain Mediate the Formation of Functional cFos-cJun Heterodimers

1989 • 676 citations

Parallel Association of Fos and Jun Leucine Zippers Juxtaposes DNA Binding Domains

1989 • 607 citations

NF-AT components define a family of transcription factors targeted in T-cell activation

1994 • 573 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

1990 • 517 citations

Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA

1992 • 502 citations

Nuclear factor of activated T cells contains Fos and Jun

1992 • 495 citations

Helper T‐Cell Subsets: Phenotype, Function and the Role of Lymphokines in Regulating their Development

1991 • 423 citations

Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein.

1993 • 380 citations

Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.

1991 • 364 citations

Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.

1993 • 344 citations

NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs.

1993 • 293 citations

Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor.

1990 • 292 citations

A sensitive method for the detection of beta-galactosidase in transfected mammalian cells.

1991 • 283 citations

Regulation of tumor necrosis factor/cachectin and IL-1 secretion in human mononuclear phagocytes.

1988 • 278 citations

Cellular and molecular mechanisms for reduced interleukin 4 and interferon-gamma production by neonatal T cells.

1991 • 261 citations

Novel NFAT Sites That Mediate Activation of the Interleukin-2 Promoter in Response to T-Cell Receptor Stimulation

1995 • 259 citations

Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene

1995 • 258 citations

Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc.

1993 • 245 citations

Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly.

1990 • 245 citations

mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic AMP, but not to the 12-O-tetradecanoylphorbol-13-acetate, response element.

1990 • 237 citations

The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A.

1991 • 224 citations

cAMP inhibits induction of interleukin 2 but not of interleukin 4 in T cells.

1990 • 218 citations

The NFAT-1 DNA Binding Complex in Activated T Cells Contains Fra-1 and JunB

1993 • 215 citations

A dominant repressor of cyclic adenosine 3',5'-monophosphate (cAMP)-regulated enhancer-binding protein activity inhibits the cAMP-mediated induction of the somatostatin promoter in vivo.

1992 • 208 citations

Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells.

1993 • 203 citations

Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene.

1994 • 203 citations

Prostaglandin E2 at priming of naive CD4+ T cells inhibits acquisition of ability to produce IFN-gamma and IL-2, but not IL-4 and IL-5.

1995 • 203 citations

Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter

1993 • 191 citations

Differential modulation of T helper type 1 (Th1) and T helper type 2 (Th2) cytokine secretion by prostaglandin E₂ critically depends on interleukin‐2

1995 • 181 citations

Transcriptional regulation by Fos and Jun in vitro: interaction among multiple activator and regulatory domains.

1991 • 175 citations

A common factor regulates both Th1- and Th2-specific cytokine gene expression.

1994 • 151 citations

Selective DNA bending by a variety of bZIP proteins.

1993 • 148 citations

Activation of Early Gene Expression in T Lymphocytes by Oct-1 and an Inducible Protein, OAP ⁴⁰

1991 • 144 citations

Different binding specificities and transactivation of variant CRE's by CREB complexes

1994 • 144 citations

Restricted production of interleukin 4 by activated human T cells.

1988 • 141 citations

Negative Transcriptional Regulation of the Interferon-γ Promoter by Glucocorticoids and Dominant Negative Mutants of c-Jun

1995 • 130 citations

Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signaling pathway in activated T lymphocytes.

1993 • 129 citations

Hypomethylation of the interferon‐γ gene correlates with its expression by primary T‐lineage cells

1995 • 113 citations

Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases.

1992 • 106 citations

Regulation of cytokine gene expression in T helper cell subsets.

1994 • 102 citations

Analysis of CpG methylation and genomic footprinting at the tyrosine aminotransferase gene: DNA methylation alone is not sufficient to prevent protein binding in vivo.

1991 • 95 citations

Octamer factors exert a dual effect on the IL-2 and IL-4 promoters.

1994 • 90 citations

Cyclic AMP inhibits expression of the IL-2 gene through the nuclear factor of activated T cells (NF-AT) site, and transfection of NF-AT cDNAs abrogates the sensitivity of EL-4 cells to cyclic AMP.

1995 • 84 citations

Interferon-gamma gene expression in human B-cell lines: induction by interleukin-2, protein kinase C activators, and possible effect of hypomethylation on gene regulation

1992 • 63 citations

Goals for signal transduction pathways: linking up with transcriptional regulation.

1994 • 60 citations

Functionally distinct isoforms of the CRE-BP DNA-binding protein mediate activity of a T-cell-specific enhancer.

1992 • 53 citations

Positive and negative regulation of the composite octamer motif of the interleukin 2 enhancer by AP-1, Oct-2, and retinoic acid receptor.

1994 • 42 citations

Transcription of HLA Class II Genes in the Absence of B-Cell-Specific Octamer-Binding Factor

1988 • 33 citations

Isolation and characterization of nuclear proteins that bind to T cell receptor V beta decamer motif.

1992 • 31 citations

Regulation of cAMP-responsive enhancer binding proteins during cell cycle progression in T lymphocytes stimulated by IL-2.

1995 • 28 citations

Human B cell lines express the interferon gamma gene

1992 • 19 citations